Search Results - "Sladka, M."

Relevant animal model of human lymphoblastic leukaemia/lymphoma--spontaneous T-cell lymphomas in an inbred Sprague-Dawley rat strain (SD/Cub) by Otová, B, Sladká, M, Damoiseaux, J, Panczak, A, Mandys, V, Marinov, I

“…More than a decade of experimental work in an inbred subline of Sprague-Dawley rats having high incidence of spontaneous T-cell lymphoma/leukaemia is reviewed…”
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9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP)--a potential drug against hematological malignancies--induces apoptosis by Otová, B, Francová, K, Franĕk, F, Koutník, P, Votruba, I, Holy, A, Sladká, M, Schramlová, J

“…Antitumor activity of the acyclic nucleotide analogs PMEDAP, PMEA, and PMEG was studied on a model of a spontaneous T-cell lymphoma in inbred SD/cub rats…”
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Biological characteristics of spontaneous transplantable T-cell lymphomas in inbred Sprague-Dawley/cub rats by Otová, B., Sladká, M., Panczak, A., Marinov, I.

“…The incidence of hematological malignancies in the Prague inbred line of Sprague-Dawley (SD) rats was originally reported as 17% in animals of both sexes…”
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Characterization of T-cell lymphomas in the Prague inbred Sprague-Dawley/cub rat strain: a model of spontaneous hematologic malignancy by Otová, B, Sladká, M, Damoiseaux, J, Panczak, A, Mandys, V, Francová, K, Kudláčková, M

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Chromosome assignment of Cd36 transgenes in two rat SHR lines by FISH and linkage mapping of transgenic insert in the SHR-TG19 line by Liska, F, Levan, G, Helou, K, Sladká, M, Pravenec, M, Zídek, V, Landa, V, Kren, V

“…The chromosome position of the Cd36 insert was determined by FISH in two rat transgenic lines (SHR/Ola-TgN(EF1aCd36)10Ipcv (SHR-TG10) and…”
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Cytogenetic changes in Sprague-Dawley rat lymphomas in the course of in vivo passages by Sladká, M, Otová, B

“…Changes in the karyotype in three spontaneous Sprague-Dawley rat lymphomas (SD7/95, SD8/96, SD9/96) have been studied in the course of in vivo passages. In…”
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Genetic analysis of graft-versus-host disease using rat recombinant inbred strains by Panczak, A., Bila, V., Sladka, M., Křenová, D., Otová, B., Pravenec, M., Křen, V.

“…Raft-versus-host disease (GVHD) is known to be an extremely complex alloantigenic reaction. 1 In our work, we intended to analyze the contribution of RT1 and…”
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Antitumor activity of novel purine acyclic nucleotide analogs PMEA and PMEDAP by Otová, B, Zídek, Z, Holý, A, Votruba, I, Sladká, M, Marinov, I, Lesková, V

“…PMEDAP and/or PMEA treatment of SD rat lymphomas significantly prolonged the mean survival time of tumor-bearing animals. Dose-dependent genotoxicity of both…”
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Graft-versus-host disease in the rat: A genetic analysis in recombinant inbred strains of SHR x BN. Lx and BN. Lx x SHR sets by PANCZAK, A, KREN, V, BILA, V, PRAVENEC, M, MATOUSKOVA, M, KRENOVA, D, OTOVA, B, SLADKA, M

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Inhibition of acute graft-versus-host disease in (LEW.1W x LEW.1A)F1 rats using 9-(2-phosphonomethoxyethyl)-2,6-diaminopurine by OTOVA, B, PANCZAK, A, KOHOUTOVA, M, BLAZEK, K, SCHRAMLOVA, J, SLADKA, M, HOLY, A

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Genotoxicity of purine acyclic nucleotide analogs by Otová, B, Holý, A, Votruba, I, Sladká, M, Bílá, V, Mejsnarová, B, Lesková, V

“…The genotoxic and embryotoxic effects of phosphonomethoxyalkylpurines, a new group of antiviral agents, decrease in the following order: PMEG > PMEthioG >…”
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Inhibition of acute graft-versus-host disease in (LEW.1W × lew.1A)F 1 rats using 9-(2-phosphonomethoxyethyl)-2,6-diaminopurine by Otová, B., Panczak, A., Kohoutová, M., Blažek, K., Schramlová, J., Sladká, M., Holý, A.

“…(2-PHOSPHONOMETHOXYETHYL)-2,6-diaminopurine (PMEDAP) is a novel purine acyclic nucleotide analog with powerful antiviral potency directed against a broad…”
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Chromosome 11 participation in acute lymphoblastic leukaemia in Sprague-Dawley rats by Sladká, M, Otová, B

“…Five cases of spontaneous acute lymphoblastic leukaemias (ALL) of Sprague-Dawley (SD) inbred rats have been studied cytogenetically. Chromosome studies were…”
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Question of homology between rat chromosome 8 and mouse chromosome 9 by Sladká, M, Kren, V, Pravenec, M

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Model of acute graft-vs-host-disease in adult (SHR x BN.lx)F1 rats and its inhibition by adenine analog by Kren, V, Otová, B, Elleder, D, Elleder, M, Panczak, A, Sladká, M

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Antimitotic and teratogenic effects of acyclic nucleotide analogues 1-(S)-(3-hydroxy-2-phosphonomethoxyethyl)cytosine (HPMPC) and 9-(2-phosphonomethoxyethyl) adenine (PMEA) by Bílá, V, Otová, B, Jelínek, R, Sladká, M, Mejsnarová, B, Holý, A, Kren, V

“…The acyclic nucleotide analogues, HPMPC and PMEA, differ in their in vitro effect on the genetic material of eukaryotic cells. While HPMPC exerts a cytostatic…”
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Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats by Otová, B, Sladká, M, Votruba, I, Holý, A, Kren, V

“…PMEA was administered i.p. daily on 10 consecutive days to inbred LEW rats inoculated with leukemic lymphoblastic cells KPH-Lw-I. The treatment was started 24…”
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Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats by Otová, B, Sladká, M, Blazek, K, Schramlová, J, Votruba, I, Holý, A

“…Two cases of spontaneous acute lymphoblastic leukemia in the inbred strain of Sprague-Dawley (Prague) rats have been observed. Since its reliable…”
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Spontaneous lymphoblastic leukemia in SD/Ipcv rats: transplantation and chromosomal analysis by Klír, P, Sladká, M, Pravenec, M, Pribylová, M

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G-banding chromosome studies of acute lymphoblastic Lewis rat leukemia (KPH-Lw-I) by Sladká, M, Kremen, J, Kren, V

“…Changes of karyotype in spontaneous acute lymphoblastic Lewis rat leukemia have been studied by conventional Giemsa staining method and by G- and C-banding…”
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