Search Results - "Skeberdis, Arvydas"
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Contribution of branched chain amino acids to energy production and mevalonate synthesis in cancer cells
Published in Biochemical and biophysical research communications (31-12-2021)“…Leucine, isoleucine and valine, known as branched chain amino acids (BCAAs), have been reported to be degraded by different cancer cells, and their…”
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Multi-Omics Analysis Revealed Increased De Novo Synthesis of Serine and Lower Activity of the Methionine Cycle in Breast Cancer Cell Lines
Published in Molecules (Basel, Switzerland) (03-06-2023)“…A pipeline for metabolomics, based on UPLC-ESI-MS, was tested on two malignant breast cancer cell lines of the sub-types ER(+), PR(+), and HER2(3+) (MCF-7 and…”
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3
Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Published in Nature communications (22-11-2017)“…Patients with short QT syndrome (SQTS) may present with syncope, ventricular fibrillation or sudden cardiac death. Six SQTS susceptibility genes, encoding…”
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4
Molecular basis for potentiation of Cx36 gap junction channel conductance by n -alcohols and general anesthetics
Published in Bioscience reports (28-02-2018)“…In our recent study, we have demonstrated that short carbon chain -alcohols (up to octanol) stimulated while long carbon chain -alcohols inhibited the…”
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Cranberry and black chokeberry extracts isolated with pressurized ethanol from defatted by supercritical CO2 pomace inhibit colorectal carcinoma cells and increase global antioxidant response of meat products during in vitro digestion
Published in Food research international (01-11-2022)“…[Display omitted] •Extracts of CO2-defatted cranberry and chokeberry pomace tested in cancer cell lines.•Chokeberry extract was more effective against HCT116…”
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The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation
Published in Nature communications (18-07-2019)“…Once thought to be a remnant of cell division, the midbody (MB) has recently been shown to have roles beyond its primary function of orchestrating abscission…”
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Postsynaptic Density Protein-95 Regulates NMDA Channel Gating and Surface Expression
Published in The Journal of neuroscience (10-11-2004)“…NMDA receptors (NMDARs) colocalize with postsynaptic density protein-95 (PSD-95), a multivalent synaptic scaffolding protein and core component of the…”
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Genome scale metabolic models as tools for drug design and personalized medicine
Published in PloS one (05-01-2018)“…In this work we aim to show how Genome Scale Metabolic Models (GSMMs) can be used as tools for drug design. By comparing the chemical structures of human…”
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Phosphorylation-dependent allosteric regulation of Cx43 gap junction inhibitor potency
Published in Biomedicine & pharmacotherapy (01-05-2024)“…Physiological and pathological processes such as homeostasis, embryogenesis, development, tumorigenesis, and cell movement depend on the intercellular…”
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Fatty Acid Synthesis and Degradation Interplay to Regulate the Oxidative Stress in Cancer Cells
Published in International journal of molecular sciences (18-03-2019)“…Both cytosolic fatty acid synthesis (FAS) and mitochondrial fatty acid oxidation (FAO) have been shown to play a role in the survival and proliferation of…”
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11
Long-distance communication between laryngeal carcinoma cells
Published in PloS one (19-06-2014)“…Tunneling nanotubes and epithelial bridges are recently discovered new forms of intercellular communication between remote cells allowing their electrical…”
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12
Differences in the control of basal L-type Ca2+ current by the cyclic AMP signaling cascade in frog, rat, and human cardiac myocytes
Published in The journal of physiological sciences (01-07-2016)“…β-adrenergic receptors (β-ARs) mediate the positive inotropic effects of catecholamines by cAMP-dependent phosphorylation of the L-type Ca 2+ channels (LTCCs),…”
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13
The effect of nutmeg essential oil constituents on Novikoff hepatoma cell viability and communication through Cx43 gap junctions
Published in Biomedicine & pharmacotherapy (01-03-2021)“…[Display omitted] •Cellular effects of essential oils from plants lack mechanistic explanations and structure–activity relationship testing.•Nutmeg essential…”
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14
Transcriptional hallmarks of cancer cell lines reveal an emerging role of branched chain amino acid catabolism
Published in Scientific reports (10-08-2017)“…A comparative analysis between cancer cell lines and healthy dividing cells was performed using data (289 microarrays and 50 RNA-seq samples) from 100…”
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15
Femtosecond laser micro‐machined polyimide films for cell scaffold applications
Published in Journal of tissue engineering and regenerative medicine (01-02-2018)“…Engineering of sophisticated synthetic 3D scaffolds that allow controlling behaviour and location of the cells requires advanced micro/nano‐fabrication…”
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Midbody: From the Regulator of Cytokinesis to Postmitotic Signaling Organelle
Published in Medicina (Kaunas, Lithuania) (30-07-2018)“…Faithful cell division is crucial for successful proliferation, differentiation, and development of cells, tissue homeostasis, and preservation of genomic…”
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Evaluation of Cx43 Gap Junction Inhibitors Using a Quantitative Structure-Activity Relationship Model
Published in Biomedicines (01-07-2023)“…Gap junctions (GJs) made of connexin-43 (Cx43) are necessary for the conduction of electrical impulses in the heart. Modulation of Cx43 GJ activity may be…”
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Relevance of HCN2-expressing human mesenchymal stem cells for the generation of biological pacemakers
Published in Stem cell research & therapy (30-04-2016)“…The transfection of human mesenchymal stem cells (hMSCs) with the hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) gene has been…”
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FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation
Published in Journal of cell science (01-12-2017)“…The post-mitotic midbody (MB) is a remnant of cytokinesis that can be asymmetrically inherited by one of the daughter cells following cytokinesis. Until…”
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Hyperthermia Differently Affects Connexin43 Expression and Gap Junction Permeability in Skeletal Myoblasts and HeLa Cells
Published in Mediators of Inflammation (01-01-2014)“…Stress kinases can be activated by hyperthermia and modify the expression level and properties of membranous and intercellular channels. We examined the role…”
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