Search Results - "Slack, Jay P."

Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans by Lossow, Kristina, Hübner, Sandra, Roudnitzky, Natacha, Slack, Jay P., Pollastro, Federica, Behrens, Maik, Meyerhof, Wolfgang

“…One key to animal survival is the detection and avoidance of potentially harmful compounds by their bitter taste. Variable numbers of taste 2 receptor genes…”
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The Molecular Basis of Individual Differences in Phenylthiocarbamide and Propylthiouracil Bitterness Perception by Bufe, Bernd, Breslin, Paul A.S., Kuhn, Christina, Reed, Danielle R., Tharp, Christopher D., Slack, Jay P., Kim, Un-Kyung, Drayna, Dennis, Meyerhof, Wolfgang

“…Individual differences in perception are ubiquitous within the chemical senses: taste, smell, and chemical somesthesis [1–4]. A hypothesis of this fact states…”
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Modulation of Bitter Taste Perception by a Small Molecule hTAS2R Antagonist by Slack, Jay P., Brockhoff, Anne, Batram, Claudia, Menzel, Susann, Sonnabend, Caroline, Born, Stephan, Galindo, Maria Mercedes, Kohl, Susann, Thalmann, Sophie, Ostopovici-Halip, Liliana, Simons, Christopher T., Ungureanu, Ioana, Duineveld, Kees, Bologa, Cristian G., Behrens, Maik, Furrer, Stefan, Oprea, Tudor I., Meyerhof, Wolfgang

“…Human bitter taste is mediated by the hTAS2R family of G protein-coupled receptors [1–4]. The discovery of the hTAS2Rs enables the potential to develop…”
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Differential modulation of the lactisole 'Sweet Water Taste' by sweeteners by Alvarado, Cynthia, Nachtigal, Danielle, Slack, Jay P, Green, Barry G

“…Pre-exposure to taste stimuli and certain chemicals can cause water to have a taste. Here we studied further the 'sweet water taste' (SWT) perceived after…”
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Bitter Taste Receptors for Saccharin and Acesulfame K by Kuhn, Christina, Bufe, Bernd, Winnig, Marcel, Hofmann, Thomas, Frank, Oliver, Behrens, Maik, Lewtschenko, Tatjana, Slack, Jay P, Ward, Cynthia D, Meyerhof, Wolfgang

“…Weight-conscious subjects and diabetics use the sulfonyl amide sweeteners saccharin and acesulfame K to reduce their calorie and sugar intake. However, the…”
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Association between Common Variation in Genes Encoding Sweet Taste Signaling Components and Human Sucrose Perception by Fushan, Alexey A., Simons, Christopher T., Slack, Jay P., Drayna, Dennis

“…Variation in taste perception of different chemical substances is a well-known phenomenon in both humans and animals. Recent advances in the understanding of…”
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In Vitro Evaluation of Flavonoids from Eriodictyon californicum for Antagonist Activity against the Bitterness Receptor hTAS2R31 by Fletcher, Joshua N, Kinghorn, A. Douglas, Slack, Jay P, McCluskey, T. Scott, Odley, Amy, Jia, Zhonghua

“…The leaves of the native North American plant, Eriodictyon californicum, were once used to mask the bitter taste of pharmaceuticals, an application currently…”
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In Vitro Evaluation of Potential Bitterness-Masking Terpenoids from the Canada Goldenrod (Solidago canadensis) by Li, Jie, Pan, Li, Fletcher, Joshua N, Lv, Wei, Deng, Ye, Vincent, Michael A, Slack, Jay P, McCluskey, T. Scott, Jia, Zhonghua, Cushman, Mark, Kinghorn, A. Douglas

“…In a screening of extracts of selected plants native to Ohio against the human bitterness receptor hTAS2R31, a chloroform-soluble extract of the aerial parts…”
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The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor by Winnig, Marcel, Bufe, Bernd, Kratochwil, Nicole A, Slack, Jay P, Meyerhof, Wolfgang

“…Differences in sweet taste perception among species depend on structural variations of the sweet taste receptor. The commercially used isovanillyl sweetener…”
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A tingling sanshool derivative excites primary sensory neurons and elicits nocifensive behavior in rats by Klein, Amanda H, Sawyer, Carolyn M, Zanotto, Karen L, Ivanov, Margaret A, Cheung, Susan, Carstens, Mirela Iodi, Furrer, Stephan, Simons, Christopher T, Slack, Jay P, Carstens, E

“…Szechuan peppers contain hydroxy-α-sanshool that imparts desirable tingling, cooling, and numbing sensations. Hydroxy-α-sanshool activates a subset of sensory…”
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Sarco/Endoplasmic reticulum Ca2+-ATPases (SERCA) contribute to GPCR-mediated taste perception by Iguchi, Naoko, Ohkuri, Tadahiro, Slack, Jay P, Zhong, Ping, Huang, Liquan

