Search Results - "Skrygan, Marina"

MicroRNAs and the skin: Tiny players in the body's largest organ by Sand, Michael, Gambichler, Thilo, Sand, Daniel, Skrygan, Marina, Altmeyer, Peter, Bechara, Falk G

“…Abstract MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22–25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs…”
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Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma by Gambichler, Thilo, Sand, Michael, Skrygan, Marina

“…Several research groups have recently reported on markedly reduced levels of 5-hydroxymethylcytosine (5hmC) in human breast, liver, lung, pancreatic, colon,…”
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Microarray analysis of microRNA expression in cutaneous squamous cell carcinoma by Sand, Michael, Skrygan, Marina, Georgas, Dimitrios, Sand, Daniel, Hahn, Stephan A, Gambichler, Thilo, Altmeyer, Peter, Bechara, Falk G

“…Abstract Background MicroRNAs (miRNAs) are a novel class of short RNAs that are capable epigenetically regulating gene expression in eukaryotes. MicroRNAs have…”
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In Vitro Experiments on the Effects of GP-2250 on BRAF-Mutated Melanoma Cell Lines and Benign Melanocytes by Gambichler, Thilo, Harnischfeger, Friederike, Skrygan, Marina, Majchrzak-Stiller, Britta, Buchholz, Marie, Müller, Thomas, Braumann, Chris

“…Enhanced glycolysis (Warburg effect) driven by the BRAF oncogene, dysregulated GAPDH expression, and activation of the PI3K/AKT/mTOR signaling pathway may…”
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Comparative microarray analysis of microRNA expression profiles in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases, and benign melanocytic nevi by Sand, Michael, Skrygan, Marina, Sand, Daniel, Georgas, Dimitrios, Gambichler, Thilo, Hahn, Stephan A, Altmeyer, Peter, Bechara, Falk G

“…Perturbations in microRNA (miRNA) expression profiles have been reported for cutaneous malignant melanoma (CMM) predominantly when examined in cell lines…”
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Epithelial Antimicrobial Peptide/Protein and Cytokine Expression Profiles Obtained from Nasopharyngeal Swabs of SARS-CoV-2-Infected and Non-Infected Subjects by Gambichler, Thilo, Goesmann, Silke, Skrygan, Marina, Susok, Laura, Schütte, Christian, Hamdani, Nahza, Schmidt, Wolfgang

“…Immune responses of the epithelia of the upper respiratory tract are likely crucial in early inhibition of the viral replication and finally clearance of…”
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Expression of oncogenic miR-17-92 and tumor suppressive miR-143-145 clusters in basal cell carcinoma and cutaneous squamous cell carcinoma by Sand, Michael, Hessam, Schapoor, Amur, Susanne, Skrygan, Marina, Bromba, Michael, Stockfleth, Eggert, Gambichler, Thilo, Bechara, Falk G

“…Highlights • microRNAs can have an oncogenic or tumor-supressive effect. • miR-17-92 cluster (Oncomir-1) is oncogenic and miR-143-145 tumor supressive. •…”
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Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer by Sand, Michael, Skrygan, Marina, Georgas, Dimitrios, Arenz, Christoph, Gambichler, Thilo, Sand, Daniel, Altmeyer, Peter, Bechara, Falk G.

“…The microprocessor complex mediates intranuclear biogenesis of precursor microRNAs from the primary microRNA transcript. Extranuclear, mature microRNAs are…”
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Inflammation induced changes in the expression levels of components of the microRNA maturation machinery Drosha, Dicer, Drosha co-factor DGRC8 and Exportin-5 in inflammatory lesions of hidradenitis suppurativa patients by Hessam, Schapoor, Sand, Michael, Skrygan, Marina, Gambichler, Thilo, Bechara, Falk G

“…Highlights • Deregulation of microRNAs may contribute to the pathogenesis in inflammatory diseases. • microRNA key regulators are dysregulated in hidradenitis…”
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A Prospective Study Investigating Immune Checkpoint Molecule and CD39 Expression on Peripheral Blood Cells for the Prognostication of COVID-19 Severity and Mortality by Gambichler, Thilo, Rüth, Jonas, Goesmann, Silke, Höxtermann, Stefan, Skrygan, Marina, Susok, Laura, Becker, Jürgen C, Overheu, Oliver, Schmidt, Wolfgang, Reinacher-Schick, Anke

“…In patients with COVID-19, broad panels of immune checkpoint molecules (ICPMs) and the purinergic signaling have not been studied in parallel. We aimed to…”
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Expression of antimicrobial peptides in different subtypes of cutaneous lupus erythematosus by Kreuter, Alexander, MD, Jaouhar, Mohamed, MD, Skrygan, Marina, PhD, Tigges, Christian, MD, Stücker, Markus, MD, Altmeyer, Peter, MD, Gläser, Regine, MD, Gambichler, Thilo, MD

“…Background Antimicrobial peptides (AMPs) are small effector molecules of the innate immune system with well-known antimicrobial activity. Skin infections…”
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Patched 1 expression in Merkel cell carcinoma by Gambichler, Thilo, Dreißigacker, Max, Kasakovski, Dimitri, Skrygan, Marina, Wieland, Ulrike, Silling, Steffi, Gravemeyer, Jan, Melior, Anita, Cherouny, Angela, Stücker, Markus, Stockfleth, Eggert, Sand, Michael, Becker, Jürgen C.

