Search Results - "Skelly, Donal"

A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1β, [corrected] TNF-α and IL-6 challenges in C57BL/6 mice by Skelly, Donal T, Hennessy, Edel, Dansereau, Marc-Andre, Cunningham, Colm

“…It is increasingly clear that systemic inflammation has both adaptive and deleterious effects on the brain. However, detailed comparisons of brain effects of…”
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Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms by Skelly, Donal T., Griffin, Éadaoin W., Murray, Carol L., Harney, Sarah, O’Boyle, Conor, Hennessy, Edel, Dansereau, Marc-Andre, Nazmi, Arshed, Tortorelli, Lucas, Rawlins, J. Nicholas, Bannerman, David M., Cunningham, Colm

“…Systemic inflammation can impair cognition with relevance to dementia, delirium and post-operative cognitive dysfunction. Episodes of delirium also contribute…”
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Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6 by Murray, Carol L, Skelly, Donal T, Cunningham, Colm

“…Chronic neurodegeneration comprises an inflammatory response but its contribution to the progression of disease remains unclear. We have previously shown that…”
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2 cases of idiopathic immune reconstitution-related demyelination following rituximab treatment by Donal, Skelly, David, Jakabek, Camilla, Buckley, Pieter, Pretorius, Sarosh, Irani, Isabel, Leite

“…We describe 2 cases of acute demyelination in the context of immune reconstitution, following rituximab. CSF studies were negative for JC virus, and common…”
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Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction by Griffin, Éadaoin W, Skelly, Donal T, Murray, Carol L, Cunningham, Colm

“…Systemic inflammatory events often precipitate acute cognitive dysfunction in elderly and demented populations. Delirium is a highly prevalent neuropsychiatric…”
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Worsening Cognitive Impairment and Neurodegenerative Pathology Progressively Increase Risk for Delirium by Davis, Daniel H.J., M.R.C.P., Ph.D, Skelly, Donal T., Ph.D, Murray, Carol, M.Sc, Hennessy, Edel, B.A, Bowen, Jordan, M.B., B.S, Norton, Samuel, Ph.D, Brayne, Carol, M.D, Rahkonen, Terhi, M.D, Sulkava, Raimo, M.D, Sanderson, David J., Ph.D, Rawlins, J. Nicholas, Ph.D, Bannerman, David M., Ph.D, MacLullich, Alasdair M.J., M.R.C.P., Ph.D, Cunningham, Colm, Ph.D

“…Background Delirium is a profound neuropsychiatric disturbance precipitated by acute illness. Although dementia is the major risk factor this has typically…”
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A Novel Immunofluorescence Assay for the Rapid Serological Detection of SARS-CoV-2 Infection by Nguyen, Dung, Skelly, Donal, Goonawardane, Niluka

“…As of April 2021, the COVID-19 pandemic has swept through 213 countries and infected more than 132 million individuals globally, posing an unprecedented threat…”
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Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age by McGarry, Niamh, Murray, Carol L., Garvey, Sean, Wilkinson, Abigail, Tortorelli, Lucas, Ryan, Lucy, Hayden, Lorna, Healy, Daire, Griffin, Eadaoin W., Hennessy, Edel, Arumugam, Malathy, Skelly, Donal T., Mitchell, Kevin J., Cunningham, Colm

“…•The innate immune response to poly I:C is determined by double stranded RNA length.•Blood IFN-I, induced by high MW poly I:C, is necessary for CNS…”
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Correction: A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice by Skelly, Donal T., Hennessy, Edel, Dansereau, Marc-Andre, Cunningham, Colm

“…The greek symbol beta in IL-1β was incorrectly substituted with the letter B. The correct title is: A Systematic Analysis of the Peripheral and CNS Effects of…”
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Cellular immunity to SARS-CoV-2 following intrafamilial exposure in seronegative family members by Jay, Cecilia, Adland, Emily, Csala, Anna, Dold, Christina, Edmans, Matthew, Hackstein, Carl-Philipp, Jamsen, Anni, Lim, Nicholas, Longet, Stephanie, Ogbe, Ane, Sampson, Oliver, Skelly, Donal, Spiller, Owen B, Stafford, Lizzie, Thompson, Craig P, Turtle, Lance, Barnes, Ellie, Dunachie, Susanna, Carroll, Miles, Klenerman, Paul, Conlon, Chris, Goulder, Philip, Jones, Lucy C

