Search Results - "Skulachev, V P"

Bioenergetic aspects of apoptosis, necrosis and mitoptosis by Skulachev, V P

“…In this review I summarize interrelations between bioenergetic processes and such programmed death phenomena as cell suicide (apoptosis and necrosis) and…”
Get full text

A biochemical approach to the problem of aging: "megaproject" on membrane-penetrating ions. The first results and prospects by Skulachev, V P

“…Antioxidants specifically addressed to mitochondria have been studied for their ability to decelerate aging of organisms. For this purpose, a project has been…”
Get full text

Mitochondrion-targeted antioxidant SkQ1 prevents rapid animal death caused by highly diverse shocks by Skulachev, V. P., Vyssokikh, M. Yu, Chernyak, B. V., Averina, O. A., Andreev-Andrievskiy, A. A., Zinovkin, R. A., Lyamzaev, K. G., Marey, M. V., Egorov, M. V., Frolova, O. J., Zorov, D. B., Skulachev, M. V., Sadovnichii, V. A.

“…The response to stress involves the activation of pathways leading either to protection from the stress origin, eventually resulting in development of stress…”
Get full text

Functions of mitochondria: from intracellular power stations to mediators of a senescence program by Skulachev, V. P.

“… In 1950 s I started in science by showing that non-phosphorylating respiration is critical for survival of an animal at low temperature. Later, in the 1960 s…”
Get full text

Mitochondrial-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies by Skulachev, M V, Antonenko, Y N, Anisimov, V N, Chernyak, B V, Cherepanov, D A, Chistyakov, V A, Egorov, M V, Kolosova, N G, Korshunova, G A, Lyamzaev, K G, Plotnikov, E Y, Roginsky, V A, Savchenko, A Y, Severina, I I, Severin, F F, Shkurat, T P, Tashlitsky, V N, Shidlovsky, K M, Vyssokikh, M Y, Zamyatnin, Jr, A A, Zorov, D B, Skulachev, V P

“…Plastoquinone, a very effective electron carrier and antioxidant of chloroplasts, was conjugated with decyltriphenylphosphonium to obtain a cation easily…”
Get more information

New data on biochemical mechanism of programmed senescence of organisms and antioxidant defense of mitochondria by Skulachev, V. P

“…Much evidence has recently been reported suggesting that reactive oxygen species (ROS) produced in mitochondria play a crucial role in the programmed…”
Get full text

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and Age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke) by Bakeeva, L. E., Barskov, I. V., Egorov, M. V., Isaev, N. K., Kapelko, V. I., Kazachenko, A. V., Kirpatovsky, V. I., Kozlovsky, S. V., Lakomkin, V. L., Levina, S. B., Pisarenko, O. I., Plotnikov, E. Y., Saprunova, V. B., Serebryakova, L. I., Skulachev, M. V., Stelmashook, E. V., Studneva, I. M., Tskitishvili, O. V., Vasilyeva, A. K., Victorov, I. V., Zorov, D. B., Skulachev, V. P.

“…Effects of 10-(6′-plastoquinonyl) decyltriphenylphosphonium (SkQ1) and 10-(6′-plastoquinonyl) decylrhod-amine 19 (SkQR1) on rat models of H 2 O 2 - and…”
Get full text

Mild uncoupling of respiration and phosphorylation as a mechanism providing nephro- and neuroprotective effects of penetrating cations of the SkQ family by Plotnikov, E. Y., Silachev, D. N., Jankauskas, S. S., Rokitskaya, T. I., Chupyrkina, A. A., Pevzner, I. B., Zorova, L. D., Isaev, N. K., Antonenko, Y. N., Skulachev, V. P., Zorov, D. B.

“…It is generally accepted that mitochondrial production of reactive oxygen species is nonlinearly related to the value of the mitochondrial membrane potential…”
Get full text

Phenoptosis as a Phenomenon Widespread among Many Groups of Living Organisms Including Mammals (Commentary to the Paper by E. R. Galimov, J. N. Lohr, and D. Gems (2019) Biochemistry (Moscow), 84, 1433–1437) by Skulachev, V. P.

