Search Results - "Slansky, Jill E"

Granzymes: The Molecular Executors of Immune-Mediated Cytotoxicity by Hay, Zachary L Z, Slansky, Jill E

“…Cytotoxic T lymphocytes, differentiated CD8+ T cells, use multiple mechanisms to mediate their function, including release of granules containing perforin and…”
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A review of emerging physical transfection methods for CRISPR/Cas9-mediated gene editing by Fajrial, Apresio K, He, Qing Qing, Wirusanti, Nurul I, Slansky, Jill E, Ding, Xiaoyun

“…Gene editing is a versatile technique in biomedicine that promotes fundamental research as well as clinical therapy. The development of Clustered Regularly…”
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Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes by Desch, A Nicole, Gibbings, Sophie L, Goyal, Rajni, Kolde, Raivo, Bednarek, Joe, Bruno, Tullia, Slansky, Jill E, Jacobelli, Jordan, Mason, Robert, Ito, Yoko, Messier, Elise, Randolph, Gwendalyn J, Prabagar, Miglena, Atif, Shaikh M, Segura, Elodie, Xavier, Ramnik J, Bratton, Donna L, Janssen, William J, Henson, Peter M, Jakubzick, Claudia V

“…The pulmonary mononuclear phagocyte system is a critical host defense mechanism composed of macrophages, monocytes, monocyte-derived cells, and dendritic…”
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Implications of Antigen Selection on T Cell-Based Immunotherapy by Camp, Faye, Slansky, Jill

“…Many immunotherapies rely on CD8+ effector T cells to recognize and kill cognate tumor cells. These T cell-based immunotherapies include adoptive cell therapy,…”
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HITM-SURE: Hepatic immunotherapy for metastases phase Ib anti-CEA CAR-T study utilizing pressure enabled drug delivery by Katz, Steven C, Moody, Ashley E, Guha, Prajna, Hardaway, John C, Prince, Ethan, LaPorte, Jason, Stancu, Mirela, Slansky, Jill E, Jordan, Kimberly R, Schulick, Richard D, Knight, Robert, Saied, Abdul, Armenio, Vincent, Junghans, Richard P

“…In recent years, cell therapy technologies have resulted in impressive results in hematologic malignancies. Treatment of solid tumors with chimeric antigen…”
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Peptide Centric Vβ Specific Germline Contacts Shape a Specialist T Cell Response by Wang, Yang, Tsitsiklis, Alexandra, Devoe, Stephanie, Gao, Wei, Chu, H Hamlet, Zhang, Yan, Li, Wei, Wong, Wing Ki, Deane, Charlotte M, Neau, David, Slansky, Jill E, Thomas, Paul G, Robey, Ellen A, Dai, Shaodong

“…Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified by elite control of HIV in individuals harboring HLA-B57. To…”
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MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer by Williams, Michelle M., Christenson, Jessica L., O’Neill, Kathleen I., Hafeez, Sabrina A., Ihle, Claire L., Spoelstra, Nicole S., Slansky, Jill E., Richer, Jennifer K.

“…Many immune suppressive mechanisms utilized by triple negative breast cancer (TNBC) are regulated by oncogenic epithelial-to-mesenchymal transition (EMT). How…”
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Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma by Tamburini, Beth A, Phang, Tzu L, Fosmire, Susan P, Scott, Milcah C, Trapp, Susan C, Duckett, Megan M, Robinson, Sally R, Slansky, Jill E, Sharkey, Leslie C, Cutter, Gary R, Wojcieszyn, John W, Bellgrau, Donald, Gemmill, Robert M, Hunter, Lawrence E, Modiano, Jaime F

“…The etiology of hemangiosarcoma remains incompletely understood. Its common occurrence in dogs suggests predisposing factors favor its development in this…”
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Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens by Jordan, Kimberly R, McMahan, Rachel H, Kemmler, Charles B, Kappler, John W, Slansky, Jill E

“…Peptide vaccines enhance the response of T cells toward tumor antigens and represent a strategy to augment antigen-independent immunotherapies of cancer…”
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Clinical and immune responses to neoadjuvant fulvestrant with or without enzalutamide in ER+/Her2− breast cancer by Elias, Anthony D., Staley, Alyse W., Fornier, Monica, Vidal, Gregory A., Alami, Vida, Sams, Sharon, Spoelstra, Nicole S., Goodspeed, Andrew, Kabos, Peter, Diamond, Jennifer R., Shagisultanova, Elena, Gallagher, Rosa I., Wulfkuhle, Julia D., Petricoin, Emanuel F., Zolman, Kathryn L., McSpadden, Tessa, Jordan, Kimberly R., Slansky, Jill E., Borges, Virginia F., Gao, Dexiang, Richer, Jennifer K.

