Search Results - "Slack, Ruth S."

Mitochondrial dynamics in the regulation of neurogenesis: From development to the adult brain by Khacho, Mireille, Slack, Ruth S.

“…Mitochondria are classically known to be the cellular energy producers, but a renewed appreciation for these organelles has developed with the accumulating…”
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Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons by Pacelli, Consiglia, Giguère, Nicolas, Bourque, Marie-Josée, Lévesque, Martin, Slack, Ruth S., Trudeau, Louis-Éric

“…Although the mechanisms underlying the loss of neurons in Parkinson’s disease are not well understood, impaired mitochondrial function and pathological protein…”
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Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program by Khacho, Mireille, Clark, Alysen, Svoboda, Devon S., Azzi, Joelle, MacLaurin, Jason G., Meghaizel, Cynthia, Sesaki, Hiromi, Lagace, Diane C., Germain, Marc, Harper, Mary-Ellen, Park, David S., Slack, Ruth S.

“…Regulated mechanisms of stem cell maintenance are key to preventing stem cell depletion and aging. While mitochondrial morphology plays a fundamental role in…”
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OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand by Patten, David A, Wong, Jacob, Khacho, Mireille, Soubannier, Vincent, Mailloux, Ryan J, Pilon-Larose, Karine, MacLaurin, Jason G, Park, David S, McBride, Heidi M, Trinkle-Mulcahy, Laura, Harper, Mary-Ellen, Germain, Marc, Slack, Ruth S

“…Cristae, the organized invaginations of the mitochondrial inner membrane, respond structurally to the energetic demands of the cell. The mechanism by which…”
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PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress by Huang, En, Qu, Dianbo, Huang, Tianwen, Rizzi, Nicoletta, Boonying, Wassamon, Krolak, Dorothy, Ciana, Paolo, Woulfe, John, Klein, Christine, Slack, Ruth S., Figeys, Daniel, Park, David S.

“…Mutations in PTEN-induced kinase 1 (PINK1) result in a recessive familial form of Parkinson’s disease (PD). PINK1 loss is associated with mitochondrial Ca 2+…”
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Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals by Antoun, Ghadi, McMurray, Fiona, Thrush, A. Brianne, Patten, David A., Peixoto, Alyssa C., Slack, Ruth S., McPherson, Ruth, Dent, Robert, Harper, Mary-Ellen

“…Aims/hypothesis Skeletal muscle mitochondrial dysfunction has been documented in patients with type 2 diabetes mellitus; however, specific respiratory defects…”
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Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease by Kim, Kwang Soo, Marcogliese, Paul C., Yang, Jungwoo, Callaghan, Steve M., Resende, Virginia, Abdel-Messih, Elizabeth, Marras, Connie, Visanji, Naomi P., Huang, Jana, Schlossmacher, Michael G., Trinkle-Mulcahy, Laura, Slack, Ruth S., Lang, Anthony E., Park, David S.

“…Leucine-rich repeat kinase 2 (LRRK2) has been implicated in both familial and sporadic Parkinson’s disease (PD), yet its pathogenic role remains unclear. A…”
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Comparative analysis of Parkinson's disease–associated genes in mice reveals altered survival and bioenergetics of Parkin-deficient dopamine neurons by Giguère, Nicolas, Pacelli, Consiglia, Saumure, Caroline, Bourque, Marie-Josée, Matheoud, Diana, Levesque, Daniel, Slack, Ruth S., Park, David S., Trudeau, Louis-Éric

“…Many mutations in genes encoding proteins such as Parkin, PTEN-induced putative kinase 1 (PINK1), protein deglycase DJ-1 (DJ-1 or PARK7), leucine-rich repeat…”
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Mitochondria as central regulators of neural stem cell fate and cognitive function by Khacho, Mireille, Harris, Richard, Slack, Ruth S.

“…Emerging evidence now indicates that mitochondria are central regulators of neural stem cell (NSC) fate decisions and are crucial for both neurodevelopment and…”
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Neonatal hyperoxia in mice triggers long-term cognitive deficits via impairments in cerebrovascular function and neurogenesis by Lithopoulos, Marissa A., Toussay, Xavier, Zhong, Shumei, Xu, Liqun, Mustafa, Shamimunisa B., Ouellette, Julie, Freitas-Andrade, Moises, Comin, Cesar H., Bassam, Hayam A., Baker, Adam N., Sun, Yiren, Wakem, Michael, Moreira, Alvaro G., Blanco, Cynthia L., Vadivel, Arul, Tsilfidis, Catherine, Seidner, Steven R., Slack, Ruth S., Lagace, Diane C., Wang, Jing, Lacoste, Baptiste, Thébaud, Bernard

“…Preterm birth is the leading cause of death in children under 5 years of age. Premature infants who receive life-saving oxygen therapy often develop…”
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Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP by Haque, M. Emdadul, Thomas, Kelly J, D'Souza, Cheryl, Callaghan, Steve, Kitada, Tohru, Slack, Ruth S, Fraser, Paul, Cookson, Mark R, Tandon, Anurag, Park, David S

“…PTEN-induced putative kinase 1 (Pink1) is a recently identified gene linked to a recessive form of familial Parkinson's disease (PD). The kinase contains a…”
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MCL-1 regulates the balance between autophagy and apoptosis by Germain, Marc, Slack, Ruth S.

