Search Results - "Slagboom, P. Eline"

Gut microbiome changes due to sleep disruption in older and younger individuals: a case for sarcopenia? by Morwani-Mangnani, Jordi, Giannos, Panagiotis, Belzer, Clara, Beekman, Marian, Eline Slagboom, P, Prokopidis, Konstantinos

“…Abstract Major hallmarks of functional loss, loss of metabolic and musculoskeletal health and (multi)morbidity with aging are associated with sleep…”
Get full text

DNA methylation signatures link prenatal famine exposure to growth and metabolism by Tobi, Elmar W., Goeman, Jelle J., Monajemi, Ramin, Gu, Hongcang, Putter, Hein, Zhang, Yanju, Slieker, Roderick C., Stok, Arthur P., Thijssen, Peter E., Müller, Fabian, van Zwet, Erik W., Bock, Christoph, Meissner, Alexander, Lumey, L. H., Eline Slagboom, P., Heijmans, Bastiaan T.

“…Periconceptional diet may persistently influence DNA methylation levels with phenotypic consequences. However, a comprehensive assessment of the…”
Get full text

Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population by Julkunen, Heli, Cichońska, Anna, Slagboom, P Eline, Würtz, Peter

“…Biomarkers of low-grade inflammation have been associated with susceptibility to a severe infectious disease course, even when measured prior to disease onset…”
Get full text

Functional Changes of T-Cell Subsets with Age and CMV Infection by Hassouneh, Fakhri, Goldeck, David, Pera, Alejandra, van Heemst, Diana, Slagboom, P. Eline, Pawelec, Graham, Solana, Rafael

“…Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function and phenotype of the T-cell pool. We have demonstrated that…”
Get full text

Phenome and genome based studies into human ageing and longevity: An overview by Eline Slagboom, P., van den Berg, Niels, Deelen, Joris

“…Human ageing is an extremely personal process leading across the life course of individuals to large population heterogeneity in the decline of functional…”
Get full text

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction by Victorelli, Stella, Lagnado, Anthony, Halim, Jessica, Moore, Will, Talbot, Duncan, Barrett, Karen, Chapman, James, Birch, Jodie, Ogrodnik, Mikolaj, Meves, Alexander, Pawlikowski, Jeff S, Jurk, Diana, Adams, Peter D, van Heemst, Diana, Beekman, Marian, Slagboom, P Eline, Gunn, David A, Passos, João F

“…Cellular senescence has been shown to contribute to skin ageing. However, the role of melanocytes in the process is understudied. Our data show that…”
Get full text

The continuing value of twin studies in the omics era by van Dongen, Jenny, Slagboom, P. Eline, Draisma, Harmen H. M., Martin, Nicholas G., Boomsma, Dorret I.

“…Key Points Twins are valuable subjects for studies in which control over genetic background and early environmental influences is desired. Monozygotic twins…”
Get full text

Small nucleoli are a cellular hallmark of longevity by Tiku, Varnesh, Jain, Chirag, Raz, Yotam, Nakamura, Shuhei, Heestand, Bree, Liu, Wei, Späth, Martin, Suchiman, H. Eka. D., Müller, Roman-Ulrich, Slagboom, P. Eline, Partridge, Linda, Antebi, Adam

“…Animal lifespan is regulated by conserved metabolic signalling pathways and specific transcription factors, but whether these pathways affect common downstream…”
Get full text

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals by Deelen, Joris, Kettunen, Johannes, Fischer, Krista, van der Spek, Ashley, Trompet, Stella, Kastenmüller, Gabi, Boyd, Andy, Zierer, Jonas, van den Akker, Erik B., Ala-Korpela, Mika, Amin, Najaf, Demirkan, Ayse, Ghanbari, Mohsen, van Heemst, Diana, Ikram, M. Arfan, van Klinken, Jan Bert, Mooijaart, Simon P., Peters, Annette, Salomaa, Veikko, Sattar, Naveed, Spector, Tim D., Tiemeier, Henning, Verhoeven, Aswin, Waldenberger, Melanie, Würtz, Peter, Davey Smith, George, Metspalu, Andres, Perola, Markus, Menni, Cristina, Geleijnse, Johanna M., Drenos, Fotios, Beekman, Marian, Jukema, J. Wouter, van Duijn, Cornelia M., Slagboom, P. Eline

“…Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics…”
Get full text

Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study by Ramos, Yolande F M, den Hollander, Wouter, Bovée, Judith V M G, Bomer, Nils, van der Breggen, Ruud, Lakenberg, Nico, Keurentjes, J Christiaan, Goeman, Jelle J, Slagboom, P Eline, Nelissen, Rob G H H, Bos, Steffan D, Meulenbelt, Ingrid

