Search Results - "Skellern, G G"

The individual components of commercial isometamidium do not possess stronger trypanocidal activity than the mixture, nor bypass isometamidium resistance by Eze, Anthonius A., Igoli, John, Gray, Alexander I., Skellern, Graham G., De Koning, Harry P.

“…The four components present in the trypanocidal treatment Samorin, the commercially available formulation of isometamidium, were separated and purified by…”
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Animal trypanosomosis: making quality control of trypanocidal drugs possible by Sutcliffe, O B, Skellern, G G, Araya, F, Cannavan, A, Sasanya, J J, Dungu, B, van Gool, F, Münstermann, S, Mattioli, R C

“…African animal trypanosomosis is arguably the most important animal disease impairing livestock agricultural development in sub-Saharan Africa. In addition to…”
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Metabolism of the dihydropyridine calcium channel blockers mebudipine and dibudipine by isolated rat hepatocytes by Bohlooli, S., Mahmoudian, M., Skellern, G. G., Grant, M. H., Tettey, J. N. A.

“…The prototype 1,4‐dihydropyridine (1,4‐DHP) nifedipine, indicated for the management of hypertension and angina pectoris, has drawbacks of rapid onset of…”
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Distamycin Analogues with Enhanced Lipophilicity:  Synthesis and Antimicrobial Activity by Khalaf, Abedawn I., Waigh, Roger D., Drummond, Allan J., Pringle, Breffni, McGroarty, Ian, Skellern, Graham G., Suckling, Colin J.

“…Forty-eight heterocyclic amino acid trimers, analogues of distamycin, with a number of features that enhance lipophilicity are described. They contain alkyl or…”
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Proton and Oxide Ion Conductivity in Palmierite Oxides by Fop, Sacha, Dawson, James A., Tawse, Dylan N., Skellern, Matthew G., Skakle, Janet M. S., Mclaughlin, Abbie C.

“…Solid proton and oxide ion conductors have key applications in several hydrogen-based and energy-related technologies. Here, we report on the discovery of…”
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Quantification of binding data using capillary electrophoresis by Araya, Fitsumbirhan, Skellern, Graham G, Waigh, Roger D

“…The design of new DNA-targeted molecules, primarily for use in the therapy of diseases such as cancer, relies on the assessment of both affinity for DNA and…”
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Development of a liquid chromatography–mass spectrometric method for measuring the binding of memantine to different melanins by Koeberle, Martin J, Hughes, Patrick M, Wilson, Clive G, Skellern, Graham G

“…A sensitive and selective liquid chromatography–mass spectrometric method was validated for the determination of free memantine in melanin binding studies. The…”
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Two very unusual macrocyclic flavonoids from the water lily Nymphaea lotus by Elegami, Awatif A., Bates, Catharine, Gray, Alexander I., Mackay, Simon P., Skellern, Graham G., Waigh, Roger D.

“…Three novel flavonols, myricetin-3′-O-(6″-p-coumaroyl)glucoside and two epimeric macrocyclic derivatives, as well as the known myricetin-3-O-rhamnoside and…”
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Determination of diminazene aceturate in pharmaceutical formulations by HPLC and identification of related substances by LC/MS by Atsriku, C, Watson, D.G, Tettey, J.N.A, Grant, M.H, Skellern, G.G

“…A validated, reversed-phase, isocratic high-performance liquid chromatographic method for the simultaneous assay of diminazene aceturate, antipyrine…”
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Capillary electrochromatography of therapeutic peptides on mixed-mode butylmethacrylate monoliths by Adu, Joseph K., Lau, Simon S., Watson, David G., Euerby, Melvin R., Skellern, Graham G., Tettey, Justice N. A.

“…In this study, a porous mixed‐mode n‐alkyl methacrylate‐based monolith has been used in the separation of therapeutic peptides. While the sulfonic acid (SCX)…”
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Control of impurities in diphenhydramine hydrochloride by an ion-pairing, reverse-phase liquid chromatographic method by Henderson, L., Miller, J. H. McB, Skellern, G. G.

“…A precise, sensitive, repeatable and robust reverse‐phase liquid chromatographic method has been developed for the control of seven possible impurities of…”
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Acceptance criteria for levels of hydrazine in substances for pharmaceutical use and analytical methods for its determination by Kean, T, Miller, J H McB, Skellern, G G, Snodin, D

“…This report includes a brief review of the toxicology of hydrazine and the strategies used to set acceptance criteria. A preliminary examination of a number of…”
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Use of capillary electrophoresis in the study of ligand-DNA interactions by Hamdan, Imad I, Skellern, Graham G, Waigh, Roger D

“…Free solution capillary electrophoresis (FSCE) has been used to separate two non-self-complementary 12mer oligonucleotide duplexes:…”
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Binding of memantine to melanin: Influence of type of melanin and characteristics by KOEBERLE, Martin J, HUGHES, Patrick M, SKELLERN, Graham G, WILSON, Clive G

“…The objectives of this study were to characterize sepia, synthetic, and bovine melanin and to determine their binding characteristics to the drug memantine…”
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Metabolism and distribution of phenanthridine trypanocides in Trypanosoma brucei by Boibessot, I, Turner, C.M.R, Watson, D.G, Goldie, E, Connel, G, McIntosh, A, Grant, M.H, Skellern, G.G

“…Phenanthridine trypanocides (isometamidium chloride hydrochloride, ISM, and Ethidium bromide, EBr) have been widely used to treat African trypanosomiasis in…”
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The compatibility and stability of octreotide acetate in the presence of diamorphine hydrochloride in polypropylene syringes by Fielding, H, Kyaterekera, N, Skellern, G G, Tettey, J N, McDade, J R, Msuya, Z, Watson, D G, Urie, J

“…Varying concentrations of octreotide acetate (Sandostatin®) and diamorphine hydrochloride were prepared and stored in polypropylene syringes at 37°C in the…”
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A tungsten oxide-based photoelectrocatalyst for degradation of environmental contaminants by Macphee, Donald E., Rosenberg, Daniel, Skellern, Matt G., Wells, Richard P., Duffy, John A., Killham, Kenneth S.

“…The use of photocatalysts in the remediation of contaminated water is now well established in the scientific literature, the most common photocatalyst being…”
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DNA binding of a short lexitropsin by ANTHONY, Nahoum G, FOX, Keith R, JOHNSTON, Blair F, KHALAF, Abedawn I, MACKAY, Simon P, MCGROARTY, Lain S, PARKINSON, John A, SKELLERN, Graham G, SUCKLING, Colin J, WAIGH, Roger D

“…Footprinting, capillary electrophoresis, molecular modelling and NMR studies have been used to examine the binding of a short polyamide to DNA. This molecule,…”
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Migration behavior of weakly retained, charged analytes in voltage-assisted micro-high performance liquid chromatography by Channer, Barbara, Skellern, Graham G., Euerby, Melvin R., McKeown, Alan P., Rathore, Anurag S.

“…The application of voltage in micro-high performance liquid chromatography (micro-HPLC) creates a system where separation is governed by a hybrid differential…”
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Comparative biotransformation of morphine, codeine and pholcodine in rat hepatocytes: identification of a novel metabolite of pholcodine by Jairaj, M., Watson, D. G., Grant, M. H., Gray, A. I., Skellern, G. G.

“…1. Pholcodine (3-morpholinoethylmorphine), a semi-synthetic alkaloid, is widely used as an antitussive agent. 2. Norpholcodine [7,8-didehydro-4,5 α…”
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