Search Results - "Skottman, H"

Introduction to the stem cell derived transplants by Skottman, H.

“…Summary Stem cell therapy is a potential approach for the replacement of degenerated cells of the eye. For retinal diseases such as age related macular…”
Get full text

Human pluripotent stem cells as a source of corneal epithelium by Skottman, H.

“…Summary In healthy cornea, epithelium is renewed by limbal stem cells (LSCs) and LSCs transplantation has been used to treat limbal stem cell deficiency…”
Get full text

Good manufacturing practice and clinical-grade human embryonic stem cell lines by Unger, Christian, Skottman, Heli, Blomberg, Pontus, Sirac Dilber, M., Hovatta, Outi

“…Human embryonic stem cell (hESC) lines, after directed differentiation, hold the greatest potential for cell transplantation treatment in many severe diseases…”
Get full text

Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders by Auvinen, P, Vehviläinen, J, Marjonen, H, Modhukur, V, Sokka, J, Wallén, E, Rämö, K, Ahola, L, Salumets, A, Otonkoski, T, Skottman, H, Ollikainen, M, Trokovic, R, Kahila, H, Kaminen-Ahola, N

“…Prenatal alcohol exposure (PAE) affects embryonic development, causing a variable fetal alcohol spectrum disorder (FASD) phenotype with neuronal disorders and…”
Get full text

Contacting co-culture of human retinal microvascular endothelial cells alters barrier function of human embryonic stem cell derived retinal pigment epithelial cells by Skottman, H., Muranen, J., Lähdekorpi, H., Pajula, E., Mäkelä, K., Koivusalo, L., Koistinen, A., Uusitalo, H., Kaarniranta, K., Juuti-Uusitalo, K.

“…Here we evaluated the effects of human retinal microvascular endothelial cells (hREC) on mature human embryonic stem cell (hESC) derived retinal pigment…”
Get full text

Novel roles for voltage sensitive ion channels in retinal pigment epithelium and phagocytosis by Nymark, S., Johansson, J. K., Skottman, H., Ihalainen, T.O.

“…Summary Photoreceptors of the retina undergo a daily renewal process where they shed 10% of their outer segment disks that are then digested by the retinal…”
Get full text

Intercellular Ca(2+) wave propagation in human retinal pigment epithelium cells induced by mechanical stimulation by Abu Khamidakh, A E, Juuti-Uusitalo, K, Larsson, K, Skottman, H, Hyttinen, J

“…Ca(2+) signaling is vitally important in cellular physiological processes and various drugs also affect Ca(2+) signaling. Thus, knowledge of Ca(2+) dynamics is…”
Get full text

Markers of pluripotency and differentiation in human neural precursor cells derived from embryonic stem cells and CNS tissue by Sundberg, M, Andersson, P-H, Åkesson, E, Odeberg, J, Holmberg, L, Inzunza, J, Falci, S, Öhman, J, Suuronen, R, Skottman, H, Lehtimäki, K, Hovatta, O, Narkilahti, S, Sundström, E

“…Cell transplantation therapies for central nervous system (CNS) deficits such as spinal cord injury (SCI) have been shown to be effective in several animal…”
Get full text

Intercellular Ca2+ wave propagation in human retinal pigment epithelium cells induced by mechanical stimulation by Abu Khamidakh, A.E., Juuti-Uusitalo, K., Larsson, K., Skottman, H., Hyttinen, J.

“…Ca2+ signaling is vitally important in cellular physiological processes and various drugs also affect Ca2+ signaling. Thus, knowledge of Ca2+ dynamics is…”
Get full text

Spontaneous and mechanically induced Ca2+ activity changes in hESC‐RPE cells during maturation by Abu Khamidakh, A., Juuti‐Uusitalo, K., Caetano dos Santos, F., Skottman, H., Hyttinen, J.

“…Purpose The aim of this study was to investigate changes in spontaneous Ca2+ activity and mechanically induced intercellular Ca2+ communication in human…”
Get full text

Proteomic tools for studying RPE functions by Hongisto, H., Jylhä, A., Nättinen, J., Rieck, J., Ilmarinen, T., Veréb, Z., Aapola, U., Beuerman, R., Petrovski, G., Uusitalo, H., Skottman, H.

“…Summary Human embryonic stem cell‐derived retinal pigment epithelial cells (hESC‐RPE) provide a promising cell source for studying retinal development, for…”
Get full text

Fluorescent probes as a tool for cell population tracking in spontaneously active neural networks derived from human pluripotent stem cells by Mäkinen, M., Joki, T., Ylä-Outinen, L., Skottman, H., Narkilahti, S., Äänismaa, R.

“…•Fluorescent labels CT and DiD can be utilized with human stem cell-derived neurons.•Labels do not affect the cell viability and minimally affect the cell…”
Get full text

Impedance Spectroscopy in Monitoring the Maturation of Stem Cell-Derived Retinal Pigment Epithelium by Savolainen, V., Juuti-Uusitalo, K., Onnela, N., Vaajasaari, H., Narkilahti, S., Suuronen, R., Skottman, H., Hyttinen, J.

