Search Results - "Skoko, Natasa"

Expression, purification and characterization of SARS-CoV-2 spike RBD in ExpiCHO cells by De March, Matteo, Terdoslavich, Michela, Polez, Sulena, Guarnaccia, Corrado, Poggianella, Monica, Marcello, Alessandro, Skoko, Nataša, de Marco, Ario

“…Reliable diagnosis is critical to identify infections of SARS-CoV-2 as well as to evaluate the immune response to virus and vaccines. Consequently, it becomes…”
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Inhibitors of Protein Glycosylation Are Active against the Coronavirus Severe Acute Respiratory Syndrome Coronavirus SARS-CoV-2 by Rajasekharan, Sreejith, Milan Bonotto, Rafaela, Nascimento Alves, Lais, Kazungu, Yvette, Poggianella, Monica, Martinez-Orellana, Pamela, Skoko, Natasa, Polez, Sulena, Marcello, Alessandro

“…Repurposing clinically available drugs to treat the new coronavirus disease 2019 (COVID-19) is an urgent need in the course of the Severe Acute Respiratory…”
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Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance by Cragnaz, Lucia, Spinelli, Greta, De Conti, Laura, Bureau, Emilie A., Brownlees, Janet, Feiguin, Fabian, Romano, Valentina, Skoko, Natasa, Klima, Raffaella, Kettleborough, Catherine A., Baralle, Francisco E., Baralle, Marco

“…Brain inclusions mainly composed of misfolded and aggregated TAR DNA binding protein 43 (TDP-43), are characteristic hallmarks of amyotrophic lateral sclerosis…”
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Binding of DAZAP1 and hnRNPA1/A2 to an Exonic Splicing Silencer in a Natural BRCA1 Exon 18 Mutant by Goina, Elisa, Skoko, Natasa, Pagani, Franco

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Antimycobacterial activity of new N 1 -[1-[1-aryl-3-[4-(1 H -imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives by Zampieri, Daniele, Mamolo, Maria Grazia, Vio, Luciano, Romano, Maurizio, Skoko, Nataša, Baralle, Marco, Pau, Valentina, De Logu, Alessandro

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Aggregate formation prevents dTDP-43 neurotoxicity in the Drosophila melanogaster eye by Cragnaz, Lucia, Klima, Raffaela, Skoko, Natasa, Budini, Mauricio, Feiguin, Fabian, Baralle, Francisco E

“…Abstract TDP-43 inclusions are an important histopathological feature in various neurodegenerative disorders, including Amyotrophic Lateral Sclerosis and…”
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Application of simple fed-batch technique to high-level secretory production of insulin precursor using Pichia pastoris with subsequent purification and conversion to human insulin by Gurramkonda, Chandrasekhar, Polez, Sulena, Skoko, Natasa, Adnan, Ahmad, Gäbel, Thomas, Chugh, Dipti, Swaminathan, Sathyamangalam, Khanna, Navin, Tisminetzky, Sergio, Rinas, Ursula

“…The prevalence of diabetes is predicted to rise significantly in the coming decades. A recent analysis projects that by the year 2030 there will be ~366…”
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NF1 mRNA biogenesis: Effect of the genomic milieu in splicing regulation of the NF1 exon 37 region by Baralle, Marco, Skoko, Natasa, Knezevich, Anna, De Conti, Laura, Motti, Dario, Bhuvanagiri, Madhuri, Baralle, Diana, Buratti, Emanuele, Baralle, Francisco E.

“…We have studied the splicing regulation of NF1 exons 36 and 37. We show that they not only require an intact exonic Splicing Enhancer (ESE) within exon 37, but…”
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Complexities of 5'splice site definition: Implications in clinical analyses by De Conti, Laura, Skoko, Natasa, Buratti, Emanuele, Baralle, Marco

“…In higher eukaryotes, the 5' splice site (5'ss) is initially recognized through an RNA-RNA interaction by U1 small nuclear ribonucleoprotein (U1 snRNP). This…”
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A Simplified and Efficient Process for Insulin Production in Pichia pastoris by Polez, Sulena, Origi, Domenico, Zahariev, Sotir, Guarnaccia, Corrado, Tisminetzky, Sergio G, Skoko, Nataša, Baralle, Marco

“…A significant barrier to insulin is affordability. In this manuscript we describe improvements to key steps in the insulin production process in Pichia…”
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High Throughput miRNA Screening Identifies miR-574-3p Hyperproductive Effect in CHO Cells by Švab, Živa, Braga, Luca, Guarnaccia, Corrado, Labik, Ivan, Herzog, Jeremias, Baralle, Marco, Giacca, Mauro, Skoko, Nataša

