Search Results - "Skulachev, V.P"

Mechanisms of nephroprotective effect of mitochondria-targeted antioxidants under rhabdomyolysis and ischemia/reperfusion by Plotnikov, E.Y., Chupyrkina, A.A., Jankauskas, S.S., Pevzner, I.B., Silachev, D.N., Skulachev, V.P., Zorov, D.B.

“…Oxidative stress-related renal pathologies apparently include rhabdomyolysis and ischemia/reperfusion phenomenon. These two pathologies were chosen for study…”
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Effect of oxidative stress on dynamics of mitochondrial reticulum by Pletjushkina, O.Yu, Lyamzaev, K.G., Popova, E.N., Nepryakhina, O.K., Ivanova, O.Yu, Domnina, L.V., Chernyak, B.V., Skulachev, V.P.

“…Fission of the mitochondrial reticulum (the thread–grain transition) and following gathering of mitochondria in the perinuclear area are induced by oxidative…”
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Interrelations of mitochondrial fragmentation and cell death under ischemia/reoxygenation and UV-irradiation: Protective effects of SkQ1, lithium ions and insulin by Plotnikov, E.Y., Vasileva, A.K., Arkhangelskaya, A.A., Pevzner, I.B., Skulachev, V.P., Zorov, D.B.

“…Mitochondria-targeted antioxidant 10-(6-plastoquinonyl)decyltriphenyl-phosphonium (SkQ1) as well as insulin and the inhibitor of glycogen-synthase kinase, Li +…”
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Cytochrome c, an ideal antioxidant by Pereverzev, M O, Vygodina, T V, Konstantinov, A A, Skulachev, V P

“…Generation of DeltaPsi (membrane potential) by cytochrome oxidase proteoliposomes oxidizing superoxide-reduced cytochrome c has been demonstrated. XO+HX…”
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Phenoptosis as a Phenomenon Widespread among Many Groups of Living Organisms Including Mammals by Skulachev, V.P

“…Author congratulates David Gems and co-authors on a brilliant discovery--direct proof of acute phenoptosis in the nematode--but argues that the authors…”
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Reactive oxygen species, mitochondria, apoptosis and aging by Papa, S, Skulachev, V.P

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Inhibition of the alternative oxidase stimulates H2O2 production in plant mitochondria by Popov, V.N, Simonian, R.A, Skulachev, V.P, Starkov, A.A

“…The hypothesis that a non‐coupled alternative oxidase of plant mitochondria operates as an antioxygen defence mechanism [Purvis, A.C. and Shewfelt, R.L.,…”
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Marginal blebbing during the early stages of TNF-induced apoptosis indicates alteration in actomyosin contractility by Domnina, L.V, Ivanova, O.Y, Pletjushkina, O.Y, Fetisova, E.K, Chernyak, B.V, Skulachev, V.P, Vasiliev, J.M

“…Dynamics of alterations of cell surface topography during TNF-induced apoptosis of HeLa cells was examined by phase-contrast videomicroscopy and…”
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Interruption of the organismal senescence program by Skulachev, V.P.

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What is “phenoptosis” and how to fight it? by Skulachev, V. P.

“…Phenoptosis is the death of an organism programmed by its genome. Numerous examples of phenoptosis are described in prokaryotes, unicellular eukaryotes, and…”
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Programmed aging of mammals: Proof of concept and prospects of biochemical approaches for anti-aging therapy by Skulachev, M. V., Skulachev, V. P.

“…(i) In 2015-2017 we compared possible reasons for longevity of two mammalian highly social species, i.e. naked mole rats and humans. We proposed that in both…”
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Membrane potential generation coupled to oxidation of external NADH in liver mitochondria by Bodrova, M.E., Dedukhova, V.I., Mokhova, E.N., Skulachev, V.P.

“…Oxidation of added NADH by rat liver mitochondria has been studied. It is found that exogenous NADH, when oxidized by rat liver mitochondria in sucrose…”
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Neotenic Traits in Heterocephalus glaber and Homo sapiens by Popov, N. A., Skulachev, V. P.

“…The data on the neoteny (prolongation of youth and retardation of aging) in naked mole rat ( Heterocephalus glaber ) and Homo sapiens are summarized…”
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Proteorhodopsin from Dokdonia sp. PRO95 is a light-driven [Na.sup.+]-pump by Bertsova, Y.V, Bogachev, A.V, Skulachev, V.P

“…The gene encoding proteorhodopsin AEX55013 from Dokdonia sp. PRO95 was cloned and expressed in Escherichia coli cells. Illumination of the…”
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New data on programmed aging — slow phenoptosis by Skulachev, M. V., Skulachev, V. P.

“…This review summarizes the latest data on biochemistry and physiology of living organisms. These data suggest that aging, i.e. coordinated age-dependent…”
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Uncoupling and toxic action of alkyltriphenylphosphonium cations on mitochondria and the bacterium Bacillus subtilis as a function of alkyl chain length by Khailova, L. S., Nazarov, P. A., Sumbatyan, N. V., Korshunova, G. A., Rokitskaya, T. I., Dedukhova, V. I., Antonenko, Yu. N., Skulachev, V. P.

“…A series of permeating cations based on alkyl derivatives of triphenylphosphonium (C n -TPP + ) containing linear hydrocarbon chains (butyl, octyl, decyl, and…”
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Is It Possible to Prove the Existence of an Aging Program by Quantitative Analysis of Mortality Dynamics? by Shilovsky, G.A, Putyatina, T.S, Lysenkov, S.N, Ashapkin, V.V, Luchkina, O.S, Markov, A.V, Skulachev, V.P

“…Accumulation of various types of lesions in the course of aging increases an organism's vulnerability and results in a monotonous elevation of mortality rate,…”
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Mitochondrial genome and longevity by Zinovkin, R. A., Skulachev, M. V., Skulachev, V. P.

“…The mitochondrial genome provides not only respiratory chain function, but it also ensures the impact of mitochondria on nearly all crucial metabolic…”
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Study of age-dependent structural and functional changes of mitochondria in skeletal muscles and heart of naked mole rats (Heterocephalus glaber) by Holtze, S., Eldarov, C. M., Vays, V. B., Vangeli, I. M., Vysokikh, M. Yu, Bakeeva, L. E., Skulachev, V. P., Hildebrandt, T. B.

“…Morphometric analysis of mitochondria in skeletal muscles and heart of 6- and 60-month-old naked mole rats ( Heterocephalus glaber ) revealed a significant…”
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Ants as Object of Gerontological Research by Shilovsky, G. A., Putyatina, T. S., Ashapkin, V. V., Rozina, A. A., Lyubetsky, V. A., Minina, E. P., Bychkovskaia, I. B., Markov, A. V., Skulachev, V. P.

“…Social insects with identical genotype that form castes with radically different lifespans are a promising model system for studying the mechanisms underlying…”
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