“…The development and differentiation of stem cell-derived impermeable retinal pigment epithelium (RPE) with tight junctions (TJs) is a gradual process that is,…”
Get full text

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage by Amps, Katherine, Andrews, Peter W, Anyfantis, George, Armstrong, Lyle, Avery, Stuart, Baharvand, Hossein, Baker, Julie, Baker, Duncan, Munoz, Maria B, Beil, Stephen, Benvenisty, Nissim, Ben-Yosef, Dalit, Biancotti, Juan-Carlos, Bosman, Alexis, Brena, Romulo Martin, Brison, Daniel, Caisander, Gunilla, Camarasa, María V, Chen, Jieming, Chiao, Eric, Choi, Young Min, Choo, Andre B H, Collins, Daniel, Colman, Alan, Crook, Jeremy M, Daley, George Q, Dalton, Anne, De Sousa, Paul A, Denning, Chris, Downie, Janet, Dvorak, Petr, Montgomery, Karen D, Feki, Anis, Ford, Angela, Fox, Victoria, Fraga, Ana M, Frumkin, Tzvia, Ge, Lin, Gokhale, Paul J, Golan-Lev, Tamar, Gourabi, Hamid, Gropp, Michal, Lu, Guangxiu, Hampl, Ales, Harron, Katie, Healy, Lyn, Herath, Wishva, Holm, Frida, Hovatta, Outi, Hyllner, Johan, Inamdar, Maneesha S, Irwanto, Astrid Kresentia, Ishii, Tetsuya, Jaconi, Marisa, Jin, Ying, Kimber, Susan, Kiselev, Sergey, Knowles, Barbara B, Kopper, Oded, Kukharenko, Valeri, Kuliev, Anver, Lagarkova, Maria A, Laird, Peter W, Lako, Majlinda, Laslett, Andrew L, Lavon, Neta, Lee, Dong Ryul, Lee, Jeoung Eun, Li, Chunliang, Lim, Linda S, Ludwig, Tenneille E, Ma, Yu, Maltby, Edna, Mateizel, Ileana, Mayshar, Yoav, Mileikovsky, Maria, Minger, Stephen L, Miyazaki, Takamichi, Moon, Shin Yong, Moore, Harry, Mummery, Christine, Nagy, Andras, Nakatsuji, Norio, Narwani, Kavita, Oh, Steve K W, Oh, Sun Kyung, Olson, Cia, Otonkoski, Timo, Pan, Fei, Park, In-Hyun, Pells, Steve, Pera, Martin F, Pereira, Lygia V, Qi, Ouyang, Raj, Grace Selva, Reubinoff, Benjamin, Robins, Alan, Robson, Paul, Rossant, Janet, Salekdeh, Ghasem H

“…The International Stem Cell Initiative compares 125 ethnically diverse human embryonic stem cell lines at early and late passage. Data on karotype,…”
Get full text

Stem cell applications for retinal pigment epithelial cell defects by SKOTTMAN, H

“…Purpose The experimental data on the retinal pigment epithelium (RPE) transplantation clearly show the potential of the cell therapy treatment strategy for RPE…”
Get full text

Toward the defined and xeno-free differentiation of functional human pluripotent stem cell-derived retinal pigment epithelial cells by Vaajasaari, Hanna, Ilmarinen, Tanja, Juuti-Uusitalo, Kati, Rajala, Kristiina, Onnela, Niina, Narkilahti, Susanna, Suuronen, Riitta, Hyttinen, Jari, Uusitalo, Hannu, Skottman, Heli

“…The production of functional retinal pigment epithelium (RPE) cells from human embryonic (hESCs) and human induced pluripotent stem cells (hiPSCs) in defined…”
Get full text

Patient-specific induced pluripotent stem cell-derived RPE cells: Understanding the pathogenesis of retinopathy in long-chain 3-hydroxyacyl-CoA dehydrogenase deiciency by Polinati, P. P., Ilmarinen, T., Trokovic, R., Hyötyläinen, Tuulia, Otonkoski, T., Suomalainen, A., Skottman, H., Tynitiina, T.

“…Purpose: Retinopathy is an important manifestation of trifunctional protein (TFP) deficiencies but not of other defects of fatty acid oxidation. The common…”
Get full text

A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells by Rajala, Kristiina, Lindroos, Bettina, Hussein, Samer M, Lappalainen, Riikka S, Pekkanen-Mattila, Mari, Inzunza, Jose, Rozell, Björn, Miettinen, Susanna, Narkilahti, Susanna, Kerkelä, Erja, Aalto-Setälä, Katriina, Otonkoski, Timo, Suuronen, Riitta, Hovatta, Outi, Skottman, Heli

“…The growth of stem cells in in vitro conditions requires optimal balance between signals mediating cell survival, proliferation, and self-renewal. For clinical…”
Get full text

Derivation of Human Embryonic Stem Cell Lines in Serum Replacement Medium Using Postnatal Human Fibroblasts as Feeder Cells by Inzunza, José, Gertow, Karin, Strömberg, Marie A., Matilainen, Eija, Blennow, Elisabeth, Skottman, Heli, Wolbank, Susanne, Ährlund‐Richter, Lars, Hovatta, Outi

“…Derivation and culture of human embryonic stem cells (hESCs) without animal‐derived material would be optimal for cell transplantation. We derived two new hES…”
Get full text

Transcriptome profiling of human pre-implantation development by Zhang, Pu, Zucchelli, Marco, Bruce, Sara, Hambiliki, Fredwell, Stavreus-Evers, Anneli, Levkov, Lev, Skottman, Heli, Kerkelä, Erja, Kere, Juha, Hovatta, Outi

“…Preimplantation development is a crucial step in early human development. However, the molecular basis of human preimplantation development is not well known…”
Get full text