Search Results - "Skett, P"

Inhibition of metallo-beta-lactamases by a series of mercaptoacetic acid thiol ester derivatives by PAYNE, D. J, BATESON, J. H, REID, R, GHOSEZ, L, COMBRET, Y, MARCHAND-BRYNAERT, J, GASSON, B. C, PROCTOR, D, KHUSHI, T, FARMER, T. H, TOLSON, D. A, BELL, D, SKETT, P. W, MARSHALL, A. C

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A by Al-Habori, M, Raman, A, Lawrence, M J, Skett, P

“…Fenugreek (Trigonella foenum-graecum L. seed) is a food with traditional medicinal use in diabetes. Beneficial effects have been demonstrated in diabetic…”
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Maintenance of steroid metabolism and hormone responsiveness in cryopreserved dog, monkey and human hepatocytes by Skett, P, Roberts, P, Khan, S

“…The efficient and effective use of hepatocytes from larger species and rare human material requires a reliable storage method for cells not needed on the day…”
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SB-203207 and SB-203208, two novel isoleucyl tRNA synthetase inhibitors from a Streptomyces sp. II. Structure determination by Houge-Frydrych, C S, Gilpin, M L, Skett, P W, Tyler, J W

“…Two novel isoleucyl tRNA synthetase inhibitors, SB-203207 and SB-203208 have been isolated from a Streptomyces sp. and found to be structurally related to…”
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Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics by FORRESTER, L. M, HENDERSON, C. J, WOLF, C. R, GLANCEY, M. J, BACK, D. J, PARK, B. K, BALL, S. E, KITTERINGHAM, N. R, MCLAREN, A. W, MILES, J. S, SKETT, P

“…Cytochrome P450s play a central role in the metabolism and disposition of an extremely wide range of drugs and chemical carcinogens. Individual differences in…”
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Sex steroid induced changes in hepatic enzymes by Gustafsson, J A, Mode, A, Norstedt, G, Skett, P

“…Sex differences exist in steroid and xenobiotic metabolism in the liver of a number of species. In the rat, the differences are regulated through the…”
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Role of hormones in the control of mixed-function oxidases by Skett, P

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Changes in adenosine sensitivity in the hippocampus of rats with streptozotocin‐induced diabetes by Morrison, P.D, Mackinnon, M.W.B., Bartrup, J.T., Skett, P.G., Stone, T.W.

“…1 Hippocampal slices have been used to assess the sensitivity of the CNS to adenosine and γ‐aminobutyric acid (GABA) in diabetes. The effects of adenosine,…”
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Sex-dependent effect of streptozotocin-induced diabetes mellitus on hepatic steroid metabolism in the rat by Skett, P

“…Diabetes mellitus is known to affect drug and steroid metabolism in the rat liver. Recently it has been shown that the effect on drug metabolism is both…”
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Report on the International Workshop on the Use of Human In Vitro Liver Preparations to Study Drug Metabolism in Drug Development by Skett, Paul, Tyson, Charles, Guillouzo, André, Maier, Peter

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The time course of the effect of hypophysectomy and oestrogen treatment on the hepatic metabolism of androst-4-ene-3,17-dione in male and female rats by Skett, P

“…Hypophysectomy of male animals has little effect on the hepatic androst-4-ene,3,17-dione (androstenedione) metabolism, except for possible changes in the…”
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Maintenance of liver-specific function in cultured hepatocytes in different media by Khan, S, Paxton, J, Roberts, P, Skett, P

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Mechanism of action of cyclic AMP in altering steroid metabolism in permeabilized rat hepatocytes by Berry, L A, Skett, P

“…The effects of various concentrations of cyclic AMP (cAMP) on the metabolism of androst-4-ene-3,17-dione were examined in electropermeabilized rat hepatocytes…”
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Effect of phorbol esters and diacylglycerol on steroid metabolism in isolated rat hepatocytes by Allan, C J, Skett, P

“…Hepatocytes, isolated from adult male rats and maintained in serum- and hormone-free medium, were pretreated with phorbol esters known to activate protein…”
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Endocrine regulation of the metabolism of 1-naphthol in the rat by Graham, D L, Skett, P

“…A sex difference exists in the rate of conjugation of 1-naphthol by rat liver cubes with the male exhibiting a more than 3-fold higher activity (1.69 +/- 0.20…”
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The role of microsomal phospholipids and their fatty acid composition in the control of hepatic metabolism of lignocaine by Meftah, Nuri Musa, Skett, Paul

“…1 Sex differences exist in the metabolism of lignocaine by the rat liver. Microsomal phospholipids have been implicated in the control of these sex…”
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Time course of the effect of streptozotocin on serum concentration of glucose and triglycerides and on hepatic drug metabolism in the male rat by MacFarlane, M, Skett, P

“…Streptozotocin (STZ) causes a rise in serum glucose, triglycerides and ketones and a fall in insulin and also leads to changes in drug metabolism. Results from…”
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The effects of pituitary hormones on hepatic drug metabolism in the rat by Skett, P, Young, C

“…Sex differences exist in the hepatic microsomal metabolism of drugs in the rat. These differences have been shown to be related to the presence of androgen in…”
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Influence of a Novel Hypophyseal Factor on Steroid Metabolism in Cultured Hepatoma Cells by Gustafsson, Jan-Ake, Larsson, Agne, Skett, Paul, Stenberg, Ake

“…A rat hepatoma cell line in tissue culture (HTC cells) was treated with hypophyseal extracts from adult male and female rats. Cell homogenates were then…”
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Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel by Li, Albert P., Gorycki, Peter D., Hengstler, Jan G., Kedderis, Gregory L., Koebe, Hans G., Rahmani, Roger, de Sousas, Georges, Silva, Jose M., Skett, Paul

“…Successful cryopreservation of freshly isolated hepatocytes would significantly decrease the need for freshly-procured livers for the preparation of…”
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