“…The sense of taste is important for providing animals with valuable information about the qualities of food, such as nutritional or harmful nature. Mammals,…”
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G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey by Kratochwil, Nicole A, Gatti-McArthur, Silvia, Hoener, Marius C, Lindemann, Lothar, Christ, Andreas D, Green, Luke G, Guba, Wolfgang, Martin, Rainer E, Malherbe, Pari, Porter, Richard H P, Slack, Jay P, Winnig, Marcel, Dehmlow, Henrietta, Grether, Uwe, Hertel, Cornelia, Narquizian, Robert, Panousis, Constantinos G, Kolczewski, Sabine, Steward, Lucinda

“…G protein-coupled receptors (GPCRs) share a common architecture consisting of seven transmembrane (TM) domains. Various lines of evidence suggest that this…”
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Allelic Polymorphism within the TAS1R3 Promoter Is Associated with Human Taste Sensitivity to Sucrose by Fushan, Alexey A., Simons, Christopher T., Slack, Jay P., Manichaikul, Ani, Drayna, Dennis

“…Human sweet taste perception is mediated by the heterodimeric G protein-coupled receptor encoded by the TAS1R2 and TAS1R3 genes [1–7]. Variation in these genes…”
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Phospholamban Gene Dosage Effects in the Mammalian Heart by Luo, Wusheng, Wolska, Beata M, Grupp, Ingrid L, Harrer, Judy M, Haghighi, Kobra, Ferguson, Donald G, Slack, Jay P, Grupp, Gunter, Doetschman, Thomas, Solaro, R. John, Kranias, Evangelia G

“…Phospholamban ablation has been shown to result in significant increases in cardiac contractile parameters and loss of beta-adrenergic stimulation. To…”
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Novel Menthol-Derived Cooling Compounds Activate Primary and Second-Order Trigeminal Sensory Neurons and Modulate Lingual Thermosensitivity by Klein, Amanda H, Iodi Carstens, Mirela, McCluskey, T. Scott, Blancher, Guillaume, Simons, Christopher T, Slack, Jay P, Furrer, Stefan, Carstens, Earl

“…We presently investigated 2 novel menthol derivatives GIV1 and GIV2, which exhibit strong cooling effects. In previous human psychophysical studies, GIV1…”
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New Developments in the Chemistry of Cooling Compounds by Furrer, Stefan M., Slack, Jay P., McCluskey, Scott T., Ungureanu, Ioana M., Daniher, Andrew T., Blancher, Guillaume, Bell, Karen, Krawec, Pablo, Cole, Lucienne, Gray, Kim

“…Cooling chemicals play a fundamental role in the flavor and fragrance industry. Traditional trial-and-error techniques led in the past to the discovery of…”
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Compensatory Mechanisms Associated With the Hyperdynamic Function of Phospholamban-Deficient Mouse Hearts by Chu, Guoxiang, Luo, Wusheng, Slack, Jay P, Tilgmann, Carola, Sweet, Wendy E, Spindler, Matthias, Saupe, Kurt W, Boivin, Gregory P, Moravec, Christine S, Matlib, Mohammed A, Grupp, Ingrid L, Ingwall, Joanne S, Kranias, Evangelia G

“…Phospholamban ablation is associated with significant increases in the sarcoplasmic reticulum Ca sup 2+-ATPase activity and the basal cardiac contractile…”
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Phospholamban ablation enhances relaxation in the murine soleus by Slack, J P, Grupp, I L, Luo, W, Kranias, E G

“…Phospholamban (PLB) is expressed in slow-twitch skeletal, cardiac, and smooth muscles. Several studies have indicated that it is an important regulator of…”
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Ectopic Expression of Phospholamban in Fast-Twitch Skeletal Muscle Alters Sarcoplasmic Reticulum Ca2+ Transport and Muscle Relaxation by Slack, Jay P., Grupp, Ingrid L., Ferguson, Donald G., Rosenthal, Nadia, Kranias, Evangelia G.

“…There are three isoforms of the sarcoplasmic reticulum Ca2+-ATPase; they are known as SERCA1, SERCA2, and SERCA3. Phospholamban is present in tissues that…”
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Sarco/Endoplasmic Reticulum Ca.sup.2+-ATPases by Iguchi, Naoko, Ohkuri, Tadahiro, Slack, Jay P, Zhong, Ping, Huang, Liquan

“…The sense of taste is important for providing animals with valuable information about the qualities of food, such as nutritional or harmful nature. Mammals,…”
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