Search Results - "Slack, F"

Evidence for early life in Earth’s oldest hydrothermal vent precipitates by Dodd, Matthew S., Papineau, Dominic, Grenne, Tor, Slack, John F., Rittner, Martin, Pirajno, Franco, O’Neil, Jonathan, Little, Crispin T. S.

“…Although it is not known when or where life on Earth began, some of the earliest habitable environments may have been submarine-hydrothermal vents. Here we…”
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Junk DNA and the long non-coding RNA twist in cancer genetics by Ling, H, Vincent, K, Pichler, M, Fodde, R, Berindan-Neagoe, I, Slack, F J, Calin, G A

“…The central dogma of molecular biology states that the flow of genetic information moves from DNA to RNA to protein. However, in the last decade this dogma has…”
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Iron formation; the sedimentary product of a complex interplay among mantle, tectonic, oceanic, and biospheric processes by Bekker, Andrey, Slack, John F, Planavsky, Noah, Krapez, Bryan, Hofmann, Axel, Konhauser, Kurt O, Rouxel, Olivier J

“…Iron formations are economically important sedimentary rocks that are most common in Precambrian sedimentary successions. Although many aspects of their origin…”
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MicroRNAs as potential cancer therapeutics by Trang, P, Weidhaas, J B, Slack, F J

“…MicroRNAs (miRNAs) have been shown to have an important role in various cellular processes, such as apoptosis, differentiation and development. Recent studies…”
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The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells by Kato, M, Paranjape, T, Ullrich, R, Nallur, S, Gillespie, E, Keane, K, Esquela-Kerscher, A, Weidhaas, J B, Slack, F J

“…MicroRNAs (miRNAs) are important regulators of cell fate determination and homeostasis. Expression of these small RNA genes is tightly regulated during…”
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A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer by Kasinski, A L, Kelnar, K, Stahlhut, C, Orellana, E, Zhao, J, Shimer, E, Dysart, S, Chen, X, Bader, A G, Slack, F J

“…Targeted cancer therapies, although often effective, have limited utility owing to preexisting primary or acquired secondary resistance. Consequently, agents…”
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Regression of murine lung tumors by the let-7 microRNA by Trang, P, Medina, P P, Wiggins, J F, Ruffino, L, Kelnar, K, Omotola, M, Homer, R, Brown, D, Bader, A G, Weidhaas, J B, Slack, F J

“…MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human…”
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MicroRNAs: tools for cancer diagnostics by Paranjape, T, Slack, F J, Weidhaas, J B

“…Recently, a novel class of global gene regulators called microRNAs (miRNAs), were identified in both plants and animals. MiRNAs can reduce protein levels of…”
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Strata-bound Fe-Co-Cu-Au-Bi-Y-REE deposits of the Idaho cobalt belt; multistage hydrothermal mineralization in a magmatic-related iron oxide copper-gold system by Slack, John F

“…Mineralogical and geochemical studies of strata-bound Fe-Co-Cu-Au-Bi-Y-rare-earth element (REE) deposits of the Idaho cobalt belt in east-central Idaho provide…”
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MUC1 inhibition leads to decrease in PD-L1 levels via upregulation of miRNAs by Pyzer, A R, Stroopinsky, D, Rosenblatt, J, Anastasiadou, E, Rajabi, H, Washington, A, Tagde, A, Chu, J-H, Coll, M, Jiao, A L, Tsai, L T, Tenen, D E, Cole, L, Palmer, K, Ephraim, A, Leaf, R K, Nahas, M, Apel, A, Bar-Natan, M, Jain, S, McMasters, M, Mendez, L, Arnason, J, Raby, B A, Slack, F, Kufe, D, Avigan, D

“…The PD-L1/PD-1 pathway is a critical component of the immunosuppressive tumor microenvironment in acute myeloid leukemia (AML), but little is known about its…”
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Hydrothermal, biogenic, and seawater components in metalliferous black shales of the Brooks Range, Alaska; synsedimentary metal enrichment in a carbonate ramp setting by Slack, John F, Selby, David, Dumoulin, Julie A

“…Trace element and Os isotope data for Lisburne Group metalliferous black shales of Middle Mississippian (early Chesterian) age in the Brooks Range of northern…”
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The hyper-enrichment of V and Zn in black shales of the Late Devonian-Early Mississippian Bakken Formation (USA) by Scott, Clint, Slack, John F., Kelley, Karen D.