“…BCL-2 homologues lie at the interface between apoptosis and autophagy, regulating these two critical cellular pathways. However, the mechanisms controlling…”
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PFTK1 kinase regulates axogenesis during development via RhoA activation by González, Yasmilde Rodríguez, Kamkar, Fatemeh, Jafar-nejad, Paymaan, Wang, Suzi, Qu, Dianbo, Alvarez, Leticia Sanchez, Hawari, Dina, Sonnenfeld, Margaret, Slack, Ruth S, Albert, Paul R, Park, David S, Joselin, Alvin

“…Abstract Background PFTK1/Eip63E is a member of the cyclin-dependent kinases (CDKs) family and plays an important role in normal cell cycle progression. Eip63E…”
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Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer’s disease by Liu, Yubing, Bilen, Maria, McNicoll, Marie-Michelle, Harris, Richard A., Fong, Bensun C., Iqbal, Mohamed Ariff, Paul, Smitha, Mayne, Janice, Walker, Krystal, Wang, Jing, Figeys, Daniel, Slack, Ruth S.

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disorder leading to dementia. The hippocampus, which is one of the sites where neural stem cells…”
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BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival by Qu, Dianbo, Hage, Ali, Don-Carolis, Katie, Huang, En, Joselin, Alvin, Safarpour, Farzaneh, Marcogliese, Paul C., Rousseaux, Maxime W.C., Hewitt, Sarah J., Huang, Tianwen, Im, Doo-Soon, Callaghan, Steve, Dewar-Darch, Danielle, Figeys, Daniel, Slack, Ruth S., Park, David S.

“…Emerging evidence has demonstrated a growing genetic component in Parkinson disease (PD). For instance, loss-of-function mutations in PINK1 or PARKIN can cause…”
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Opposing Regulation of Sox2 by Cell-Cycle Effectors E2f3a and E2f3b in Neural Stem Cells by Julian, Lisa M., Vandenbosch, Renaud, Pakenham, Catherine A., Andrusiak, Matthew G., Nguyen, Angela P., McClellan, Kelly A., Svoboda, Devon S., Lagace, Diane C., Park, David S., Leone, Gustavo, Blais, Alexandre, Slack, Ruth S.

“…The mechanisms through which cell-cycle control and cell-fate decisions are coordinated in proliferating stem cell populations are largely unknown. Here, we…”
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The Mitochondrial Inner Membrane GTPase, Optic Atrophy 1 (Opa1), Restores Mitochondrial Morphology and Promotes Neuronal Survival following Excitotoxicity by Jahani-Asl, Arezu, Pilon-Larose, Karine, Xu, William, MacLaurin, Jason G., Park, David S., McBride, Heidi M., Slack, Ruth S.

“…Mitochondrial dynamics have been extensively studied in the context of classical cell death models involving Bax-mediated cytochrome c release. Excitotoxic…”
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Role of AIF in caspase-dependent and caspase-independent cell death by Cregan, Sean P, Dawson, Valina L, Slack, Ruth S

“…The major challenge in treating cancer is that many tumor cells carry mutations in key apoptotic genes such as p53, Bcl family proteins or those affecting…”
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The pro-death role of Cited2 in stroke is regulated by E2F1/4 transcription factors by Huang, Tianwen, González, Yasmilde Rodríguez, Qu, Dianbo, Huang, En, Safarpour, Farzaneh, Wang, Eugene, Joselin, Alvin, Im, Doo Soon, Callaghan, Steve M., Boonying, Wassamon, Julian, Lisa, Dunwoodie, Sally L., Slack, Ruth S., Park, David S.

“…We previously reported that the cell cycle–related cyclin-dependent kinase 4–retinoblastoma (RB) transcriptional corepressor pathway is essential for…”
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Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition by Im, Doo Soon, Joselin, Alvin, Svoboda, Devon, Takano, Tesuya, Rousseaux, Maxime W C, Callaghan, Steve, Slack, Ruth S, Hisanaga, Shin-Ichi, Davis, Roger J, Park, David S, Qu, Dianbo

“…Activated Cdk5 regulates a number of processes during nervous system formation, including neuronal differentiation, growth cone stabilization, and axonal…”
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