Search Results - "Slöetjes, Annet W."

Induction of Canonical Wnt Signaling by the Alarmins S100A8/A9 in Murine Knee Joints: Implications for Osteoarthritis by van den Bosch, Martijn H., Blom, Arjen B., Schelbergen, Rik F. P., Vogl, Thomas, Roth, Johannes P., Slöetjes, Annet W., van den Berg, Wim B., van der Kraan, Peter M., van Lent, Peter L. E. M.

“…Objective Both alarmins S100A8/A9 and canonical Wnt signaling have been found to play active roles in the development of experimental osteoarthritis (OA)…”
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IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology by van Dalen, Stephanie C M, Blom, Arjen B, Walgreen, Birgitte, Slöetjes, Annet W, Helsen, Monique M A, Geven, Edwin J W, Ter Huurne, Menno, Vogl, Thomas, Roth, Johannes, van de Loo, Fons A J, Koenders, Marije I, Casteilla, Louis, van der Kraan, Peter M, van den Bosch, Martijn H J, van Lent, Peter L E M

“…Injection of adipose-derived mesenchymal stromal cells (ASCs) into murine knee joints after induction of inflammatory collagenase-induced osteoarthritis (CiOA)…”
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Nox2 Deficiency Reduces Cartilage Damage and Ectopic Bone Formation in an Experimental Model for Osteoarthritis by Kruisbergen, Nik N. L., Di Ceglie, Irene, van Gemert, Yvonne, Walgreen, Birgitte, Helsen, Monique M. A., Slöetjes, Annet W., Koenders, Marije I., van de Loo, Fons A. J., Roth, Johannes, Vogl, Thomas, van der Kraan, Peter M., Blom, Arjen B., van Lent, Peter L. E. M., van den Bosch, Martijn H. J.

“…Osteoarthritis (OA) is a destructive disease of the joint with age and obesity being its most important risk factors. Around 50% of OA patients suffer from…”
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Induction of Canonical Wnt Signaling by Synovial Overexpression of Selected Wnts Leads to Protease Activity and Early Osteoarthritis-Like Cartilage Damage by van den Bosch, Martijn H, Blom, Arjen B, Sloetjes, Annet W, Koenders, Marije I, van de Loo, Fons A, van den Berg, Wim B, van Lent, Peter L, van der Kraan, Peter M

“…Proteins from the Wnt signaling pathway are very important for joint development. Curiously, osteoarthritis (OA) is thought to be a recapitulation of…”
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S100A8 enhances osteoclastic bone resorption in vitro through activation of Toll‐like receptor 4: Implications for bone destruction in murine antigen‐induced arthritis by Grevers, Lilyanne C., de Vries, Teun J., Vogl, Thomas, Abdollahi‐Roodsaz, Shahla, Sloetjes, Annet W., Leenen, Pieter J. M., Roth, Johannes, Everts, Vincent, van den Berg, Wim B., van Lent, Peter L. E. M.

“…Objective Rheumatoid arthritis, which is associated with elevated levels of S100A8 and S100A9, is characterized by severe bone erosions caused by enhanced…”
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Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis by Di Ceglie, Irene, Ascone, Giuliana, Cremers, Niels A J, Sloetjes, Annet W, Walgreen, Birgitte, Vogl, Thomas, Roth, Johannes, Verbeek, J Sjef, van de Loo, Fons A J, Koenders, Marije I, van der Kraan, Peter M, Blom, Arjen B, van den Bosch, Martijn H J, van Lent, Peter L E M

“…Osteoclast-mediated bone erosion is a central feature of rheumatoid arthritis (RA). Immune complexes, present in a large percentage of patients, bind to Fcγ…”
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S100A8/A9 drives monocytes towards M2-like macrophage differentiation and associates with M2-like macrophages in osteoarthritic synovium by van Kooten, Nienke J T, Blom, Arjen B, Teunissen van Manen, Iris J, Theeuwes, Wessel F, Roth, Johannes, Gorris, Mark A J, Walgreen, Birgitte, Sloetjes, Annet W, Helsen, Monique M, Vitters, Elly L, van Lent, Peter L E M, Koëter, Sander, van der Kraan, Peter M, Vogl, Thomas, van den Bosch, Martijn H J

“…Macrophages are key orchestrators of the osteoarthritis (OA)-associated inflammatory response. Macrophage phenotype is dependent on environmental cues like the…”
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S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis by Geven, Edwin J W, van den Bosch, Martijn H J, Di Ceglie, Irene, Ascone, Giuliana, Abdollahi-Roodsaz, Shahla, Sloetjes, Annet W, Hermann, Sven, Schäfers, Michael, van de Loo, Fons A J, van der Kraan, Peter M, Koenders, Marije I, Foell, Dirk, Roth, Johannes, Vogl, Thomas, van Lent, Peter L E M

“…Seronegative joint diseases are characterized by a lack of well-defined biomarkers since autoantibodies are not elevated. Calprotectin (S100A8/A9) is a…”
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High LDL-C levels attenuate onset of inflammation and cartilage destruction in antigen-induced arthritis by Ascone, Giuliana, Di Ceglie, Irene, van den Bosch, Martijn H J, Kruisbergen, Nik N L, Walgreen, Birgitte, Sloetjes, Annet W, Lindhout, Ernst, Joosten, Leo A B, van de Loo, Fons A J, Koenders, Marije I, van der Kraan, Peter M, Blom, Arjen B, van Lent, Peter L E M

“…In this study, we used hypercholesterolaemic apolipoprotein E-deficient (Apoe-/-) mice to investigate LDL/oxLDL effect on synovial inflammation and cartilage…”
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Hematopoietic Malignancies Demonstrate Loss-of-Function Mutations ofBAX by Meijerink, Jules P.P., Mensink, Ewald J.B.M., Wang, Kun, Sedlak, Thomas W., Slöetjes, Annet W., de Witte, Theo, Waksman, Gabriel, Korsmeyer, Stanley J.

