Search Results - "Slagboom, PEline"

Persistent epigenetic differences associated with prenatal exposure to famine in humans by Heijmans, Bastiaan T, Tobi, Elmar W, Stein, Aryeh D, Putter, Hein, Blauw, Gerard J, Susser, Ezra S, Slagboom, P. Eline, Lumey, L.H

“…Extensive epidemiologic studies have suggested that adult disease risk is associated with adverse environmental conditions early in development. Although the…”
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DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific by Tobi, Elmar W., Lumey, L.H., Talens, Rudolf P., Kremer, Dennis, Putter, Hein, Stein, Aryeh D., Slagboom, P. Eline, Heijmans, Bastiaan T.

“…Prenatal famine in humans has been associated with various later-life consequences, depending on the gestational timing of the insult and the sex of the…”
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The continuing value of twin studies in the omics era by van Dongen, Jenny, Slagboom, P. Eline, Draisma, Harmen H. M., Martin, Nicholas G., Boomsma, Dorret I.

“…Key Points Twins are valuable subjects for studies in which control over genetic background and early environmental influences is desired. Monozygotic twins…”
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Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology by Talens, Rudolf P., Boomsma, Dorret I., Tobi, Elmar W., Kremer, Dennis, Jukema, J. Wouter, Willemsen, Gonneke, Putter, Hein, Slagboom, P. Eline, Heijmans, Bastiaan T.

“…ABSTRACTThe prospect of finding epigenetic risk factors for complex diseases would be greatly enhanced if DNA from existing biobanks, which is generally…”
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Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health by Reiding, Karli R., Ruhaak, L. Renee, Uh, Hae-Won, el Bouhaddani, Said, van den Akker, Erik B., Plomp, Rosina, McDonnell, Liam A., Houwing-Duistermaat, Jeanine J., Slagboom, P. Eline, Beekman, Marian, Wuhrer, Manfred

“…Glycosylation is an abundant co- and post-translational protein modification of importance to protein processing and activity. Although not template-defined,…”
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Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited by Deelen, Joris, Beekman, Marian, Uh, Hae‐Won, Helmer, Quinta, Kuningas, Maris, Christiansen, Lene, Kremer, Dennis, van der Breggen, Ruud, Suchiman, H. Eka D., Lakenberg, Nico, van den Akker, Erik B., Passtoors, Willemijn M., Tiemeier, Henning, van Heemst, Diana, de Craen, Anton J., Rivadeneira, Fernando, de Geus, Eco J, Perola, Markus, van der Ouderaa, Frans J., Gunn, David A., Boomsma, Dorret I., Uitterlinden, André G., Christensen, Kaare, van Duijn, Cornelia M., Heijmans, Bastiaan T., Houwing‐Duistermaat, Jeanine J., Westendorp, Rudi G. J., Slagboom, P. Eline

“…Summary By studying the loci that contribute to human longevity, we aim to identify mechanisms that contribute to healthy aging. To identify such loci, we…”
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Associations between age and gray matter volume in anatomical brain networks in middle‐aged to older adults by Hafkemeijer, Anne, Altmann‐Schneider, Irmhild, Craen, Anton J. M., Slagboom, P. Eline, Grond, Jeroen, Rombouts, Serge A. R. B.

“…Summary Aging is associated with cognitive decline, diminished brain function, regional brain atrophy, and disrupted structural and functional brain…”
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Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study by Westendorp, Rudi G.J., Van Heemst, Diana, Rozing, Maarten P., Frölich, Marijke, Mooijaart, Simon P., Blauw, Gerard-Jan, Beekman, Marian, Heijmans, Bastiaan T., De Craen, Anton J.M., Slagboom, P. Eline

“…OBJECTIVES: To compare the risk of mortality of nonagenarian siblings with that of sporadic nonagenarians (not selected on having a nonagenarian sibling) and…”
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Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus by Heijmans, Bastiaan T., Kremer, Dennis, Tobi, Elmar W., Boomsma, Dorret I., Slagboom, P. Eline

“…Epigenetic variation may significantly contribute to the risk of common disease. Currently, little is known about the extent and causes of epigenetic…”
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Hallmark features of immunosenescence are absent in familial longevity by Derhovanessian, Evelyna, Maier, Andrea B, Beck, Robert, Jahn, Gerhard, Hähnel, Karin, Slagboom, P Eline, de Craen, Anton J M, Westendorp, Rudi G J, Pawelec, Graham

“…Seropositivity for CMV is one of the parameters of the "immune risk profile" associated with mortality in longitudinal studies of the very elderly and may…”
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Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity by Beekman, Marian, Nederstigt, Christa, Suchiman, H. Eka D., Kremer, Dennis, van der Breggen, Ruud, Lakenberg, Nico, Alemayehu, Wendimagegn Ghidey, de Craen, Anton J. M., Westendorp, Rudi G. J., Boomsma, Dorret I., de Geus, Eco J. C., Houwing-Duistermaat, Jeanine J., Heijmans, Bastiaan T., Slagboom, P. Eline, Cantor, Charles R.

“…A set of currently known alleles increasing the risk for coronary artery disease, cancer, and type 2 diabetes as identified by genome-wide association studies…”
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Telomere length predicts survival independent of genetic influences by Bakaysa, Stephanie L., Mucci, Lorelei A., Slagboom, P. Eline, Boomsma, Dorret I., McClearn, Gerald E., Johansson, Boo, Pedersen, Nancy L.

