Search Results - "Skucha, Anna"

Roles of SETD2 in Leukemia-Transcription, DNA-Damage, and Beyond by Skucha, Anna, Ebner, Jessica, Grebien, Florian

“…The non-redundant histone methyltransferase SETD2 (SET domain containing 2; KMT3A) is responsible for tri-methylation of lysine 36 on histone H3 (H3K36me3)…”
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STAT3 regulated ARF expression suppresses prostate cancer metastasis by Pencik, Jan, Schlederer, Michaela, Gruber, Wolfgang, Unger, Christine, Walker, Steven M., Chalaris, Athena, Marié, Isabelle J., Hassler, Melanie R., Javaheri, Tahereh, Aksoy, Osman, Blayney, Jaine K., Prutsch, Nicole, Skucha, Anna, Herac, Merima, Krämer, Oliver H., Mazal, Peter, Grebien, Florian, Egger, Gerda, Poli, Valeria, Mikulits, Wolfgang, Eferl, Robert, Esterbauer, Harald, Kennedy, Richard, Fend, Falko, Scharpf, Marcus, Braun, Martin, Perner, Sven, Levy, David E., Malcolm, Tim, Turner, Suzanne D., Haitel, Andrea, Susani, Martin, Moazzami, Ali, Rose-John, Stefan, Aberger, Fritz, Merkel, Olaf, Moriggl, Richard, Culig, Zoran, Dolznig, Helmut, Kenner, Lukas

“…Prostate cancer (PCa) is the most prevalent cancer in men. Hyperactive STAT3 is thought to be oncogenic in PCa. However, targeting of the IL-6/STAT3 axis in…”
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General and MicroRNA-Mediated mRNA Degradation Occurs on Ribosome Complexes in Drosophila Cells by Antic, Sanja, Wolfinger, Michael T., Skucha, Anna, Hosiner, Stefanie, Dorner, Silke

“…The translation and degradation of mRNAs are two key steps in gene expression that are highly regulated and targeted by many factors, including microRNAs…”
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MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity by Skucha, Anna, Ebner, Jessica, Schmöllerl, Johannes, Roth, Mareike, Eder, Thomas, César-Razquin, Adrián, Stukalov, Alexey, Vittori, Sarah, Muhar, Matthias, Lu, Bin, Aichinger, Martin, Jude, Julian, Müller, André C., Győrffy, Balázs, Vakoc, Christopher R., Valent, Peter, Bennett, Keiryn L., Zuber, Johannes, Superti-Furga, Giulio, Grebien, Florian

“…MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL…”
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A kinase-independent role for CDK8 in BCR-ABL1+ leukemia by Menzl, Ingeborg, Zhang, Tinghu, Berger-Becvar, Angelika, Grausenburger, Reinhard, Heller, Gerwin, Prchal-Murphy, Michaela, Edlinger, Leo, Knab, Vanessa M., Uras, Iris Z., Grundschober, Eva, Bauer, Karin, Roth, Mareike, Skucha, Anna, Liu, Yao, Hatcher, John M., Liang, Yanke, Kwiatkowski, Nicholas P., Fux, Daniela, Hoelbl-Kovacic, Andrea, Kubicek, Stefan, Melo, Junia V., Valent, Peter, Weichhart, Thomas, Grebien, Florian, Zuber, Johannes, Gray, Nathanael S., Sexl, Veronika

“…Cyclin-dependent kinases (CDKs) are frequently deregulated in cancer and represent promising drug targets. We provide evidence that CDK8 has a key role in…”
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SETD2 in MLL-rearranged leukemia - a complex case by Skucha, Anna, Ebner, Jessica, Grebien, Florian

“…Oncogenic MLL-fusion proteins often hijack essential molecular mechanisms during leukemogenesis. The histone methyltransferase SETD2 was implicated in the…”
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Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia by Grebien, Florian, Vedadi, Masoud, Getlik, Matthäus, Giambruno, Roberto, Grover, Amit, Avellino, Roberto, Skucha, Anna, Vittori, Sarah, Kuznetsova, Ekaterina, Smil, David, Barsyte-Lovejoy, Dalia, Li, Fengling, Poda, Gennadiy, Schapira, Matthieu, Wu, Hong, Dong, Aiping, Senisterra, Guillermo, Stukalov, Alexey, Huber, Kilian V M, Schönegger, Andreas, Marcellus, Richard, Bilban, Martin, Bock, Christoph, Brown, Peter J, Zuber, Johannes, Bennett, Keiryn L, Al-awar, Rima, Delwel, Ruud, Nerlov, Claus, Arrowsmith, Cheryl H, Superti-Furga, Giulio

“…The p30 isoform of C/EBPα associated with leukemia interacts with WDR5, a component of the SET/MLL histone methyltransferase complex. A small molecule,…”
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EGF activates TTP expression by activation of ELK-1 and EGR-1 transcription factors by Florkowska, Magdalena, Tymoszuk, Piotr, Balwierz, Aleksandra, Skucha, Anna, Kochan, Jakub, Wawro, Mateusz, Stalinska, Krystyna, Kasza, Aneta

