Search Results - "Skorupski, Karen"

The LysR-Type Virulence Activator AphB Regulates the Expression of Genes in Vibrio cholerae in Response to Low pH and Anaerobiosis by KOVACIKOVA, Gabriela, WEI LIN, SKORUPSKI, Karen

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Proteolysis of virulence regulator ToxR is associated with entry of Vibrio cholerae into a dormant state by Almagro-Moreno, Salvador, Kim, Tae K, Skorupski, Karen, Taylor, Ronald K

“…Vibrio cholerae O1 is a natural inhabitant of aquatic environments and causes the diarrheal disease, cholera. Two of its primary virulence regulators, TcpP and…”
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Structure of Vibrio cholerae ToxT Reveals a Mechanism for Fatty Acid Regulation of Virulence Genes by Lowden, Michael J., Skorupski, Karen, Pellegrini, Maria, Chiorazzo, Michael G., Taylor, Ronald K., Kull, F. Jon, Mekalanos, John J.

“…Cholera is an acute intestinal infection caused by the bacterium Vibrio cholerae. In order for V. cholerae to cause disease, it must produce two virulence…”
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quorum sensing regulator HapR downregulates the expression of the virulence gene transcription factor AphA in Vibrio cholerae by antagonizing Lrp- and VpsR-mediated activation by Lin, Wei, Kovacikova, Gabriela, Skorupski, Karen

“…HapR is a quorum sensing-regulated transcription factor that represses the virulence cascade in Vibrio cholerae by binding to a specific site centred at -71 in…”
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H-NS Binding and Repression of the ctx Promoter in Vibrio cholerae by STONEHOUSE, Emily A, HULBERT, Robin R, NYE, Melinda B, SKORUPSKI, Karen, TAYLOR, Ronald K

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Integration Host Factor Positively Regulates Virulence Gene Expression in Vibrio cholerae by STONEHOUSE, Emily, KOVACIKOVA, Gabriela, TAYLOR, Ronald K, SKORUPSKI, Karen

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Overlapping binding sites for the virulence gene regulators AphA, AphB and cAMP‐CRP at the Vibrio cholerae tcpPH promoter by Kovacikova, Gabriela, Skorupski, Karen

“…The expression of the Vibrio cholerae virulence factors, toxin‐co‐regulated pilus (TCP) and cholera toxin (CT), are dependent on the ability of the LysR…”
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Levels of the Secreted Vibrio cholerae Attachment Factor GbpA Are Modulated by Quorum-Sensing-Induced Proteolysis by JUDE, Brooke A, MARTINEZ, Raquel M, SKORUPSKI, Karen, TAYLOR, Ronald K

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A Vibrio cholerae LysR Homolog, AphB, Cooperates with AphA at the tcpPH Promoter To Activate Expression of the ToxR Virulence Cascade by Kovacikova, G, Skorupski, K

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Characterization of BreR Interaction with the Bile Response Promoters breAB and breR in Vibrio cholerae by Cerda-Maira, Francisca A, Kovacikova, Gabriela, Jude, Brooke A, Skorupski, Karen, Taylor, Ronald K

“…The Vibrio cholerae BreR protein is a transcriptional repressor of the breAB efflux system operon, which encodes proteins involved in bile resistance. In a…”
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Role of FlgT in Anchoring the Flagellum of Vibrio cholerae by MARTINEZ, Raquel M, JUDE, Brooke A, KIRN, Thomas J, SKORUPSKI, Karen, TAYLOR, Ronald K

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Requirements for Vibrio cholerae HapR Binding and Transcriptional Repression at the hapR Promoter Are Distinct from Those at the aphA Promoter by WEI LIN, KOVACIKOVA, Gabriela, SKORUPSKI, Karen

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Crystal Structure of the Vibrio cholerae Quorum-Sensing Regulatory Protein HapR by DE SILVA, Rukman S, KOVACIKOVA, Gabriela, WEI LIN, TAYLOR, Ronald K, SKORUPSKI, Karen, KULL, F. Jon

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Control of the ToxR virulence regulon in Vibrio cholerae by environmental stimuli by Skorupski, Karen, Taylor, Ronald K.

“…Many bacterial pathogens regulate the expression of virulence genes in a co‐ordinate manner in response to changes in the environment. For example, the human…”
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The Virulence Activator AphA Links Quorum Sensing to Pathogenesis and Physiology in Vibrio cholerae by Repressing the Expression of a Penicillin Amidase Gene on the Small Chromosome by Kovacikova, Gabriela, Lin, Wei, Skorupski, Karen

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Crystal Structure of the Virulence Gene Activator AphA from Vibrio cholerae Reveals It Is a Novel Member of the Winged Helix Transcription Factor Superfamily by De Silva, Rukman S., Kovacikova, Gabriela, Lin, Wei, Taylor, Ronald K., Skorupski, Karen, Kull, F. Jon

“…AphA is a member of a new and largely uncharacterized family of transcriptional activators that is required for initiating virulence gene expression in Vibrio…”
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Vibrio cholerae H-NS Silences Virulence Gene Expression at Multiple Steps in the ToxR Regulatory Cascade by Nye, M B, Pfau, J D, Skorupski, K, Taylor, R K

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Cyclic AMP and its Receptor Protein Negatively Regulate the Coordinate Expression of Cholera Toxin and Toxin-Coregulated Pilus in Vibrio cholerae by Skorupski, Karen, Taylor, Ronald K.

“…Insertion mutations in two Vibrio cholerae genes, cya and crp, which encode adenylate cyclase and the cyclic AMP (cAMP) receptor protein (CRP), respectively,…”
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The Alternative Sigma Factor σE Plays an Important Role in Intestinal Survival and Virulence in Vibrio cholerae by KOVACIKOVA, Gabriela, SKORUPSKI, Karen

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Bile salts and alkaline pH reciprocally modulate the interaction between the periplasmic domains of Vibrio cholerae ToxR and ToxS by Midgett, Charles R., Almagro‐Moreno, Salvador, Pellegrini, Maria, Taylor, Ronald K., Skorupski, Karen, Kull, F. Jon

“…Summary ToxR is a transmembrane transcription factor that is essential for virulence gene expression and human colonization by Vibrio cholerae. ToxR requires…”
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