“…Author congratulates David Gems and co-authors on a brilliant discovery — direct proof of acute phenoptosis in the nematode — but argues that the authors…”
Get full text

Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss by Jankauskas, S. S., Plotnikov, E. Y., Morosanova, M. A., Pevzner, I. B., Zorova, L. D., Skulachev, V. P., Zorov, D. B.

“…The influence of the mitochondria-targeted antioxidant SkQR1 on gentamycin-induced nephrotoxicity and ototoxicity has been analyzed. SkQR1 reduces the death of…”
Get full text

Protective Effects of Mitochondria-Targeted Antioxidant SkQ in Aqueous and Lipid Membrane Environments by Antonenko, Y. N., Roginsky, V. A., Pashkovskaya, A. A., Rokitskaya, T. I., Kotova, E. A., Zaspa, A. A., Chernyak, B. V., Skulachev, V. P.

“…The antioxidant activity of mitochondria-targeted small molecules, SkQ1 and MitoQ (conjugates of a lipophilic decyltriphenylphosphonium cation with an…”
Get full text

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells by Agapova, L. S, Chernyak, B. V, Domnina, L. V, Dugina, V. B, Efimenko, A. Yu, Fetisova, E. K, Ivanova, O. Yu, Kalinina, N. I, Khromova, N. V, Kopnin, B. P, Kopnin, P. B, Korotetskaya, M. V, Lichinitser, M. R, Lukashev, A. L, Pletjushkina, O. Yu, Popova, E. N, Skulachev, M. V, Shagieva, G. S, Stepanova, E. V, Titova, E. V, Tkachuk, V. A, Vasiliev, J. M, Skulachev, V. P

“…It was proposed that increased level of mitochondrial reactive oxygen species (ROS), mediating execution of the aging program of an organism, could also be…”
Get full text

Phenoptosis: programmed death of an organism by Skulachev, V P

“…Programmed cell death (apoptosis) is well-established in many multicellular organisms. Apoptosis purifies a tissue from cells that became useless or even…”
Get more information

What is “phenoptosis” and how to fight it? by Skulachev, V. P.

“…Phenoptosis is the death of an organism programmed by its genome. Numerous examples of phenoptosis are described in prokaryotes, unicellular eukaryotes, and…”
Get full text

Programmed aging of mammals: Proof of concept and prospects of biochemical approaches for anti-aging therapy by Skulachev, M. V., Skulachev, V. P.

“…(i) In 2015-2017 we compared possible reasons for longevity of two mammalian highly social species, i.e. naked mole rats and humans. We proposed that in both…”
Get full text

Discovery of a photosynthesizing animal that can survive for months in a light-dependent manner by Skulachev, V. P

“…Recently M. E. Rumpho and coworkers (USA) established that the marine slug Elysia chlorotica, a gastropod mollusk that feeds on the eukaryotic filamentous…”
Get full text

Cytochrome c, an ideal antioxidant by Pereverzev, M O, Vygodina, T V, Konstantinov, A A, Skulachev, V P

“…Generation of DeltaPsi (membrane potential) by cytochrome oxidase proteoliposomes oxidizing superoxide-reduced cytochrome c has been demonstrated. XO+HX…”
Get more information

Neotenic Traits in Heterocephalus glaber and Homo sapiens by Popov, N. A., Skulachev, V. P.

“…The data on the neoteny (prolongation of youth and retardation of aging) in naked mole rat ( Heterocephalus glaber ) and Homo sapiens are summarized…”
Get full text

Aging is a specific biological function rather than the result of a disorder in complex living systems: biochemical evidence in support of Weismann's hypothesis by Skulachev, V P

“…A concept postulating that aging is a specific biological function that promotes the progressive evolution of sexually reproducing species is reviewed. Death…”
Get more information

Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation by Skulachev, Vladimir P.

“…Free fatty acids, natural uncouplers of oxidative phosphorylation, are shown to differ from artificial ones in that they fail to increase conductance of…”
Get full text