Search Results - "Skytte, Dorthe Mondrup"

A Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells by Christensen, S Brøgger, Skytte, Dorthe Mondrup, Denmeade, Samuel R, Dionne, Craig, Møller, Jesper Vuust, Nissen, Poul, Isaacs, John T

“…Available chemotherapeutics take advantage of the fast proliferation of cancer cells. Consequently slow growth makes androgen refractory prostate cancer…”
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Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase by Skytte, Dorthe Mondrup, Møller, Jesper Vuust, Liu, Huizhen, Nielsen, Helle Østergren, Svenningsen, Louise Elsa, Jensen, Christina Mernøe, Olsen, Carl Erik, Christensen, Søren Brøgger

“…Removal of each of the acyl groups of thapsigargin at O-3, O-8 and O-10 significant reduces the affinity of the inhibitors to the SERCA1a pump. Replacement of…”
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Structure and Absolute Configuration of Nyasol and Hinokiresinol via Synthesis and Vibrational Circular Dichroism Spectroscopy by Lassen, Peter R, Skytte, Dorthe Mondrup, Hemmingsen, Lars, Nielsen, Simon Feldbæk, Freedman, Teresa B, Nafie, Laurence A, Christensen, S. Brøgger

“…The absolute configuration of the norlignan (+)-nyasol was determined to be S by comparison of the experimental vibrational circular dichroism data with…”
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Antimalarial and Antiplasmodial Activities of Norneolignans. Syntheses and SAR by Skytte, Dorthe Mondrup, Nielsen, Simon Feldbæk, Chen, Ming, Zhai, Lin, Olsen, Carl Erik, Christensen, Søren Brøgger

“…A systematic change of the substituents and side chain of the norneolignan hinokiresinol afforded a 10 fold improvement of the IC50 value toward inhibition of…”
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Carroll rearrangement to construct the norneolignan skeleton by Skytte, Dorthe Mondrup, Rasmussen, Hasse Bonde, Christensen, Søren Brøgger

“…A three-step synthesis of the norneolignan skeleton involving the Carroll rearrangement as the key step has been developed and used for synthesis of the…”
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