“…CHO is the cell line of choice for the manufacturing of many complex biotherapeutics. The constant upgrading of cell productivity is needed to meet the growing…”
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Construction of Saccharomyces cerevisiae strain FAV20 useful in detection of immunosuppressants produced by soil actinomycetes by Skoko, Natasa, Vujovic, Jelena, Savic, Miloje, Papic, Natasa, Vasiljevic, Branka, Ljubijankic, Goran

“…The screening of microbial natural products continues to represent an important route to the discovery of novel chemicals for development of new therapeutic…”
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Some things old, new and borrowed: Delivery of dabrafenib and vemurafenib to melanoma cells via self-assembled nanomicelles based on an amphiphilic dendrimer by Russi, Maria, Valeri, Rachele, Marson, Domenico, Danielli, Chiara, Felluga, Fulvia, Tintaru, Aura, Skoko, Natasa, Aulic, Suzana, Laurini, Erik, Pricl, Sabrina

“…Two clinically approved anticancer drugs targeting BRAF in melanoma patients – dabrafenib (DAB) and vemurafenib (VEM) – have been successfully encapsulated…”
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Absence of TDP-43 is difficult to digest by Skoko, Natasa, Baralle, Marco, Baralle, Francisco E

“…It is well established that TDP‐43 accumulates in degenerating neurons in patients with ALS/FTLD, which might affect normal TDP‐43 function. In this issue of…”
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Abstract 2382: In silico/in vitro studies of novel hot spot mutations in BCR-ABL1: A multidisciplinary approach to shed a new light on TKI resistance by Laurini, Erik, Aulic, Suzana, Skoko, Natasa, Polez, Sulena, Baralle, Marco, Romano, Maurizio, Pricl, Sabrina

“…Acquisition of mutations in the BCR-ABL1 kinase domain (KD) is frequently associated with tyrosine kinase inhibitor (TKI) failure in CML. Recently, we revealed…”
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Production of glycosylated thermostable Providencia rettgeri penicillin G amidase in Pichia pastoris by Ševo, Milica, Degrassi, Giuliano, Skoko, Nataša, Venturi, Vittorio, Ljubijankić, Goran

“…Penicillin G amidase from Providencia rettgeri is a heterodimer of 92 kDa. We have previously expressed the Pr. rettgeri pac gene coding for this enzyme in…”
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InTRONs in Biotech by Skoko, Natasa, Baralle, Marco, Tisminetzky, Sergio, Buratti, Emanuele

“…Eukaryotic gene expression relies on several complex molecular machineries that act in a highly coordinated fashion. These machineries govern all the different…”
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Dual Role of Dextran Sulfate 5000Â Da as Anti-Apoptotic and Pro-Autophagy Agent by Menvielle, J Pedro, Safini, Najete, Tisminetzky, Sergio G, Skoko, Natasa

“…Dextran sulfate 5,000Â Da (DS), a sulfated polysaccharide, has been used in recombinant mammalian cell cultures to prevent cell aggregation, thereby increasing…”
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High-throughput screening discovers antifibrotic properties of haloperidol by hindering myofibroblast activation by Rehman, Michael, Vodret, Simone, Braga, Luca, Guarnaccia, Corrado, Celsi, Fulvio, Rossetti, Giulia, Martinelli, Valentina, Battini, Tiziana, Long, Carlin, Vukusic, Kristina, Kocijan, Tea, Collesi, Chiara, Ring, Nadja, Skoko, Natasa, Giacca, Mauro, Del Sal, Giannino, Confalonieri, Marco, Raspa, Marcello, Marcello, Alessandro, Myers, Michael P, Crovella, Sergio, Carloni, Paolo, Zacchigna, Serena

“…Fibrosis is a hallmark in the pathogenesis of various diseases, with very limited therapeutic solutions. A key event in the fibrotic process is the expression…”
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Dual Role of Dextran Sulfate 5000 Da as Anti-Apoptotic and Pro-Autophagy Agent by Menvielle, J. Pedro, Safini, Najete, Tisminetzky, Sergio G, Skoko, Natasa

“…Dextran sulfate 5,000 Da (DS), a sulfated polysaccharide, has been used in recombinant mammalian cell cultures to prevent cell aggregation, thereby increasing…”
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