“…The BCL-2 gene family regulates the susceptibility to apoptotic cell death in many cell types during embryonic development and normal tissue homeostasis…”
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Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints by Van Der Voort, Robbert, Van Lieshout, Antoine W. T., Toonen, Liza W. J., Slöetjes, Annet W., Van Den Berg, Wim B., Figdor, Carl G., Radstake, Timothy R. D. J., Adema, Gosse J.

“…Objective Directional migration of leukocytes is orchestrated by the regulated expression of chemokine receptors and their ligands. The receptor CXCR6 is…”
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Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation by Nabbe, Karin C A M, van Lent, Peter L E M, Holthuysen, Astrid E M, Sloëtjes, Annet W, Koch, Alisa E, Radstake, Timothy R D J, van den Berg, Wim B

“…During immune-complex-mediated arthritis (ICA), severe cartilage destruction is mediated by Fcgamma receptors (FcgammaRs) (mainly FcgammaRI), cytokines (e.g…”
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Selectively induced death of macrophages in the synovial lining of murine knee joints using 10B-liposomes and boron neutron capture synovectomy by van Lent, Peter L. E. M., Krijger, Gerard C., Hofkens, Wouter, Nievaart, Victor A., Sloetjes, Annet W., Moss, Ray L., Koning, Gerben A., van den Berg, Wim B.

“…Objective: To investigate whether macrophages in the synovial lining can be selectively eliminated by local administration of an improved boron-10 (10B)…”
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Hematopoietic malignancies demonstrate loss-of-function mutations of BAX by MEIJERINK, J. R, MENSINK, E. J. B. M, KUN WANG, SEDLAK, T. W, SLÖETJES, A. W, DE WITTE, T, WAKSMAN, G, KORSMEYER, S. J

“…The BCL-2 gene family regulates the susceptibility to apoptotic cell death in many cell types during embryonic development and normal tissue homeostasis…”
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Selectively induced death of macrophages in the synovial lining of murine knee joints using 10 B-liposomes and boron neutron capture synovectomy by van Lent, Peter L. E. M., Krijger, Gerard C., Hofkens, Wouter, Nievaart, Victor A., Sloetjes, Annet W., Moss, Ray L., Koning, Gerben A., van den Berg, Wim B.

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Selectively induced death of macrophages in the synovial lining of murine knee joints using 10B-liposomes and boron neutron capture synovectomy by van Lent, Peter L E M, Krijger, Gerard C, Hofkens, Wouter, Nievaart, Victor A, Sloetjes, Annet W, Moss, Ray L, Koning, Gerben A, van den Berg, Wim B

“…To investigate whether macrophages in the synovial lining can be selectively eliminated by local administration of an improved boron-10 ((10)B) containing…”
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Increased expression of Fcγ receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor α and matrix metalloproteinase by Blom, Arjen B., Radstake, Timothy R. D. J., Holthuysen, Astrid E. M., Slöetjes, Annet W., Pesman, Gerard J., Sweep, Fred G. J., van de Loo, Fons A. J., Joosten, L. A. B., Barrera, Pilar, van Lent, Peter L. E. M., van den Berg, Wim B.

“…Objective To evaluate Fcγ receptor (FcγR) expression on synovial macrophages from rheumatoid arthritis (RA) patients and to determine whether this expression…”
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Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase by Blom, Arjen B, Radstake, Timothy R D J, Holthuysen, Astrid E M, Slöetjes, Annet W, Pesman, Gerard J, Sweep, Fred G J, van de Loo, Fons A J, Joosten, L A B, Barrera, Pilar, van Lent, Peter L E M, van den Berg, Wim B

“…To evaluate Fcgamma receptor (FcgammaR) expression on synovial macrophages from rheumatoid arthritis (RA) patients and to determine whether this expression…”
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Increased expression of Fcγ receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor a and matrix metalloproteinase by BLOM, Arjen B, RADSTAKE, Timothy R. D. J, VAN DEN BERG, Wim B, HOLTHUYSEN, Astrid E. M, SLÖETJES, Annet W, PESMAN, Gerard J, SWEEP, Fred G. J, VAN DE LOO, Fons A. J, JOOSTEN, L. A. B, BARRERA, Pilar, VAN LENT, Peter L. E. M

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Different amplifying mechanisms of interleukin‐17 and interferon‐γ in Fcγ receptor–mediated cartilage destruction in murine immune complex–mediated arthritis by Grevers, Lilyanne C., van Lent, Peter L. E. M., Koenders, Marije I., Walgreen, Birgitte, Sloetjes, Annet W., Nimmerjahn, Falk, Sjef Verbeek, J., van den Berg, Wim B.

“…Objective Previously, we reported that interferon‐γ (IFNγ) aggravates cartilage destruction in immune complex (IC)–mediated arthritis via up‐regulation of…”
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