“…Identify gene expression profiles associated with OA processes in articular cartilage and determine pathways changing during the disease process. Genome wide…”
Get full text

RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage by Coutinho de Almeida, Rodrigo, Ramos, Yolande F M, Mahfouz, Ahmed, den Hollander, Wouter, Lakenberg, Nico, Houtman, Evelyn, van Hoolwerff, Marcella, Suchiman, H Eka D, Rodríguez Ruiz, Alejandro, Slagboom, P Eline, Mei, Hailiang, Kiełbasa, Szymon M, Nelissen, Rob G H H, Reinders, Marcel, Meulenbelt, Ingrid

“…To uncover the microRNA (miRNA) interactome of the osteoarthritis (OA) pathophysiological process in the cartilage. We performed RNA sequencing in 130 samples…”
Get more information

Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome by Tobi, Elmar W, Slieker, Roderick C, Stein, Aryeh D, Suchiman, H Eka D, Slagboom, P Eline, van Zwet, Erik W, Heijmans, Bastiaan T, Lumey, L H

“…The manipulation of pregnancy diets in animals can lead to changes in DNA methylation with phenotypic consequences in the offspring. Human studies have…”
Get full text

Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health by Plomp, Rosina, Ruhaak, L. Renee, Uh, Hae-Won, Reiding, Karli R., Selman, Maurice, Houwing-Duistermaat, Jeanine J., Slagboom, P. Eline, Beekman, Marian, Wuhrer, Manfred

“…This study indicates that glycosylation of immunoglobulin G, the most abundant antibody in human blood, may convey useful information with regard to…”
Get full text

Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait by van den Berg, Niels, Rodríguez-Girondo, Mar, van Dijk, Ingrid K., Mourits, Rick J., Mandemakers, Kees, Janssens, Angelique A. P. O., Beekman, Marian, Smith, Ken R., Slagboom, P. Eline

“…Survival to extreme ages clusters within families. However, identifying genetic loci conferring longevity and low morbidity in such longevous families is…”
Get full text

Persistent epigenetic differences associated with prenatal exposure to famine in humans by Heijmans, Bastiaan T, Tobi, Elmar W, Stein, Aryeh D, Putter, Hein, Blauw, Gerard J, Susser, Ezra S, Slagboom, P. Eline, Lumey, L.H

“…Extensive epidemiologic studies have suggested that adult disease risk is associated with adverse environmental conditions early in development. Although the…”
Get full text

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific by Tobi, Elmar W., Lumey, L.H., Talens, Rudolf P., Kremer, Dennis, Putter, Hein, Stein, Aryeh D., Slagboom, P. Eline, Heijmans, Bastiaan T.

“…Prenatal famine in humans has been associated with various later-life consequences, depending on the gestational timing of the insult and the sex of the…”
Get full text

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults by Chen, Sijia, Pawelec, Graham, Trompet, Stella, Goldeck, David, Mortensen, Laust H, Slagboom, P Eline, Christensen, Kaare, Gussekloo, Jacobijn, Kearney, Patricia, Buckley, Brendan M, Ford, Ian, Jukema, J Wouter, Westendorp, Rudi G J, Maier, Andrea B

“…Abstract Background Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought…”
Get full text

Physical activity and fiber intake beneficial for muscle mass and strength preservation during aging: A comprehensive cross-sectional study in the UK biobank cohort by Morwani-Mangnani, Jordi, Rodriguez-Girondo, Mar, Singh-Povel, Cecile, Verlaan, Sjors, Beekman, Marian, Slagboom, P. Eline

“…Aging triggers intricate physiological changes, particularly in whole-body fat-free mass (FFM) and handgrip strength, affecting overall health and…”
Get full text

Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease by Surowiec, Izabella, Noordam, Raymond, Bennett, Kate, Beekman, Marian, Slagboom, P. Eline, Lundstedt, Torbjörn, van Heemst, Diana

“…Background We aimed to identify novel metabolite and lipid signatures connected with the metabolic syndrome in a Dutch middle-aged population. Methods 115…”
Get full text

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception by Slieker, Roderick C, Relton, Caroline L, Gaunt, Tom R, Slagboom, P Eline, Heijmans, Bastiaan T

“…The well-established association of chronological age with changes in DNA methylation is primarily founded on the analysis of large sets of blood samples,…”
Get full text