“…Family studies of antiviral immunity provide an opportunity to assess virus-specific immunity in infected and highly exposed individuals, as well as to examine…”
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Correction: Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms by Skelly, Donal T., Griffin, Éadaoin W., Murray, Carol L., Harney, Sarah, O’Boyle, Conor, Hennessy, Edel, Dansereau, Marc-Andre, Nazmi, Arshed, Tortorelli, Lucas, Rawlins, J. Nicholas, Bannerman, David M., Cunningham, Colm

“…Following publication of this article, the authors noticed an error in the abstract, where they incorrectly stated that: “Direct application of IL-1β to ex…”
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The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants by Liu, Chang, Zhou, Daming, Nutalai, Rungtiwa, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Ginn, Helen M., Dejnirattisai, Wanwisa, Supasa, Piyada, Mentzer, Alexander J., Wang, Beibei, Case, James Brett, Zhao, Yuguang, Skelly, Donal T., Chen, Rita E., Johnson, Sile Ann, Ritter, Thomas G., Mason, Chris, Malik, Tariq, Temperton, Nigel, Paterson, Neil G., Williams, Mark A., Hall, David R., Clare, Daniel K., Howe, Andrew, Goulder, Philip J.R., Fry, Elizabeth E., Diamond, Michael S., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Alpha-B.1.1.7, Beta-B.1.351, Gamma-P.1, and Delta-B.1.617.2 variants of SARS-CoV-2 express multiple mutations in the spike protein (S). These may alter the…”
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Non-Steroidal Anti-Inflammatory Drugs and Cognitive Function: Are Prostaglandins at the Heart of Cognitive Impairment in Dementia and Delirium ? by Cunningham, Colm, Skelly, Donal Thomas

“…Studies of non-steroidal anti-inflammatory drugs (NSAIDs) in rheumatoid arthritis imply that inflammation is important in the development of Alzheimer’s…”
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Implementation and Extended Evaluation of the Euroimmun Anti-SARS-CoV-2 IgG Assay and Its Contribution to the United Kingdom's COVID-19 Public Health Response by Otter, Ashley David, Bown, Abbie, D'Arcangelo, Silvia, Bailey, Daniel, Semper, Amanda, Hewson, Jacqueline, Catton, Matthew, Perumal, Prem, Sweed, Angela, McKee, Deborah Fox, Jones, Jessica, Harvala, Heli, Lamikanra, Abigail, Zambon, Maria, Andrews, Nick, Whitaker, Heather, Linley, Ezra, Mentzer, Alexander J, Skelly, Donal, Knight, Julian C, Klenerman, Paul, Amirthalingam, Gayatri, Taylor, Stephen, Rowe, Cathy, Vipond, Richard, Brooks, Tim

“…In March 2020, the Rare and Imported Pathogens Laboratory at the UK Health Security Agency (UKHSA) (formerly Public Health England [PHE]) Porton Down, was…”
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Evaluation of QuantiFERON SARS-CoV-2 interferon-γ release assay following SARS-CoV-2 infection and vaccination by Johnson, Síle A, Phillips, Eloise, Adele, Sandra, Longet, Stephanie, Malone, Tom, Mason, Chris, Stafford, Lizzie, Jamsen, Anni, Gardiner, Siobhan, Deeks, Alexandra, Neo, Janice, Blurton, Emily J, White, Jemima, Ali, Muhammed, Kronsteiner, Barbara, Wilson, Joseph D, Skelly, Dónal T, Jeffery, Katie, Conlon, Christopher P, Goulder, Philip, Consortium, PITCH, Carroll, Miles, Barnes, Eleanor, Klenerman, Paul, Dunachie, Susanna J

