Search Results - "Slade, Luke"

Hydrogen sulfide supplementation as a potential treatment for primary mitochondrial diseases by Slade, Luke, Deane, Colleen S., Szewczyk, Nathaniel J., Etheridge, Timothy, Whiteman, Matthew

“…Primary mitochondrial diseases (PMD) are amongst the most common inborn errors of metabolism causing fatal outcomes within the first decade of life. With…”
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An evaluation of the role of miR-361-5p in senescence and systemic ageing by Manni, Emad, Jeffery, Nicola, Chambers, David, Slade, Luke, Etheridge, Timothy, Harries, Lorna W.

“…Senescent cells are key regulators of ageing and age-associated disease. MicroRNAs (miRs) are a key component of the molecular machinery governing cellular…”
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Bisphosphonates attenuate age‐related muscle decline in Caenorhabditis elegans by Slade, Luke, Bollen, Shelby E., Bass, Joseph J., Phillips, Bethan E., Smith, Kenneth, Wilkinson, Daniel J., Szewczyk, Nathaniel J., Atherton, Philip J., Etheridge, Timothy

“…Background Age‐related muscle decline (sarcopenia) associates with numerous health risk factors and poor quality of life. Drugs that counter sarcopenia without…”
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Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy by Ellwood, Rebecca A., Slade, Luke, Lewis, Jonathan, Torregrossa, Roberta, Sudevan, Surabhi, Piasecki, Mathew, Whiteman, Matthew, Etheridge, Timothy, Szewczyk, Nathaniel J.

“…Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD), a common muscle disease that manifests with muscle weakness, wasting, and…”
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Global persulfidome changes in aging C. elegans by Filipovic, Milos, Petrovic, Dunja, Slade, Luke

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Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline by Slade, Luke, Etheridge, Timothy, Szewczyk, Nathaniel J.

“…Understanding mechanisms of ageing remains a complex challenge for biogerontologists, but recent adaptations of evolutionary ageing theories offer a compelling…”
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The mitochondria‐targeted hydrogen sulfide donor AP39 improves health and mitochondrial function in a C. elegans primary mitochondrial disease model by Fox, Bridget C., Slade, Luke, Torregrossa, Roberta, Pacitti, Dario, Szabo, Csaba, Etheridge, Timothy, Whiteman, Matthew

“…Primary mitochondrial diseases (PMD) are inherited diseases that cause dysfunctional mitochondrial oxidative phosphorylation, leading to diverse multisystem…”
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Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans by Vintila, Adriana Raluca, Slade, Luke, Cooke, Michael, Willis, Craig R G, Torregrossa, Roberta, Rahman, Mizanur, Anupom, Taslim, Vanapalli, Siva A, Gaffney, Christopher J, Gharahdaghi, Nima, Szabo, Csaba, Szewczyk, Nathaniel J, Whiteman, Matthew, Etheridge, Timothy

“…Living longer without simultaneously extending years spent in good health ("health span") is an increasing societal burden, demanding new therapeutic…”
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Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model by Ellwood, Rebecca A., Hewitt, Jennifer E., Torregrossa, Roberta, Philp, Ashleigh M., Hardee, Justin P., Hughes, Samantha, van de Klashorst, David, Gharahdaghi, Nima, Anupom, Taslim, Slade, Luke, Deane, Colleen S., Cooke, Michael, Etheridge, Timothy, Piasecki, Mathew, Antebi, Adam, Lynch, Gordon S., Philp, Andrew, Vanapalli, Siva A., Whiteman, Matthew, Szewczyk, Nathaniel J.

“…Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle degeneration and weakness due to mutations in the…”
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