Search Results - "Skelton, Andrew J"

Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant by Shepherd, Colin, Zhu, Dongxing, Skelton, Andrew J., Combe, Jennifer, Threadgold, Harrison, Zhu, Linyi, Vincent, Tonia L., Stuart, Paul, Reynard, Louise N., Loughlin, John

“…Objective To identify the functional single‐nucleotide polymorphisms (SNPs) and mechanisms conferring increased risk of hand osteoarthritis (OA) at the ALDH1A2…”
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Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study by Baker, Kenneth F., Skelton, Andrew J., Lendrem, Dennis W., Scadeng, Adam, Thompson, Ben, Pratt, Arthur G., Isaacs, John D.

“…Many patients with rheumatoid arthritis (RA) achieve disease remission with modern treatment strategies. However, having achieved this state, there are no…”
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Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts by Williams, Rachel C, Skelton, Andrew J, Todryk, Stephen M, Rowan, Andrew D, Preshaw, Philip M, Taylor, John J

“…Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response…”
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DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation by Gómez, Rodolfo, Barter, Matt J, Alonso-Pérez, Ana, Skelton, Andrew J, Proctor, Carole, Herrero-Beaumont, Gabriel, Young, David A

“…Knowledge about regulating transcription factors (TFs) for osteoblastogenesis from mesenchymal stem cells (MSCs) is limited. Therefore, we investigated the…”
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Signal transducer and activator of transcription 5B deficiency due to a novel missense mutation in the coiled-coil domain by Acres, Meghan J., Gothe, Florian, Grainger, Angela, Skelton, Andrew J., Swan, David J., Willet, Joseph D.P., Leech, Suzy, Galcheva, Sonya, Iotova, Violeta, Hambleton, Sophie, Engelhardt, Karin R.

“…Compared with 3 controls, the patient showed reduced STAT5 phosphorylation (Fig 2, E). Because the antibody used recognizes phosphorylated STAT5A and STAT5B,…”
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IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function by Ridgley, Laura A, Anderson, Amy E, Maney, Nicola J, Naamane, Najib, Skelton, Andrew J, Lawson, Catherine A, Emery, Paul, Isaacs, John D, Carmody, Ruaidhrí J, Pratt, Arthur G

“…We have previously shown that increased circulating interleukin-6 (IL-6) results in enhanced CD4+ T cell signaling via signal transduction and activator of…”
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Early-onset autoimmune disease due to a heterozygous loss-of-function mutation in TNFAIP3 (A20) by Duncan, Christopher J A, Dinnigan, Emma, Theobald, Rachel, Grainger, Angela, Skelton, Andrew J, Hussain, Rafiqul, Willet, Joseph D P, Swan, David J, Coxhead, Jonathan, Thomas, Matthew F, Thomas, Julian, Zamvar, Veena, Slatter, Mary A, Cant, Andrew J, Engelhardt, Karin R, Hambleton, Sophie

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The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells by Barter, Matt J, Gomez, Rodolfo, Hyatt, Sam, Cheung, Kat, Skelton, Andrew J, Xu, Yaobo, Clark, Ian M, Young, David A

“…Long non-coding RNAs (lncRNAs) are expressed in a highly tissue-specific manner and function in various aspects of cell biology, often as key regulators of…”
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Prioritization of PLEC and GRINA as Osteoarthritis Risk Genes Through the Identification and Characterization of Novel Methylation Quantitative Trait Loci by Rice, Sarah J., Tselepi, Maria, Sorial, Antony K., Aubourg, Guillaume, Shepherd, Colin, Almarza, David, Skelton, Andrew J., Pangou, Ioanna, Deehan, David, Reynard, Louise N., Loughlin, John

“…Objective To identify methylation quantitative trait loci (mQTLs) correlating with osteoarthritis (OA) risk alleles and to undertake mechanistic…”
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Human IFNAR2 deficiency: Lessons for antiviral immunity by Duncan, Christopher J A, Mohamad, Siti M B, Young, Dan F, Skelton, Andrew J, Leahy, T Ronan, Munday, Diane C, Butler, Karina M, Morfopoulou, Sofia, Brown, Julianne R, Hubank, Mike, Connell, Jeff, Gavin, Patrick J, McMahon, Cathy, Dempsey, Eugene, Lynch, Niamh E, Jacques, Thomas S, Valappil, Manoj, Cant, Andrew J, Breuer, Judith, Engelhardt, Karin R, Randall, Richard E, Hambleton, Sophie

“…Type I interferon (IFN-α/β) is a fundamental antiviral defense mechanism. Mouse models have been pivotal to understanding the role of IFN-α/β in immunity,…”
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CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis: Implications for Causal Gene Identification by Thalayasingam, Nishanthi, Nair, Nisha, Skelton, Andrew J, Massey, Jonathan, Anderson, Amy E, Clark, Alexander D, Diboll, Julie, Lendrem, Dennis W, Reynard, Louise N, Cordell, Heather J, Eyre, Stephen, Isaacs, John D, Barton, Anne, Pratt, Arthur G

“…Rheumatoid arthritis (RA) is a genetically complex disease of immune dysregulation. This study sought to gain further insight into the genetic risk mechanisms…”
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Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci by Clark, Alexander D., Nair, Nisha, Anderson, Amy E., Thalayasingam, Nishanthi, Naamane, Najib, Skelton, Andrew J., Diboll, Julie, Barton, Anne, Eyre, Stephen, Isaacs, John D., Pratt, Arthur G., Reynard, Louise N.

