Search Results - "Slatkin, Daniel N"

Gold nanoparticle imaging and radiotherapy of brain tumors in mice by Hainfeld, James F, Smilowitz, Henry M, O'Connor, Michael J, Dilmanian, Farrokh Avraham, Slatkin, Daniel N

“…To test intravenously injected gold nanoparticles for x-ray imaging and radiotherapy enhancement of large, imminently lethal, intracerebral malignant gliomas…”
Get more information

Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma by Hainfeld, James F, Dilmanian, F Avraham, Zhong, Zhong, Slatkin, Daniel N, Kalef-Ezra, John A, Smilowitz, Henry M

“…The purpose of this study is to test the hypothesis that gold nanoparticle (AuNP, nanogold)-enhanced radiation therapy (nanogold radiation therapy, NRT) is…”
Get more information

The use of gold nanoparticles to enhance radiotherapy in mice by Hainfeld, James F, Slatkin, Daniel N, Smilowitz, Henry M

“…Mice bearing subcutaneous EMT-6 mammary carcinomas received a single intravenous injection of 1.9 nm diameter gold particles (up to 2.7 g Au/kg body weight),…”
Get more information

Gold nanoparticle hyperthermia reduces radiotherapy dose by Hainfeld, James F., PhD, Lin, Lynn, BA, Slatkin, Daniel N., MD, Avraham Dilmanian, F., PhD, Vadas, Timothy M., PhD, Smilowitz, Henry M., PhD

“…Abstract Gold nanoparticles can absorb near infrared light, resulting in heating and ablation of tumors. Gold nanoparticles have also been used for enhancing…”
Get full text

Infrared-transparent gold nanoparticles converted by tumors to infrared absorbers cure tumors in mice by photothermal therapy by Hainfeld, James F, O'Connor, Michael J, Lin, Ping, Qian, Luping, Slatkin, Daniel N, Smilowitz, Henry M

“…Gold nanoparticles (AuNPs) absorb light and can be used to heat and ablate tumors. The "tissue window" at ∼ 800 nm (near infrared, NIR) is optimal for best…”
Get full text

Iodine nanoparticles enhance radiotherapy of intracerebral human glioma in mice and increase efficacy of chemotherapy by Hainfeld, James F., Ridwan, Sharif M., Stanishevskiy, Yaroslav, Panchal, Rahul, Slatkin, Daniel N., Smilowitz, Henry M.

“…Gliomas and other brain tumors have evaded durable therapies, ultimately causing about 20% of all cancer deaths. Tumors are widespread in the brain at time of…”
Get full text

Microlocalization of lipophilic porphyrins: Non-toxic enhancers of boron neutron-capture therapy by Smilowitz, Henry M., Slatkin, Daniel N., Micca, Peggy L., Miura, Michiko

“…Abstract Purpose: To compare the macroscopic and microscopic distributions of the novel non-toxic lipophilic porphyrins copper (II) 5,10,15,20-tetrakis-(3-[1,2…”
Get full text

Radiotherapy enhancement with gold nanoparticles by Hainfeld, James F., Dilmanian, F. Avraham, Slatkin, Daniel N., Smilowitz, Henry M.

“…Gold is an excellent absorber of X‐rays. If tumours could be loaded with gold, this would lead to a higher dose to the cancerous tissue compared with the dose…”
Get full text

Alban Köhler (1874-1947): Inventor of grid therapy by Laissue, Jean A, Blattmann, Hans, Slatkin, Daniel N

“…Grid (or sieve) therapy ("Gitter-" oder "Siebtherapie"), spatially fractionated kilo- and megavolt X-ray therapy, was invented in 1909 by Alban Köhler, a…”
Get full text

Response of the rat spinal cord to X-ray microbeams by Laissue, Jean A, Bartzsch, Stefan, Blattmann, Hans, Bräuer-Krisch, Elke, Bravin, Alberto, Dalléry, Dominique, Djonov, Valentin, Hanson, Albert L, Hopewell, John W, Kaser-Hotz, Barbara, Keyriläinen, Jani, Laissue, Pierre Philippe, Miura, Michiko, Serduc, Raphaël, Siegbahn, Albert E, Slatkin, Daniel N

“…Abstract Background and purpose To quantify the late dose-related responses of the rat cervical spinal cord to X-ray irradiations by an array of microbeams or…”
Get full text

Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: trial design and early clinical results by Coderre, J A, Elowitz, E H, Chadha, M, Bergland, R, Capala, J, Joel, D D, Liu, H B, Slatkin, D N, Chanana, A D

“…A Phase I/II clinical trial of boron neutron capture therapy (BNCT) for glioblastoma multiforme is underway using the amino acid analog p-boronophenylalanine…”
Get full text

Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery by Smilowitz, Henry M, Meyers, Alexandria, Rahman, Khalil, Dyment, Nathaniel A, Sasso, Dan, Xue, Crystal, Oliver, Douglas L, Lichtler, Alexander, Deng, Xiaomeng, Ridwan, Sharif M, Tarmu, Lauren J, Wu, Qian, Salner, Andrew L, Bulsara, Ketan R, Slatkin, Daniel N, Hainfeld, James F

“…Intravenously (IV)-injected gold nanoparticles (AuNPs) powerfully enhance the efficacy of X-ray therapy of tumors including advanced gliomas. However,…”
Get full text

Tetrahedral irradiation protocol for microbeam radiation therapy by Slatkin, Daniel N

“…Optimizing microbeam radiation therapy requires that the patient be repositioned between exposures. Optional movements of a patient-gantry are described that…”
Get more information

Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron‐wiggler‐generated X rays by Laissue, Jean A., Geiser, Gabrielle, Spanne, Per O., Dilmanian, F. Avraham, Gebbers, Jan‐Olaf, Geiser, Marianne, Wu, Xiao‐Ye, Makar, Michael S., Micca, Peggy L., Nawrocky, Marta M., Joel, Darrel D., Slatkin, Daniel N.

“…Adult‐rat‐brain tissues display an unusually high resistance to necrosis when serially irradiated with parallel, thin slices of a microplanar (i.e.,…”
Get full text

Boron neutron capture therapy for glioblastoma multiforme: interim results from the phase I/II dose-escalation studies by Chanana, AD, Capala, J, Chadha, M, Coderre, JA, Diaz, AZ, Elowitz, EH, Iwai, J, Joel, DD, Liu, HB, Ma, R, Pendzick, N, Peress, NS, Shady, MS, Slatkin, DN, Tyson, GW, Wielopolski, L

“…OBJECTIVE: The primary objective of these Phase I/II dose-escalation studies is to evaluate the safety of boronophenylalanine (BPA)-fructose-mediated boron…”
Get full text

Uniaxial and biaxial irradiation protocols for microbeam radiation therapy by Slatkin, Daniel N

“…Synchrotron-generated x-ray beams for microbeam radiation therapy (MRT) are fixed in space, so three-dimensional treatment planning would require that a…”
Get more information

A misprint in a description of microbeam irradiations of rats' heads by Laissue, Jean A., Blattmann, Hans, Siegbahn, Erik A., Slatkin, Daniel N.

Get full text

Boron Neutron Capture Therapy of a Murine Mammary Carcinoma Using a Lipophilic Carboranyltetraphenylporphyrin by Miura, Michiko, Morris, Gerard M., Micca, Peggy L., Lombardo, Diana T., Youngs, Kelly M., Kalef-Ezra, John A., Hoch, Duane A., Slatkin, Daniel N., Ma, Ruimei, Coderre, Jeffrey A.

“…The first control of a malignant tumor in vivo by porphyrin-mediated boron neutron capture therapy (BNCT) is described. In mice bearing implanted EMT-6 mammary…”
Get full text

Derivations of relative biological effectiveness for the high-let radiations produced during boron neutron capture irradiations of the 9L rat gliosarcoma in vitro and in vivo by Coderre, J A, Makar, M S, Micca, P L, Nawrocky, M M, Liu, H B, Joel, D D, Slatkin, D N, Amols, H I

“…Relative biological effectiveness (RBE) values for the high linear-energy-transfer particles produced during boron neutron capture therapy have generally been…”
Get more information

Synthesis of a nickel tetracarboranylphenylporphyrin for boron neutron‐capture therapy: Biodistribution and toxicity in tumor‐bearing mice by Miura, Michiko, Micca, Peggy L., Fisher, Craig D., Heinrichs, John C., Donaldson, Jason A., Finkel, Gerald C., Slatkin, Daniel N.

“…Nickel‐2,3,7,8,12,13,17,18‐octaacetic acid‐5,10,15,20‐tetra‐[3‐carboranyl‐methoxyphenyl]‐porphyrin octamethylester (NiTCP) was given in a Cremophor EL, a…”
Get full text