“…The relevance of Hedgehog signaling in Merkel cell carcinoma has only been addressed by a few studies with conflicting results. Thus, we aimed to establish the…”
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Expression of Mismatch Repair Proteins in Merkel Cell Carcinoma by Gambichler, Thilo, Abu Rached, Nessr, Tannapfel, Andrea, Becker, Jürgen C., Vogt, Markus, Skrygan, Marina, Wieland, Ulrike, Silling, Steffi, Susok, Laura, Stücker, Markus, Meyer, Thomas, Stockfleth, Eggert, Junker, Klaus, Käfferlein, Heiko U., Brüning, Thomas, Lang, Kerstin

“…We aimed to assess for the first time the mismatch repair (MMR) protein expression in Merkel cell carcinoma (MCC). Immunohistochemistry was performed for MLH1,…”
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Expression Levels of the microRNA Processing Enzymes Drosha and Dicer in Epithelial Skin Cancer by Sand, Michael, Gambichler, Thilo, Skrygan, Marina, Sand, Daniel, Scola, Nina, Altmeyer, Peter, Bechara, Falk G.

“…ABSTRACT Background: Dysregulation of microRNA (miRNA) metabolism has been observed in a variety of human cancers. In this pilot study, we investigated…”
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Mismatch Repair Protein Expression and Microsatellite Instability in Cutaneous Squamous Cell Carcinoma by Gambichler, Thilo, Ganjuur, Nomun, Tannapfel, Andrea, Vogt, Markus, Scholl, Lisa, Abu Rached, Nessr, Bruckmüller, Stefanie, Skrygan, Marina, Becker, Jürgen C., Käfferlein, Heiko U., Brüning, Thomas, Lang, Kerstin

“…There exist relatively sparse and conflicting data on high-level microsatellite instability (MSI-H) and deficient mismatch repair (dMMR) in cutaneous…”
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Acne inversa: evaluating antimicrobial peptides and proteins by Bechara, Falk G, Sand, Michael, Skrygan, Marina, Kreuter, Alexander, Altmeyer, Peter, Gambichler, Thilo

“…Acne inversa is a chronic, suppurative relapsing inflammatory skin disease that primarily affects the axillae, perineum and inframammary regions. Evidence…”
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An In Vitro Pilot Study Investigating the Antineoplastic Effects of GP-2250 on Cutaneous Squamous Cell Carcinoma Cell Lines: Preliminary Results by Barras, Milan, Schmitz, Lutz, Braumann, Chris, Uhl, Waldemar, Skrygan, Marina, Buchholz, Marie, Meyer, Thomas, Stockfleth, Eggert, Müller, Thomas, Becker, Jürgen C., Gambichler, Thilo

“…Advanced cutaneous squamous cell carcinoma (cSCC) can be a life-threatening disease for which effective and safe treatment in advanced stages is very limited…”
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Differential mRNA expression of antimicrobial peptides and proteins in atopic dermatitis as compared to psoriasis vulgaris and healthy skin by Gambichler, Thilo, Skrygan, Marina, Tomi, Nordwig S, Othlinghaus, Nick, Brockmeyer, Norbert H, Altmeyer, Peter, Kreuter, Alexander

“…Patients with atopic dermatitis (AD) are prone to have skin infections. We aimed to investigate mRNA expression levels of various antimicrobial peptides and…”
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Expression of antimicrobial peptides and proteins in epidermis equivalents exposed to salt water and narrowband ultraviolet B radiation by Gambichler, Thilo, Terras, Sarah, Skrygan, Marina

“…KCI Citation Count: 1…”
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Cytokine and chemokine ligand expression in cutaneous lupus erythematosus by GAMBICHLERQ, Thilo, GENC, Zanna, SKRYGAN, Marina, SCOLA, Nina, TIGGES, Christian, TERRAS, Sarah, BECHARA, Falk G, KREUTER, Alexander

“…There is increasing evidence that cytokines as well as chemokines are important players in the pathogenesis of lupus erythematosus (LE). We aimed to compare…”
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