“…Black shales of the Late Devonian to Early Mississippian Bakken Formation are characterized by high concentrations of organic carbon and the hyper-enrichment…”
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cel-mir-237 and its homologue, hsa-miR-125b, modulate the cellular response to ionizing radiation by Metheetrairut, C, Adams, B D, Nallur, S, Weidhaas, J B, Slack, F J

“…Elucidating the mechanisms involved in sensitizing radioresistant tumors to ionizing radiation (IR) treatments while minimizing injury to surrounding normal…”
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Targeted resequencing of the microRNAome and 3′UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer by Chen, X, Paranjape, T, Stahlhut, C, McVeigh, T, Keane, F, Nallur, S, Miller, N, Kerin, M, Deng, Y, Yao, X, Zhao, H, Weidhaas, J B, Slack, F J

“…Ovarian cancer is a major cause of cancer deaths, yet there have been few known genetic risk factors identified, the best known of which are disruptions in…”
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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans by Ruvkun, Gary, Reinhart, Brenda J, Slack, Frank J, Basson, Michael, Pasquinelli, Amy E, Bettinger, Jill C, Rougvie, Ann E, Horvitz, H. Robert

“…The C. elegans heterochronic gene pathway consists of a cascade of regulatory genes that are temporally controlled to specify the timing of developmental…”
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U-Pb, Re-Os, and Ar/Ar geochronology of rare earth element (REE)-rich breccia pipes and associated host rocks from the Mesoproterozoic Pea Ridge Fe-REE-Au deposit, St. Francois Mountains, Missouri by Aleinikoff, J. N, Selby, D, Slack, John F, Day, W. C, Pillers, R. M, Cosca, M. A, Seeger, Cheryl M, Fanning, C. M, Samson, I. M

“…Rare earth element (REE)-rich breccia pipes (600,000 t @12% rare earth oxides) are preserved along the margins of the 136-million metric ton (Mt) Pea Ridge…”
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Geochemistry of host rocks in the Howards Pass district, Yukon-Northwest Territories, Canada: implications for sedimentary environments of Zn-Pb and phosphate mineralization by Slack, John F ., Falck, Hendrik, Kelley, Karen D., Xue, Gabriel G.

“…Detailed lithogeochemical data are reported here on early Paleozoic sedimentary rocks that host the large Howards Pass stratiform Zn-Pb deposits in…”
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Adults with FPIES may face delayed diagnoses by Hua, Alexandra, Slack, Ian F., O’Shea, Kelly, Schuler, Charles F.

“…Food protein–induced enterocolitis (FPIES) is a non–IgE-mediated food allergy that is becoming increasingly recognized in adults. The time between age at…”
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Dyspnoea with progressive “idiopathic” pulmonary fibrosis by Puri, Chahat, Harish, Vignesh, Rhee, Kyunghoon, Slack, Donald F.

“…Telomeres are repetitive nucleotide sequences that prevent chromosomal shortening in cell replication. Short telomeres have been implicated in the pathogenesis…”
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A KRAS variant is a biomarker of poor outcome, platinum chemotherapy resistance and a potential target for therapy in ovarian cancer by Ratner, E S, Keane, F K, Lindner, R, Tassi, R A, Paranjape, T, Glasgow, M, Nallur, S, Deng, Y, Lu, L, Steele, L, Sand, S, Muller, R-U, Bignotti, E, Bellone, S, Boeke, M, Yao, X, Pecorelli, S, Ravaggi, A, Katsaros, D, Zelterman, D, Cristea, M C, Yu, H, Rutherford, T J, Weitzel, J N, Neuhausen, S L, Schwartz, P E, Slack, F J, Santin, A D, Weidhaas, J B

“…Germline variants in the 3′ untranslated region (3′UTR) of cancer genes disrupting microRNA (miRNA) regulation have recently been associated with cancer risk…”
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