“…Tristetraprolin (TTP) is a key mediator of processes such as inflammation resolution, the inhibition of autoimmunity and in cancer. It carries out this role by…”
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Comparative functional analysis of the molecular network of 7 selected MLL fusion proteins by Skucha, Anna, Stukalov, Alexey, Muhar, Matthias, Colinge, Jacques, Bennett, Keiryn, Zuber, Johannes, Superti-Furga, Giulio, Grebien, Florian

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abFASP-MS: Affinity-Based Filter-Aided Sample Preparation Mass Spectrometry for Quantitative Analysis of Chemically Labeled Protein Complexes by Huber, Marie L, Sacco, Roberto, Parapatics, Katja, Skucha, Anna, Khamina, Kseniya, Müller, André C, Rudashevskaya, Elena L, Bennett, Keiryn L

“…Affinity purification coupled to 1-D gel-free liquid chromatography mass spectrometry (LC–MS) is a well-established and widespread approach for the analyses of…”
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Comparative functional analysis of the molecular network of 7 selected MLL fusion proteins by Skucha, Anna, Stukalov, Alexey, Muhar, Matthias, Colinge, Jacques, Bennett, Keiryn, Zuber, Johannes, Superti-Furga, Giulio, Grebien, Florian

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Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis by Pencik, Jan, Schlederer, Michaela, Gruber, Wolfgang, Unger, Christine, Walker, Steven M., Chalaris, Athena, Marié, Isabelle J., Hassler, Melanie R., Javaheri, Tahereh, Aksoy, Osman, Blayney, Jaine K., Prutsch, Nicole, Skucha, Anna, Herac, Merima, Krämer, Oliver H., Mazal, Peter, Grebien, Florian, Egger, Gerda, Poli, Valeria, Mikulits, Wolfgang, Eferl, Robert, Esterbauer, Harald, Kennedy, Richard, Fend, Falko, Scharpf, Marcus, Braun, Martin, Perner, Sven, Levy, David E., Malcolm, Tim, Turner, Suzanne D., Haitel, Andrea, Susani, Martin, Moazzami, Ali, Rose-John, Stefan, Aberger, Fritz, Merkel, Olaf, Moriggl, Richard, Culig, Zoran, Dolznig, Helmut, Kenner, Lukas

“…Nature Communications 6: Article number:7736 (2015); Published: 22 July 2015; Updated: 26 October 2015 The affiliation details for Jan Pencik are incorrect in…”
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Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBP[alpha] N-terminal leukemia by Grebien, Florian, Vedadi, Masoud, Getlik, Matthäus, Giambruno, Roberto, Grover, Amit, Avellino, Roberto, Skucha, Anna, Vittori, Sarah, Kuznetsova, Ekaterina, Smil, David, Barsyte-lovejoy, Dalia, Li, Fengling, Poda, Gennadiy, Schapira, Matthieu, Wu, Hong, Dong, Aiping, Senisterra, Guillermo, Stukalov, Alexey, Huber, Kilian V M, Schönegger, Andreas, Marcellus, Richard, Bilban, Martin, Bock, Christoph, Brown, Peter J, Zuber, Johannes, Bennett, Keiryn L, Al-awar, Rima, Delwel, Ruud, Nerlov, Claus, Arrowsmith, Cheryl H, Superti-furga, Giulio

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Pharmacological targeting of the Wdr5-MLL interaction in C/EBP[alpha] N-terminal leukemia by Grebien, Florian, Vedadi, Masoud, Getlik, Matthäus, Giambruno, Roberto, Grover, Amit, Avellino, Roberto, Skucha, Anna, Vittori, Sarah, Kuznetsova, Ekaterina, Smil, David, Barsyte-lovejoy, Dalia, Li, Fengling, Poda, Gennadiy, Schapira, Matthieu, Wu, Hong, Dong, Aiping, Senisterra, Guillermo, Stukalov, Alexey, Huber, Kilian V M, Schönegger, Andreas, Marcellus, Richard, Bilban, Martin, Bock, Christoph, Brown, Peter J, Zuber, Johannes, Bennett, Keiryn L, Al-awar, Rima, Delwel, Ruud, Nerlov, Claus, Arrowsmith, Cheryl H, Superti-furga, Giulio

“…The CEBPA gene is mutated in 9% of patients with acute myeloid leukemia (AML). Selective expression of a short (30-kDa) CCAAT-enhancer binding protein-a…”
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Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia by Grebien, Florian, Vedadi, Masoud, Getlik, Matthäus, Giambruno, Roberto, Grover, Amit, Avellino, Roberto, Skucha, Anna, Vittori, Sarah, Kuznetsova, Ekaterina, Smil, David, Barsyte-Lovejoy, Dalia, Li, Fengling, Poda, Gennadiy, Schapira, Matthieu, Wu, Hong, Dong, Aiping, Senisterra, Guillermo, Stukalov, Alexey, Huber, Kilian V M, Schönegger, Andreas, Marcellus, Richard, Bilban, Martin, Bock, Christoph, Brown, Peter J, Zuber, Johannes, Bennett, Keiryn L, Al-awar, Rima, Delwel, Ruud, Nerlov, Claus, Arrowsmith, Cheryl H, Superti-Furga, Giulio

“…Nat. Chem. Biol. 11, 571–578 (2015); published online 13 July 2015; corrected online 20 August 2015 In the author list, affiliation and correspondence…”
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