Search Results - "Skupa, Sydney A"

Defining the Role of the Gut Microbiome in the Pathogenesis and Treatment of Lymphoid Malignancies by Upadhyay Banskota, Shristi, Skupa, Sydney A, El-Gamal, Dalia, D'Angelo, Christopher R

“…The gut microbiome is increasingly being recognized as an important immunologic environment, with direct links to the host immune system. The scale of the gut…”
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A Novel Triple-Action Inhibitor Targeting B-Cell Receptor Signaling and BRD4 Demonstrates Preclinical Activity in Chronic Lymphocytic Leukemia by Smith, Audrey L, Eiken, Alexandria P, Skupa, Sydney A, Moore, Dalia Y, Umeta, Lelisse T, Smith, Lynette M, Lyden, Elizabeth R, D'Angelo, Christopher R, Kallam, Avyakta, Vose, Julie M, Kutateladze, Tatiana G, El-Gamal, Dalia

“…B-cell chronic lymphocytic leukemia (CLL) results from intrinsic genetic defects and complex microenvironment stimuli that fuel CLL cell growth through an…”
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The Novel Anti-Cancer Agent, SpiD3, Is Cytotoxic in CLL Cells Resistant to Ibrutinib or Venetoclax by Eiken, Alexandria P, Schmitz, Elizabeth, Drengler, Erin M, Smith, Audrey L, Skupa, Sydney A, Mohan, Kabhilan, Rana, Sandeep, Singh, Sarbjit, Mallareddy, Jayapal Reddy, Mathew, Grinu, Natarajan, Amarnath, El-Gamal, Dalia

“…B-cell receptor (BCR) signaling is a central driver in chronic lymphocytic leukemia (CLL), along with the activation of pro-survival pathways (e.g., NF-κB) and…”
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Targeted BET inhibition with OPN-51107 synergizes with venetoclax in chronic lymphocytic leukemia by Zablonski, Kevin G, Skupa, Sydney A, Eiken, Alexandria P, Sundaram, Suchitra, Mavis, Cory, Gu, Juan Jenny, Torka, Pallawi, Ghione, Paola, El-Gamal, Dalia, Hernandez-Ilizaliturri, Francisco J

“…Chronic lymphocytic leukemia (CLL) remains incurable and its ability to acquire resistance to front-line therapeutics has proved challenging. Bromodomain and…”
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Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects by Eiken, Alexandria P, Smith, Audrey L, Skupa, Sydney A, Schmitz, Elizabeth, Rana, Sandeep, Singh, Sarbjit, Kumar, Siddhartha, Mallareddy, Jayapal Reddy, de Cubas, Aguirre A, Krishna, Akshay, Kalluchi, Achyuth, Rowley, M Jordan, D'Angelo, Christopher R, Lunning, Matthew A, Bociek, R Gregory, Vose, Julie M, Natarajan, Amarnath, El-Gamal, Dalia

“…Chronic lymphocytic leukemia (CLL) cell survival and growth is fueled by the induction of B-cell receptor (BCR) signaling within the tumor microenvironment…”
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BET inhibition reforms the immune microenvironment and alleviates T cell dysfunction in chronic lymphocytic leukemia by Smith, Audrey L, Skupa, Sydney A, Eiken, Alexandria P, Reznicek, Timothy E, Schmitz, Elizabeth, Williams, Nolan, Moore, Dalia Y, D'Angelo, Christopher R, Kallam, Avyakta, Lunning, Matthew A, Bociek, R Gregory, Vose, Julie M, Mohamed, Eslam, Mahr, Anna R, Denton, Paul W, Powell, Ben, Bollag, Gideon, Rowley, M Jordan, El-Gamal, Dalia

“…Redundant tumor microenvironment (TME) immunosuppressive mechanisms and epigenetic maintenance of terminal T cell exhaustion greatly hinder functional…”
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Comparison of Dietary Intake and Dietary Inflammatory Index in Patients with Chronic Lymphocytic Leukemia By Treatment Status to Cohabitating Controls by D'Angelo, Christopher R, Rasmussen, Heather, Yu, Fang, Skupa, Sydney A, El-Gamal, Dalia

“…Chronic lymphocytic leukemia (CLL) is an incurable disease with a varied presentation ranging from indolent and asymptomatic to morbid and life-limiting. As…”
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A Novel Spirocyclic Dimer (SpiD3) Resensitizes CLL Cells to Venetoclax by Eiken, Alexandria P, Skupa, Sydney A, Brown, Neecole, Smith, Audrey L, Singh, Sarbjit, Rana, Sandeep, Natarajan, Amarnath, ElGamal, Dalia

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Progressive Gut Microbiome Dysbiosis Is Associated with Chronic Lymphocytic Leukemia Pathogenesis and Development in the Eµ-TCL1 Mouse Model by Skupa, Sydney A, Smith, Audrey L, Eiken, Alexandria P, Schmitz, Elizabeth A, Cooper, Kathryn M, D'Angelo, Christopher R, El-Gamal, Dalia

“…Introduction: The gut microbiome is home to a community of microorganisms such as bacteria, fungi, viruses, archaea, and protozoa. Maintaining a balance…”
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BET Inhibition As a Targeted Epigenetic Approach to Reverse T Cell Dysfunction in Chronic Lymphocytic Leukemia by Smith, Audrey L, Eiken, Alexandria P, Skupa, Sydney A, Moore, Dalia Y, Kallam, Avyakta, D'Angelo, Christopher, Bociek, Gregory R, Lunning, Matthew A., Vose, Julie M., Powell, Ben, Bollag, Gideon, ElGamal, Dalia

“…Introduction: Chronic Lymphocytic Leukemia (CLL) is characterized by the clonal expansion of mature CD19+/CD5+ lymphocytes in the peripheral blood and…”
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Abstract 6396: BET inhibition alleviates T-cell dysfunction in chronic lymphocytic leukemia by Smith, Audrey L., Eiken, Alexandria P., Skupa, Sydney A., D'Angelo, Christopher R., Kallam, Avyakta, Lunning, Matthew A., Bociek, Gregory, Vose, Julie M., Powell, Ben, Bollag, Gideon, El-Gamal, Dalia

“…Abstract Background: The chronic lymphocytic leukemia (CLL) tumor microenvironment (TME) is laden with hyporesponsive T-cells that permit disease persistence…”
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