“…Abstract T cells are important in preventing severe disease from SARS-CoV-2, but scalable and field-adaptable alternatives to expert T-cell assays are needed…”
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Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum by Tuekprakhon, Aekkachai, Huo, Jiandong, Nutalai, Rungtiwa, Dijokaite-Guraliuc, Aiste, Zhou, Daming, Ginn, Helen M., Selvaraj, Muneeswaran, Liu, Chang, Mentzer, Alexander J., Supasa, Piyada, Duyvesteyn, Helen M.E., Das, Raksha, Skelly, Donal, Ritter, Thomas G., Amini, Ali, Bibi, Sagida, Adele, Sandra, Johnson, Sile Ann, Constantinides, Bede, Webster, Hermione, Temperton, Nigel, Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Crook, Derrick, Pollard, Andrew J., Lambe, Teresa, Goulder, Philip, Paterson, Neil G., Williams, Mark A., Hall, David R., Conlon, Christopher, Deeks, Alexandra, Frater, John, Frending, Lisa, Gardiner, Siobhan, Jämsén, Anni, Jeffery, Katie, Malone, Tom, Phillips, Eloise, Rothwell, Lucy, Stafford, Lizzie, Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…The Omicron lineage of SARS-CoV-2, first described in November 2021, spread rapidly to become globally dominant and has split into a number of sub-lineages…”
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Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera by Zhou, Daming, Dejnirattisai, Wanwisa, Supasa, Piyada, Liu, Chang, Mentzer, Alexander J., Ginn, Helen M., Zhao, Yuguang, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Wang, Beibei, Paesen, Guido C., Lopez-Camacho, Cesar, Slon-Campos, Jose, Hallis, Bassam, Coombes, Naomi, Bewley, Kevin, Charlton, Sue, Walter, Thomas S., Skelly, Donal, Lumley, Sheila F., Dold, Christina, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah, James, William, Carroll, Miles W., Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…The race to produce vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began when the first sequence was published, and this forms…”
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Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum by Liu, Chang, Ginn, Helen M., Dejnirattisai, Wanwisa, Supasa, Piyada, Wang, Beibei, Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Zhou, Daming, Mentzer, Alexander J., Zhao, Yuguang, Duyvesteyn, Helen M.E., López-Camacho, César, Slon-Campos, Jose, Walter, Thomas S., Skelly, Donal, Johnson, Sile Ann, Ritter, Thomas G., Mason, Chris, Costa Clemens, Sue Ann, Gomes Naveca, Felipe, Nascimento, Valdinete, Nascimento, Fernanda, Fernandes da Costa, Cristiano, Resende, Paola Cristina, Pauvolid-Correa, Alex, Siqueira, Marilda M., Dold, Christina, Temperton, Nigel, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah C., Malik, Tariq, Carroll, Miles W., Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Baillie, Vicky, Serafin, Natali, Ditse, Zanele, Da Silva, Kelly, Paterson, Neil G., Williams, Mark A., Hall, David R., Madhi, Shabir, Nunes, Marta C., Goulder, Philip, Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant…”
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Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera by Supasa, Piyada, Zhou, Daming, Dejnirattisai, Wanwisa, Liu, Chang, Mentzer, Alexander J., Ginn, Helen M., Zhao, Yuguang, Duyvesteyn, Helen M.E., Nutalai, Rungtiwa, Tuekprakhon, Aekkachai, Wang, Beibei, Paesen, Guido C., Slon-Campos, Jose, López-Camacho, César, Hallis, Bassam, Coombes, Naomi, Bewley, Kevin R., Charlton, Sue, Walter, Thomas S., Barnes, Eleanor, Dunachie, Susanna J., Skelly, Donal, Lumley, Sheila F., Baker, Natalie, Shaik, Imam, Humphries, Holly E., Godwin, Kerry, Gent, Nick, Sienkiewicz, Alex, Dold, Christina, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Klenerman, Paul, Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah, Hall, David R., Williams, Mark A., Paterson, Neil G., James, William, Carroll, Miles W., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike…”
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The antigenic anatomy of SARS-CoV-2 receptor binding domain by Dejnirattisai, Wanwisa, Zhou, Daming, Ginn, Helen M., Duyvesteyn, Helen M.E., Supasa, Piyada, Case, James Brett, Zhao, Yuguang, Walter, Thomas S., Mentzer, Alexander J., Liu, Chang, Wang, Beibei, Paesen, Guido C., Slon-Campos, Jose, López-Camacho, César, Kafai, Natasha M., Bailey, Adam L., Chen, Rita E., Ying, Baoling, Thompson, Craig, Bolton, Jai, Fyfe, Alex, Gupta, Sunetra, Tan, Tiong Kit, Gilbert-Jaramillo, Javier, James, William, Knight, Michael, Carroll, Miles W., Skelly, Donal, Dold, Christina, Peng, Yanchun, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Klenerman, Paul, Temperton, Nigel, Hall, David R., Williams, Mark A., Paterson, Neil G., Bertram, Felicity K.R., Siebert, C. Alistair, Clare, Daniel K., Howe, Andrew, Radecke, Julika, Song, Yun, Townsend, Alain R., Huang, Kuan-Ying A., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Diamond, Michael S., Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency use as therapeutics. Here, we identify 377 human monoclonal antibodies…”
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