Search Results - "Sladky, Valentina"

Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation by Sladky, Valentina C., Villunger, Andreas

“…The PIDDosome is a multiprotein complex that drives activation of caspase-2, an endopeptidase originally implicated in apoptosis. Yet, unlike other caspases…”
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Polyploidy control in hepatic health and disease by Sladky, Valentina C., Eichin, Felix, Reiberger, Thomas, Villunger, Andreas

“…A balanced increase in DNA content (ploidy) is observed in some human cell types, including bone-resorbing osteoclasts, platelet-producing megakaryocytes,…”
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The resurrection of the PIDDosome - emerging roles in the DNA-damage response and centrosome surveillance by Sladky, Valentina, Schuler, Fabian, Fava, Luca L, Villunger, Andreas

“…The PIDDosome is often used as the alias for a multi-protein complex that includes the p53-induced death domain protein 1 (PIDD1), the bipartite linker protein…”
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The PIDDosome activates p53 in response to supernumerary centrosomes by Fava, Luca L, Schuler, Fabian, Sladky, Valentina, Haschka, Manuel D, Soratroi, Claudia, Eiterer, Lisa, Demetz, Egon, Weiss, Guenter, Geley, Stephan, Nigg, Erich A, Villunger, Andreas

“…Centrosomes, the main microtubule-organizing centers in animal cells, are replicated exactly once during the cell division cycle to form the poles of the…”
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PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis by Kim, Ju Youn, Wang, Lily Q., Sladky, Valentina C., Oh, Tae Gyu, Liu, Junlai, Trinh, Kaitlyn, Eichin, Felix, Downes, Michael, Hosseini, Mojgan, Jacotot, Etienne D., Evans, Ronald M., Villunger, Andreas, Karin, Michael

“…Sterol deficiency triggers SCAP-mediated SREBP activation, whereas hypernutrition together with ER-stress activate SREBP1/2 via caspase-2. Whether these…”
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E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration by Sladky, Valentina C., Knapp, Katja, Soratroi, Claudia, Heppke, Julia, Eichin, Felix, Rocamora-Reverte, Lourdes, Szabo, Tamas G., Bongiovanni, Laura, Westendorp, Bart, Moreno, Eva, van Liere, Elsbeth A., Bakker, Bjorn, Spierings, Diana C.J., Wardenaar, René, Pereyra, David, Starlinger, Patrick, Schultze, Simon, Trauner, Michael, Stojakovic, Tatjana, Scharnagl, Hubert, Fava, Luca L., Foijer, Floris, de Bruin, Alain, Villunger, Andreas

“…E2F transcription factors control the cytokinesis machinery and thereby ploidy in hepatocytes. If or how these proteins limit proliferation of polyploid cells…”
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PIDDosome‐induced p53‐dependent ploidy restriction facilitates hepatocarcinogenesis by Sladky, Valentina C, Knapp, Katja, Szabo, Tamas G, Braun, Vincent Z, Bongiovanni, Laura, van den Bos, Hilda, Spierings, Diana CJ, Westendorp, Bart, Curinha, Ana, Stojakovic, Tatjana, Scharnagl, Hubert, Timelthaler, Gerald, Tsuchia, Kaoru, Pinter, Matthias, Semmler, Georg, Foijer, Floris, de Bruin, Alain, Reiberger, Thomas, Rohr‐Udilova, Nataliya, Villunger, Andreas

“…Polyploidization frequently precedes tumorigenesis but also occurs during normal development in several tissues. Hepatocyte ploidy is controlled by the…”
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Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis by Lambrecht, Rebekka, Rudolf, Franziska, Ückert, Anna-Katharina, Sladky, Valentina C., Phan, Truong San, Jansen, Jasmin, Naim, Samara, Kaufmann, Thomas, Keogh, Adrian, Kirschnek, Susanne, Mangerich, Aswin, Stengel, Florian, Leist, Marcel, Villunger, Andreas, Brunner, Thomas

“…Paracetamol (acetaminophen, APAP) overdose severely damages mitochondria and triggers several apoptotic processes in hepatocytes, but the final outcome is…”
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Centriole signaling restricts hepatocyte ploidy to maintain liver integrity by Sladky, Valentina C, Akbari, Hanan, Tapias-Gomez, Daniel, Evans, Lauren T, Drown, Chelsea G, Strong, Margaret A, LoMastro, Gina M, Larman, Tatianna, Holland, Andrew J

“…Hepatocyte polyploidization is a tightly controlled process that is initiated at weaning and increases with age. The proliferation of polyploid hepatocytes in…”
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Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability by Sheikh, Taimoor I., Vasli, Nasim, Pastore, Stephen, Kharizi, Kimia, Harripaul, Ricardo, Fattahi, Zohreh, Pande, Shruti, Naeem, Farooq, Hussain, Abrar, Mir, Asif, Islam, Omar, Girisha, Katta Mohan, Irfan, Muhammad, Ayub, Muhammad, Schwarzer, Christoph, Najmabadi, Hossein, Shukla, Anju, Sladky, Valentina C., Braun, Vincent Zoran, Garcia-Carpio, Irmina, Villunger, Andreas, Vincent, John B.

“…PIDD1 encodes p53-Induced Death Domain protein 1, which acts as a sensor surveilling centrosome numbers and p53 activity in mammalian cells. Early results also…”
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BOK promotes chemical-induced hepatocarcinogenesis in mice by Rabachini, Tatiana, Fernandez-Marrero, Yuniel, Montani, Matteo, Loforese, Giulio, Sladky, Valentina, He, Zhaoyue, Bachmann, Daniel, Wicki, Simone, Villunger, Andreas, Stroka, Deborah, Kaufmann, Thomas

“…BCL-2-related ovarian killer (BOK) is a conserved and widely expressed BCL-2 family member with sequence homology to pro-apoptotic BAX and BAK, but with poorly…”
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FRI503 - Piddosome-controlled liver ploidy is predictive for HCC outcome by Sladky, Valentina, Knapp, Katja, Tsuchiya, Kaoru, Bongiovanni, Laura, Westendorp, Bart, Szabo, Tamas, Timelthaler, Gerald, Eferl, Robert, Sieghart, Wolfgang, Peck-Radosavljevic, Markus, Herac, Merima, Stift, Judith, Oberhuber, Georg, Stojakovic, Tatjana, Schargl, Hubert, van den Bos, Hilda, Spierings, Diana, Foijer, Floris, de Bruin, Alain, Pinter, Matthias, Reiberger, Thomas, Rohr-Udilova, Nataliya, Villunger, Andreas

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Piddosome-controlled liver ploidy is predictive for HCC outcome by Sladky, Valentina, Knapp, Katja, Tsuchiya, Kaoru, Bongiovanni, Laura, Westendorp, Bart, Szabo, Tamas, Timelthaler, Gerald, Eferl, Robert, Sieghart, Wolfgang, Peck-Radosavljevic, Markus, Herac, Merima, Stift, Judith, Oberhuber, Georg, Stojakovic, Tatjana, Schargl, Hubert, van den Bos, Hilda, Spierings, Diana, Foijer, Floris, de Bruin, Alain, Pinter, Matthias, Reiberger, Thomas, Rohr-Udilova, Nataliya, Villunger, Andreas

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