“…Summary Telomeres prevent the loss of coding genetic material during chromosomal replication. Previous research suggests that shorter telomere length may be…”
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Transcriptional Associations of Osteoarthritis‐Mediated Loss of Epigenetic Control in Articular Cartilage by den Hollander, Wouter, Ramos, Yolande F. M., Bomer, Nils, Elzinga, Stefan, van der Breggen, Ruud, Lakenberg, Nico, de Dijcker, Wesley J., Suchiman, H. Eka D., Duijnisveld, Bouke J., Houwing‐Duistermaat, Jeanine J., Slagboom, P. Eline, Bos, Steffan D., Nelissen, Rob G. H. H., Meulenbelt, Ingrid

“…Objective To identify osteoarthritis (OA) progression–modulating pathways in articular cartilage and their respective regulatory epigenetic and genetic…”
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A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5′ UTR of GDF5 with osteoarthritis susceptibility by Chapman, Kay, Takahashi, Atsushi, Meulenbelt, Ingrid, Watson, Chris, Rodriguez-Lopez, Julio, Egli, Rainer, Tsezou, Aspasia, Malizos, Konstantinos N., Kloppenburg, Margreet, Shi, Dongquan, Southam, Lorraine, van der Breggen, Ruud, Donn, Rachelle, Qin, Jianghui, Doherty, Michael, Slagboom, P. Eline, Wallis, Gillian, Kamatani, Naoyuki, Jiang, Qing, Gonzalez, Antonio, Loughlin, John, Ikegawa, Shiro

“…We have performed a meta-analysis combining data for more than 11 000 individuals. It provides compelling evidence for a positive association between a…”
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The place of genetics in ageing research by Barzilai, Nir, Guarente, Leonard, Kirkwood, Thomas B. L., Partridge, Linda, Rando, Thomas A., Slagboom, P. Eline

“…Is ageing in our genes? In this Viewpoint, six experts present their views on the extent to which ageing is genetic and discuss future strategies for research…”
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Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity by Ruhaak, L Renee, Uh, Hae-Won, Beekman, Marian, Koeleman, Carolien A M, Hokke, Cornelis H, Westendorp, Rudi G J, Wuhrer, Manfred, Houwing-Duistermaat, Jeanine J, Slagboom, P Eline, Deelder, André M

“…Markers for longevity that reflect the health condition and predict healthy aging are extremely scarce. Such markers are, however, valuable in aging research…”
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Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis by Meulenbelt, Ingrid, Min, Josine L., Bos, Steffan, Riyazi, Naghmeh, Houwing-Duistermaat, Jeanine J., van der Wijk, Henk-Jan, Kroon, Herman M., Nakajima, Masahiro, Ikegawa, Shiro, Uitterlinden, André G., van Meurs, Joyce B.J., van der Deure, Wendy M., Visser, Theo J., Seymour, Albert B., Lakenberg, Nico, van der Breggen, Ruud, Kremer, Dennis, van Duijn, Cornelia M., Kloppenburg, Margreet, Loughlin, John, Slagboom, P. Eline

“…Osteoarthritis [MIM 165720] is a common late-onset articular joint disease for which no pharmaceutical intervention is available to attenuate the cartilage…”
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Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: Cross sectional and longitudinal studies by Soerensen, Mette, Dato, Serena, Tan, Qihua, Thinggaard, Mikael, Kleindorp, Rabea, Beekman, Marian, Jacobsen, Rune, Suchiman, H. Eka D., de Craen, Anton J.M., Westendorp, Rudi G.J., Schreiber, Stefan, Stevnsner, Tinna, Bohr, Vilhelm A., Slagboom, P. Eline, Nebel, Almut, Vaupel, James W., Christensen, Kaare, McGue, Matt, Christiansen, Lene

“…Here we explore association with human longevity of common genetic variation in three major candidate pathways: GH/IGF-1/insulin signaling, DNA damage…”
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A framework for the detection of de novo mutations in family-based sequencing data by Francioli, Laurent C, Cretu-Stancu, Mircea, Garimella, Kiran V, Fromer, Menachem, Kloosterman, Wigard P, Samocha, Kaitlin E, Neale, Benjamin M, Daly, Mark J, Banks, Eric, DePristo, Mark A, de Bakker, Paul Iw

“…Germline mutation detection from human DNA sequence data is challenging due to the rarity of such events relative to the intrinsic error rates of sequencing…”
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Genome-wide Association Study of Smoking Initiation and Current Smoking by Vink, Jacqueline M., Smit, August B., de Geus, Eco J.C., Sullivan, Patrick, Willemsen, Gonneke, Hottenga, Jouke-Jan, Smit, Johannes H., Hoogendijk, Witte J., Zitman, Frans G., Peltonen, Leena, Kaprio, Jaakko, Pedersen, Nancy L., Magnusson, Patrik K., Spector, Tim D., Kyvik, Kirsten Ohm, Morley, Katherine I., Heath, Andrew C., Martin, Nicholas G., Westendorp, Rudi G.J., Slagboom, P. Eline, Tiemeier, Henning, Hofman, Albert, Uitterlinden, Andre G., Aulchenko, Yurii S., Amin, Najaf, van Duijn, Cornelia, Penninx, Brenda W., Boomsma, Dorret I.

“…For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects…”
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