“…Defining regulatory mechanisms through which noncoding risk variants influence the cell-mediated pathogenesis of immune-mediated disease (IMD) has emerged as a…”
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Regulation of microRNA‐221, ‐222, ‐21 and ‐27 in articular cartilage subjected to abnormal compressive forces by Stadnik, Paulina S., Gilbert, Sophie J., Tarn, Jessica, Charlton, Sarah, Skelton, Andrew J., Barter, Matthew J., Duance, Victor C., Young, David A., Blain, Emma J.

“…Key points microRNAs (miRs) are small non‐coding molecules that regulate post‐transcriptional target gene expression. miRs are involved in regulating cellular…”
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Erratum to "Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study" [J. Autoimmun. 105 (December 2019) 102298] by Baker, Kenneth F, Skelton, Andrew J, Lendrem, Dennis W, Scadeng, Adam, Thompson, Ben, Pratt, Arthur G, Isaacs, John D

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microRNA-seq of cartilage reveals an overabundance of miR-140-3p which contains functional isomiRs by Woods, Steven, Charlton, Sarah, Cheung, Kat, Hao, Yao, Soul, Jamie, Reynard, Louise N, Crowe, Natalie, Swingler, Tracey E, Skelton, Andrew J, Piróg, Katarzyna A, Miles, Colin G, Tsompani, Dimitra, Jackson, Robert M, Dalmay, Tamas, Clark, Ian M, Barter, Matt J, Young, David A

“…miR-140 is selectively expressed in cartilage. Deletion of the entire locus in mice results in growth retardation and early-onset osteoarthritis-like…”
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DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions by Barter, Matt J., Bui, Catherine, Cheung, Kathleen, Falk, Julia, Gómez, Rodolfo, Skelton, Andrew J., Elliott, Hannah R., Reynard, Louise N., Young, David A.

“…Regulation of transcription occurs in a cell type specific manner orchestrated by epigenetic mechanisms including DNA methylation. Methylation changes may also…”
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Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis by Anderson, Amy E, Maney, Nicola J, Nair, Nisha, Lendrem, Dennis W, Skelton, Andrew J, Diboll, Julie, Brown, Philip M, Smith, Graham R, Carmody, Ruaidhrí J, Barton, Anne, Isaacs, John D, Pratt, Arthur G

“…Abstract Objectives Dysregulated signal transduction and activator of transcription-3 (STAT3) signalling in CD4+ T cells has been proposed as an early…”
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Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2 by Duncan, Christopher J A, Thompson, Benjamin J, Chen, Rui, Rice, Gillian I, Gothe, Florian, Young, Dan F, Lovell, Simon C, Shuttleworth, Victoria G, Brocklebank, Vicky, Corner, Bronte, Skelton, Andrew J, Bondet, Vincent, Coxhead, Jonathan, Duffy, Darragh, Fourrage, Cecile, Livingston, John H, Pavaine, Julija, Cheesman, Edmund, Bitetti, Stephania, Grainger, Angela, Acres, Meghan, Innes, Barbara A, Mikulasova, Aneta, Sun, Ruyue, Hussain, Rafiqul, Wright, Ronnie, Wynn, Robert, Zarhrate, Mohammed, Zeef, Leo A H, Wood, Katrina, Hughes, Stephen M, Harris, Claire L, Engelhardt, Karin R, Crow, Yanick J, Randall, Richard E, Kavanagh, David, Hambleton, Sophie, Briggs, Tracy A

“…Excessive type I interferon (IFNα/β) activity is implicated in a spectrum of human disease, yet its direct role remains to be conclusively proven. We…”
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Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874 by Shepherd, Colin, Skelton, Andrew J, Rushton, Michael D, Reynard, Louise N, Loughlin, John

“…Osteoarthritis (OA) is a painful, debilitating disease characterised by loss of articular cartilage with concurrent changes in other tissues of the synovial…”
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CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis by Thalayasingam, Nishanthi, Nair, Nisha, Skelton, Andrew J., Massey, Jonathan, Anderson, Amy E., Clark, Alexander D., Diboll, Julie, Lendrem, Dennis W., Reynard, Louise N., Cordell, Heather J., Eyre, Stephen, Isaacs, John D., Barton, Anne, Pratt, Arthur G.

“…Objective Rheumatoid arthritis (RA) is a genetically complex disease of immune dysregulation. This study sought to gain further insight into the genetic risk…”
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