Search Results - "Skeean, Richard"

Lewis acid and photochemically mediated cyclization of olefinic .beta.-keto esters by White, James D, Skeean, Richard W, Trammell, Gary L

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Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate by Repine, Joseph T, Himmelsbach, Richard J, Hodges, John C, Kaltenbronn, James S, Sircar, Ila, Skeean, Richard W, Brennan, Sean T, Hurley, Timothy R, Lunney, Elizabeth

“…A series of renin inhibitors containing ester side chains at the P2 subsite are potent inhibitors of primate renin. Derivatives containing the diol isostere…”
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Stereoselective, biogenetically patterned synthesis of (.+-.)-aplysistatin by White, James D, Nishiguchi, Takeshi, Skeean, Richard W

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Cardiotonic agents. 6. Synthesis and inotropic activity of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones: ring-contracted analogs of imazodan (CI-914) by Sircar, Ila, Morrison, Glenn C, Burke, Sandra E, Skeean, Richard, Weishaar, Ronald E

“…A series of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones was synthesized and evaluated for positive inotropic activity. Only compounds with two…”
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Photochemistry of enolate anions. Anion-directed photochemical cyclization of a dienone by White, James D, Skeean, Richard W

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Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid: preparation and biological activity by Culbertson, Townley P, Domagala, John M, Nichols, Jeffery B, Priebe, Stephen, Skeean, Richard W

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Development of a Scalable Process for CI-1034, an Endothelin Antagonist by Jacks, Thomas E, Belmont, Daniel T, Briggs, Christopher A, Horne, Nicole M, Kanter, Gerald D, Karrick, Greg L, Krikke, James J, McCabe, Richard J, Mustakis, Jason G, Nanninga, Thomas N, Risedorph, Guy S, Seamans, Ronald E, Skeean, Richard, Winkle, Derick D, Zennie, Thomas M

“…A concise, convergent multikilogram synthesis of CI-1034 (1), a potent endothelin receptor antagonist, is described. A 15-step preparation from commercially…”
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Ac-[3- and 4-Alkylthioproline31]-CCK4 Analogs: Synthesis and Implications for the CCK-B Receptor-Bound Conformation by Kolodziej, Stephen A, Nikiforovich, Gregory V, Skeean, Richard, Lignon, Marie-Francoise, Martinez, Jean, Marshall, Garland R

“…It has been reported that substitution of the Met31 residue in Boc-CCK4 (Boc-Trp30-Met31-Asp32-Phe33-NH2, CCK33 numbering) by trans-3-propyl-L-proline yields a…”
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Multiple binding modes for the receptor-bound conformations of cyclic AII agonists by Plucinska, Krystina, Kataoka, Takahiro, Yodo, Mitsuaki, Cody, Wayne L, He, J. X, Humblet, Christine, Lu, G. H, Lunney, Elizabeth, Major, Terry C

“…Angiotensin II, Asp-Arg-Val-Tyr-His-Pro-Phe, binds its receptor with a postulated turn centered at residue four. Analogs of angiotensin II which contain a…”
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Bradykinin and angiotensin II analogs containing a conformationally constrained proline analog by Juvvadi, P, Dooley, D J, Humblet, C C, Lu, G H, Lunney, E A, Panek, R L, Skeean, R, Marshall, G R

“…Three analogs of bradykinin and one of angiotensin II have been prepared in which the naturally occurring proline residues have been replaced by the bicyclic…”
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X-ray Structure of Gelatinase A Catalytic Domain Complexed with a Hydroxamate Inhibitor by Dhanaraj, Venugopal, Williams, Mark G., Ye, Qi-Zhuang, Molina, Franck, Johnson, Linda L., Ortwine, Daniel F., Pavlovsky, Alexander, Rubin, J. Ron, Skeean, Richard W., White, Andy D., Humblet, Christine, Hupe, Donald J., Blundell, Tom L.

“…Gelatinase A is a key enzyme in the family of matrix metalloproteinases (matrixins) that are involved in the degradation of the extracellular matrix. As this…”
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