Search Results - "Slavik, Kailey"

CBASS to cGAS-STING: The Origins and Mechanisms of Nucleotide Second Messenger Immune Signaling by Slavik, Kailey M, Kranzusch, Philip J

“…Host defense against viral pathogens is an essential function for all living organisms. In cell-intrinsic innate immunity, dedicated sensor proteins recognize…”
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cGLRs are a diverse family of pattern recognition receptors in innate immunity by Li, Yao, Slavik, Kailey M., Toyoda, Hunter C., Morehouse, Benjamin R., de Oliveira Mann, Carina C., Elek, Anamaria, Levy, Shani, Wang, Zhenwei, Mears, Kepler S., Liu, Jingjing, Kashin, Dmitry, Guo, Ximing, Mass, Tali, Sebé-Pedrós, Arnau, Schwede, Frank, Kranzusch, Philip J.

“…Cyclic GMP-AMP synthase (cGAS) is an enzyme in human cells that controls an immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide…”
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The virus-induced cyclic dinucleotide 2'3'-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila by Cai, Hua, Li, Lihua, Slavik, Kailey M, Huang, Jingxian, Yin, Ting, Ai, Xianlong, Hédelin, Léna, Haas, Gabrielle, Xiang, Zhangmin, Yang, Yunyun, Li, Xiaoyan, Chen, Yuqiang, Wei, Ziming, Deng, Huimin, Chen, Di, Jiao, Renjie, Martins, Nelson, Meignin, Carine, Kranzusch, Philip J, Imler, Jean-Luc

“…In mammals, the enzyme cGAS senses the presence of cytosolic DNA and synthesizes the cyclic dinucleotide (CDN) 2'3'-cGAMP, which triggers STING-dependent…”
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Birth-and-Death Evolution of the Fatty Acyl-CoA Reductase (FAR) Gene Family and Diversification of Cuticular Hydrocarbon Synthesis in Drosophila by Finet, Cédric, Slavik, Kailey, Pu, Jian, Carroll, Sean B, Chung, Henry

“…The birth-and-death evolutionary model proposes that some members of a multigene family are phylogenetically stable and persist as a single copy over time,…”
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Multifunctional Protein A Is the Only Viral Protein Required for Nodavirus RNA Replication Crown Formation by den Boon, Johan A, Zhan, Hong, Unchwaniwala, Nuruddin, Horswill, Mark, Slavik, Kailey, Pennington, Janice, Navine, Amanda, Ahlquist, Paul

“…Positive-strand RNA virus RNA genome replication occurs in membrane-associated RNA replication complexes (RCs). Nodavirus RCs are outer mitochondrial membrane…”
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cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila by Slavik, Kailey M, Morehouse, Benjamin R, Ragucci, Adelyn E, Zhou, Wen, Ai, Xianlong, Chen, Yuqiang, Li, Lihua, Wei, Ziming, Bähre, Heike, König, Martin, Seifert, Roland, Lee, Amy S Y, Cai, Hua, Imler, Jean-Luc, Kranzusch, Philip J

“…Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that produces the second messenger cG[2'-5']pA[3'-5']p (2'3'-cGAMP) and controls activation of innate…”
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Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases by Mosallanejad, Kenta, Kennedy, Stephanie N, Bahleda, Kristin M, Slavik, Kailey M, Zhou, Wen, Govande, Apurva A, Hancks, Dustin C, Kranzusch, Philip J, Kagan, Jonathan C

“…The mechanisms by which innate immune receptors mediate self-nonself discrimination are unclear. In this study, we found species-specific molecular…”
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cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila by Slavik, Kailey M., Morehouse, Benjamin R., Ragucci, Adelyn E., Zhou, Wen, Ai, Xianlong, Chen, Yuqiang, Li, Lihua, Wei, Ziming, Bähre, Heike, König, Martin, Seifert, Roland, Lee, Amy S. Y., Cai, Hua, Imler, Jean-Luc, Kranzusch, Philip J.

“…Cyclic GMP–AMP synthase (cGAS) is a cytosolic DNA sensor that produces the second messenger cG[2′–5′]pA[3′–5′]p (2′3′-cGAMP) and controls activation of innate…”
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The virus-induced cyclic dinucleotide 2′3′-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila by Cai, Hua, Li, Lihua, Slavik, Kailey M., Huang, Jingxian, Yin, Ting, Ai, Xianlong, Hédelin, Léna, Haas, Gabrielle, Xiang, Zhangmin, Yang, Yunyun, Li, Xiaoyan, Chen, Yuqiang, Wei, Ziming, Deng, Huimin, Chen, Di, Jiao, Renjie, Martins, Nelson, Meignin, Carine, Kranzusch, Philip J., Imler, Jean-Luc

“…In mammals, the enzyme cGAS senses the presence of cytosolic DNA and synthesizes the cyclic dinucleotide (CDN) 2′3′-cGAMP, which triggers STING-dependent…”
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cGas-Like Receptors in Animal Innate Immunity by Slavik, Kailey Madison

“…The molecular detection of pathogen infection and subsequent initiation of an immune response is an essential function of cellular life. Animals encode innate…”
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