Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo

Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo

•Chronic consumption of green tea catechins in low doses seems to be safe.•Overdose consumption of catechins modulates several drug-metabolizing enzymes.•Short-term overdose consumption had more pronounced effect than long-term one. Green tea represents a favourite beverage and green tea extracts ar...

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Bibliographic Details
Published in:Journal of functional foods Vol. 10; pp. 327 - 335
Main Authors: Matoušková, Petra, Bártíková, Hana, Boušová, Iva, Szotáková, Barbora, Martin, Jan, Skorkovská, Jana, Hanušová, Veronika, Tománková, Veronika, Anzenbacherová, Eva, Lišková, Barbora, Anzenbacher, Pavel, Skálová, Lenka
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-09-2014
Elsevier
Subjects:
Biotransformation
Dietary supplement
Drug interaction
Flavonoids
Induction
Inhibition
Dietary supplement
Flavonoids
Drug interaction
Inhibition
Induction
Biotransformation
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Summary:•Chronic consumption of green tea catechins in low doses seems to be safe.•Overdose consumption of catechins modulates several drug-metabolizing enzymes.•Short-term overdose consumption had more pronounced effect than long-term one. Green tea represents a favourite beverage and green tea extracts are popular components of dietary supplements. The aim of present in vivo study was to report on the effect of defined green tea extract (Polyphenon) in various dosage schemes on drug-metabolizing enzymes in mice. The specific activities and expressions of a panel of drug-metabolizing enzymes (totally 16) were tested in liver and small intestine. Nine enzymes were significantly altered by Polyphenon treatment. The intestinal enzymes were more affected than the hepatic ones. The effects were mostly dose-dependent but short-term treatment had more pronounced impact than the long-term administration. Based on the results, normal consumption of green tea seems to be safe but extremely high doses of green tea extracts in dietary supplements could influence drugs metabolism and efficacy.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2014.06.026