“…Most ER+ breast cancers (BC) express androgen receptors (AR). This randomized phase II trial of 4 months of neoadjuvant fulvestrant (Fulv) alone or with…”
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The Goldilocks model for TCR-too much attraction might not be best for vaccine design by Slansky, Jill E, Jordan, Kimberly R

“…Recent research on T cell-antigen interactions suggests that tighter binding is not always better at eliciting an effective immune response…”
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Alternative Splicing in Tumors — A Path to Immunogenicity? by Slansky, Jill E, Spellman, Paul T

“…The ability of cancer cells to elicit an immune response depends on several factors, including their expression of neoantigens. How many antigens do tumor…”
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Peptide mimotopes alter T cell function in cancer and autoimmunity by Slansky, Jill E, Nakayama, Maki

“…T cells recognize and respond to self antigens in both cancer and autoimmunity. One strategy to influence this response is to incorporate amino acid…”
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Multiple Associations Between a Broad Spectrum of Autoimmune Diseases, Chronic Inflammatory Diseases and Cancer by FRANKS, Alexis L, SLANSKY, Jill E

“…Many recent studies suggest the immune system plays a significant role in the pathogenesis of autoimmune diseases, chronic inflammatory diseases, and cancer…”
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T‐cell receptor affinity in the age of cancer immunotherapy by Hoffmann, Michele M., Slansky, Jill E.

“…The strength of the interaction between T‐cell receptors (TCRs) and their ligands, peptide/major histocompatibility complex complexes (pMHCs), is one of the…”
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A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma by Greene, Lisa I, Bruno, Tullia C, Christenson, Jessica L, D'Alessandro, Angelo, Culp-Hill, Rachel, Torkko, Kathleen, Borges, Virginia F, Slansky, Jill E, Richer, Jennifer K

“…Tryptophan catabolism is an attractive target for reducing tumor progression and improving antitumor immunity in multiple cancers. Tumor infiltration by CD8 T…”
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Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor Immunity by Waugh, Katherine A, Leach, Sonia M, Slansky, Jill E

“…Transcription is a dynamic process influenced by the cellular environment: healthy, transformed, and otherwise. Genome-wide mRNA expression profiles reflect…”
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CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8+ T-cell responses by upregulating MHC-I expression by Westrich, Joseph A., Vermeer, Daniel W., Silva, Alexa, Bonney, Stephanie, Berger, Jennifer N., Cicchini, Louis, Greer, Robert O., Song, John I., Raben, David, Slansky, Jill E., Lee, John H., Spanos, William C., Pyeon, Dohun

“…Evasion of the host immune responses is critical for both persistent human papillomavirus (HPV) infection and associated cancer progression. We have previously…”
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Identification and Characterization of the Immunodominant Rat HER-2/neu MHC Class I Epitope Presented by Spontaneous Mammary Tumors from HER-2/neu-Transgenic Mice by Ercolini, Anne M, Machiels, Jean-Pascal H, Chen, Yi Cheng, Slansky, Jill E, Giedlen, Martin, Reilly, R. Todd, Jaffee, Elizabeth M

“…The HER-2/neu (neu-N)-transgenic mice are a clinically relevant model of breast cancer. They are derived from the parental FVB/N mouse strain and are…”
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Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer by Wei, Pengcheng, Jordan, Kimberly R., Buhrman, Jonathan D., Lei, Jun, Deng, Hexiang, Marrack, Philippa, Dai, Shaodong, Kappler, John W., Slansky, Jill E., Yin, Lei

“…Tumors frequently express unmutated self-tumor–associated antigens (self-TAAs). However, trial results using self-TAAs as vaccine targets against cancer are…”
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