Search Results - "Slatter, David A"

Proline provides site-specific flexibility for in vivo collagen by Chow, Wing Ying, Forman, Chris J., Bihan, Dominique, Puszkarska, Anna M., Rajan, Rakesh, Reid, David G., Slatter, David A., Colwell, Lucy J., Wales, David J., Farndale, Richard W., Duer, Melinda J.

“…Fibrillar collagens have mechanical and biological roles, providing tissues with both tensile strength and cell binding sites which allow molecular…”
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NMR Spectroscopy of Native and in Vitro Tissues Implicates PolyADP Ribose in Biomineralization by Chow, W. Ying, Rajan, Rakesh, Muller, Karin H., Reid, David G., Skepper, Jeremy N., Wong, Wai Ching, Brooks, Roger A., Green, Maggie, Bihan, Dominique, Farndale, Richard W., Slatter, David A., Shanahan, Catherine M., Duer, Melinda J.

“…Nuclear magnetic resonance (NMR) spectroscopy is useful to determine molecular structure in tissues grown in vitro only if their fidelity, relative to native…”
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Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity by Allen-Redpath, Keith, Aldrovandi, Maceler, Lauder, Sarah N., Gketsopoulou, Anastasia, Tyrrell, Victoria J., Slatter, David A., Andrews, Robert, Watkins, W. John, Atkinson, Georgia, McNeill, Eileen, Gilfedder, Anna, Protty, Majd, Burston, James, Johnson, Sam R. C., Rodrigues, Patricia R. S., Jones, Dylan O., Lee, Regent, Handa, Ashok, Channon, Keith, Obaji, Samya, Alvarez-Jarreta, Jorge, Krönke, Gerhard, Ackermann, Jochen, Jenkins, P. Vince, Collins, Peter W., O’Donnell, Valerie B.

“…Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease with high mortality and limited treatment options. How blood lipids regulate AAA…”
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Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis by Lauder, Sarah N, Allen-Redpath, Keith, Slatter, David A, Aldrovandi, Maceler, O'Connor, Anne, Farewell, Daniel, Percy, Charles L, Molhoek, Jessica E, Rannikko, Sirpa, Tyrrell, Victoria J, Ferla, Salvatore, Milne, Ginger L, Poole, Alastair W, Thomas, Christopher P, Obaji, Samya, Taylor, Philip R, Jones, Simon A, de Groot, Phillip G, Urbanus, Rolf T, Hörkkö, Sohvi, Uderhardt, Stefan, Ackermann, Jochen, Vince Jenkins, P, Brancale, Andrea, Krönke, Gerhard, Collins, Peter W, O'Donnell, Valerie B

“…Blood coagulation functions as part of the innate immune system by preventing bacterial invasion, and it is critical to stopping blood loss (hemostasis)…”
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The procoagulant activity of tissue factor expressed on fibroblasts is increased by tissue factor-negative extracellular vesicles by Rosas, Marcela, Slatter, David A, Obaji, Samya G, Webber, Jason P, Alvarez-Jarreta, Jorge, Thomas, Christopher P, Aldrovandi, Maceler, Tyrrell, Victoria J, Jenkins, Peter V, O'Donnell, Valerie B, Collins, Peter W

“…Tissue factor (TF) is critical for the activation of blood coagulation. TF function is regulated by the amount of externalised phosphatidylserine (PS) and…”
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Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation[S] by Aldrovandi, Maceler, Hammond, Victoria J., Podmore, Helen, Hornshaw, Martin, Clark, Stephen R., Marnett, Lawrence J., Slatter, David A., Murphy, Robert C., Collins, Peter W., O'Donnell, Valerie B.

“…Oxidized phospholipids (oxPLs) generated nonenzymatically display pleiotropic biological actions in inflammation. Their generation by cellular cyclooxygenases…”
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Hydroxyproline Ring Pucker Causes Frustration of Helix Parameters in the Collagen Triple Helix by Ying Chow, W., Bihan, Dominique, Forman, Chris J., Slatter, David A., Reid, David G., Wales, David J., Farndale, Richard W., Duer, Melinda J.

“…Collagens, the most abundant proteins in mammals, are defined by their triple-helical structures and distinctive Gly-Xaa-Yaa repeating sequence, where Xaa is…”
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Identification and structural analysis of type I collagen sites in complex with fibronectin fragments by Erat, Michèle C, Slatter, David A, Lowe, Edward D, Millard, Christopher J, Farndale, Richard W, Campbell, Iain D, Vakonakis, Ioannis

“…Collagen and fibronectin are major components of vertebrate extracellular matrices. Their association and distribution control the development and properties…”
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LipidFinder: A computational workflow for discovery of lipids identifies eicosanoid-phosphoinositides in platelets by O'Connor, Anne, Brasher, Christopher J, Slatter, David A, Meckelmann, Sven W, Hawksworth, Jade I, Allen, Stuart M, O'Donnell, Valerie B

“…Accurate and high-quality curation of lipidomic datasets generated from plasma, cells, or tissues is becoming essential for cell biology investigations and…”
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Integrin Activation State Determines Selectivity for Novel Recognition Sites in Fibrillar Collagens by Siljander, Pia R-M, Hamaia, Samir, Peachey, Anthony R, Slatter, David A, Smethurst, Peter A, Ouwehand, Willem H, Knight, C Graham, Farndale, Richard W

“…Only three recognition motifs, GFOGER, GLOGER, and GASGER, all present in type I collagen, have been identified to date for collagen-binding integrins, such as…”
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Mapping the Human Platelet Lipidome Reveals Cytosolic Phospholipase A2 as a Regulator of Mitochondrial Bioenergetics during Activation by Slatter, David A., Aldrovandi, Maceler, O’Connor, Anne, Allen, Stuart M., Brasher, Christopher J., Murphy, Robert C., Mecklemann, Sven, Ravi, Saranya, Darley-Usmar, Victor, O’Donnell, Valerie B.

