Search Results - "Skulnick, Harvey I"

Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class by Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Aristoff, Paul A, Johnson, Paul D, Skulnick, Harvey I, Dolak, Lester A, Seest, Eric P, Tomich, Paul K, Bohanon, Michael J, Horng, Miao-Miao, Lynn, Janet C, Chong, Kong-Teck, Hinshaw, Roger R, Watenpaugh, Keith D, Janakiraman, Musiri N, Thaisrivongs, Suvit

“…A broad screening program previously identified phenprocoumon (1) as a small molecule template for inhibition of HIV protease. Subsequent modification of this…”
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General, efficient, one-step synthesis of .beta.-keto esters by Wierenga, Wendell, Skulnick, Harvey I

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Pyrimidinones. 3. N-Substituted 6-phenylpyrimidinones and pyrimidinediones with diuretic/hypotensive and antiinflammatory activity by Skulnick, Harvey I, Ludens, James H, Wendling, Michael G, Glenn, E. Myles, Rohloff, Norman A, Smith, Robert J, Wierenga, Wendell

“…In an extensive analysis of the antiviral and interferon-induction structure-activity relationship of 6-arylpyrimidinones we found that modifications at…”
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Pyrimidinones. 1. 2-Amino-5-halo-6-aryl-4(3H)-pyrimidinones. Interferon-inducing antiviral agents by Skulnick, Harvey I, Weed, Sheldon D, Eidson, Emerson E, Renis, Harold E, Stringfellow, Dale A, Wierenga, Wendell

“…Interferon induction and antiviral activity was discovered with 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone. An analogue study incorporating a series of…”
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5-Substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral- and interferon-inducing agents by Wierenga, Wendell, Skulnick, Harvey I, Stringfellow, Dale A, Weed, Sheldon D, Renis, Harold E, Eidson, Emerson E

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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors:  The Sulfonamide-Substituted Cyclooctylpyranones by Skulnick, Harvey I, Johnson, Paul D, Aristoff, Paul A, Morris, Jeanette K, Lovasz, Kristine D, Howe, W. Jeffrey, Watenpaugh, Keith D, Janakiraman, Musiri N, Anderson, David J, Reischer, Robert J, Schwartz, Theresa M, Banitt, Lee S, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Dolak, Lester A, Seest, Eric P, Schwende, Francis J, Rush, Bob D, Howard, Gina M, Toth, Lisa N, Wilkinson, Karen R, Kakuk, Thomas J, Johnson, Carol W, Cole, Serena L, Zaya, Renee M, Zipp, Gail L, Possert, Peggy L, Dalga, Robert J, Zhong, Wei-Zhu, Williams, Marta G, Romines, Karen R

“…Recently, cyclooctylpyranone derivatives with m-carboxamide substituents (e.g. 2c) were identified as potent, nonpeptidic HIV protease inhibitors, but these…”
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Structure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease Inhibitors by Skulnick, Harvey I, Johnson, Paul D, Howe, W. Jeffrey, Tomich, Paul K, Chong, Kong-Teck, Watenpaugh, Keith D, Janakiraman, Musiri N, Dolak, Lester A, McGrath, James P

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Regioselective Synthesis of N-1 and N-2 Substituted Pyrimidinones Employing a Novel 1,3-Oxazine Preparation by Wierenga, Wendell, I. Skulnick, Harvey

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K252a, KT5720, KT5926, and U98017 support paclitaxel (taxol)-dependent cells and synergize with paclitaxel by ABRAHAM, I, WOLF, C. L, SAMPTON, K. E, LABORDE, A. L, SHELLY, J. A, ARISTOFF, P. A, SKULNICK, H. I

“…We have used paclitaxel-dependent Tax 2-4 cells to screen for compounds that have paclitaxel-like functional activity. The indolocarbazole serine/threonine…”
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Synthesis and pharmacological evaluation of sulfone substituted HIV protease inhibitors by Schwartz, Theresa M., Bundy, Gordon L., Strohbach, Joseph W., Thaisrivongs, Suvit, Johnson, Paul D., Skulnick, Harvey I., Tomich, Paul K., Lynn, Janet C., Chong, Kong Teck, Hinshaw, Roger R., Raub, Thomas J., Padbury, Guy E., Toth, Lisa N.

“…The sulfonamide substituted pyranones ( 1) have recently been shown to be potent HIV protease inhibitors. We prepared a series of sulfone substituted analogs…”
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Synthesis of 2-Amino-6-phenyl-4(3H)-pyrimidinone-1-oxide by Wierenga, Wendell, I. Skulnick, Harvey, L. Dow, Robert, G. Chidester, Constance

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Antitumor activity of pyrimidinones, a class of small-molecule biological response modifiers by Li, L H, Wallace, T L, Wierenga, W, Skulnick, H I, DeKoning, T F

“…This study was undertaken in an attempt to evaluate the structure-activity relationship of pyrimidinones. Of 20 pyrimidinones tested, only those with a…”
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