“…Human platelets acutely increase mitochondrial energy generation following stimulation. Herein, a lipidomic circuit was uncovered whereby the substrates for…”
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DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression by Aldrovandi, Maceler, Hinz, Christine, Lauder, Sarah N., Podmore, Helen, Hornshaw, Martin, Slatter, David A., Tyrrell, Victoria J., Clark, Stephen R., Marnett, Lawrence J., Collins, Peter W., Murphy, Robert C., O’Donnell, Valerie B.

“…Activated platelets generate an eicosanoid proposed to be 8-hydroxy-9,10-dioxolane A3 (DXA3). Herein, we demonstrate that significant amounts of DXA3 are…”
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Identification of a New Cross-link and Unique Histidine Adduct from Bovine Serum Albumin Incubated with Malondialdehyde by Slatter, David A., Avery, Nicholas C., Bailey, Allen J.

“…Malondialdehyde, acetaldehyde, acrolein, and 4-hydroxynonenal are all products of fatty acid oxidation found in the fatty streaks of atherosclerotic arteries…”
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OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice by Barrow, Alexander David, Raynal, Nicolas, Andersen, Thomas Levin, Slatter, David A, Bihan, Dominique, Pugh, Nicholas, Cella, Marina, Kim, Taesoo, Rho, Jaerang, Negishi-Koga, Takako, Delaisse, Jean-Marie, Takayanagi, Hiroshi, Lorenzo, Joseph, Colonna, Marco, Farndale, Richard W, Choi, Yongwon, Trowsdale, John

“…Osteoclasts are terminally differentiated leukocytes that erode the mineralized bone matrix. Osteoclastogenesis requires costimulatory receptor signaling…”
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The recognition of collagen and triple-helical toolkit peptides by MMP-13: sequence specificity for binding and cleavage by Howes, Joanna-Marie, Bihan, Dominique, Slatter, David A, Hamaia, Samir W, Packman, Len C, Knauper, Vera, Visse, Robert, Farndale, Richard W

“…Remodeling of collagen by matrix metalloproteinases (MMPs) is crucial to tissue homeostasis and repair. MMP-13 is a collagenase with a substrate preference for…”
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Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid by Hinz, Christine, Aldrovandi, Maceler, Uhlson, Charis, Marnett, Lawrence J., Longhurst, Hilary J., Warner, Timothy D., Alam, Saydul, Slatter, David A., Lauder, Sarah N., Allen-Redpath, Keith, Collins, Peter W., Murphy, Robert C., Thomas, Christopher P., O’Donnell, Valerie B.

“…Eicosanoids are important mediators of fever, pain, and inflammation that modulate cell signaling during acute and chronic disease. We show by using lipidomics…”
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Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies by Slatter, David A, Percy, Charles L, Allen-Redpath, Keith, Gajsiewicz, Joshua M, Brooks, Nick J, Clayton, Aled, Tyrrell, Victoria J, Rosas, Marcela, Lauder, Sarah N, Watson, Andrew, Dul, Maria, Garcia-Diaz, Yoel, Aldrovandi, Maceler, Heurich, Meike, Hall, Judith, Morrissey, James H, Lacroix-Desmazes, Sebastien, Delignat, Sandrine, Jenkins, P Vincent, Collins, Peter W, O'Donnell, Valerie B

“…Hemostatic defects are treated using coagulation factors; however, clot formation also requires a procoagulant phospholipid (PL) surface. Here, we show that…”
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The effect of purity upon the triple-helical stability of collagenous peptides by Slatter, David A, Bihan, Dominique G, Farndale, Richard W

“…Abstract Collagen is the fundamental structural protein, comprising 25–35% of the total body protein, its rod-like triple helix providing support in many…”
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Metabolic Dysregulation of the Lysophospholipid/Autotaxin Axis in the Chromosome 9p21 Gene SNP rs10757274 by Meckelmann, Sven W., Hawksworth, Jade I., White, Daniel, Andrews, Robert, Rodrigues, Patricia, O’Connor, Anne, Alvarez-Jarreta, Jorge, Tyrrell, Victoria J., Hinz, Christine, Zhou, You, Williams, Julie, Aldrovandi, Maceler, Watkins, William J., Engler, Adam J., Lo Sardo, Valentina, Slatter, David A., Allen, Stuart M., Acharya, Jay, Mitchell, Jacquie, Cooper, Jackie, Aoki, Junken, Kano, Kuniyuki, Humphries, Steve E., O’Donnell, Valerie B.

“…Common chromosome 9p21 single nucleotide polymorphisms (SNPs) increase coronary heart disease risk, independent of traditional lipid risk factors. However,…”
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Interpreting Sequences from Mastodon and T. rex by Asara, John M., Garavelli, John S., Slatter, David A., Schweitzer, Mary H., Freimark, Lisa M., Phillips, Matthew, Cantley, Lewis C.

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