Search Results - "Skarsgard, L D"

Measurements of Relative Biological Effectiveness of the 70 MeV Proton Beam at TRIUMF Using Chinese Hamster V79 Cells and the High-Precision Cell Sorter Assay by Wouters, B. G., Lam, G. K. Y., Oelfke, U., Gardey, K., Durand, R. E., Skarsgard, L. D.

“…Measurements of relative biological effectiveness (RBE) have been made on the range-modulated 70 MeV proton beam at TRI-UMF using a precise cell sorting…”
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Radiobiology with heavy charged particles: a historical review by Skarsgard, L D

“…Radiobiological studies using heavy charged particles followed closely the development of accelerators to produce beams of ever-increasing energy, driven…”
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Low-Dose Hypersensitivity and Increased Radioresistance in a Panel of Human Tumor Cell Lines with Different Radiosensitivity by Wouters, Bradly G., Sy, Arturo M., Skarsgard, Lloyd D.

“…It is well known that cells of human tumor cell lines display a wide range of sensitivity to radiation, at least a part of which can be attributed to different…”
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The Response of a Human Tumor Cell Line to Low Radiation Doses: Evidence of Enhanced Sensitivity by Wouters, B. G., Skarsgard, L. D.

“…The survival of asynchronous, exponentially growing DU-145 human tumor cells was measured after single doses of X rays in the dose range of 0.05-4 Gy using the…”
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Low-Dose Radiation Sensitivity and Induced Radioresistance to Cell Killing in HT-29 Cells Is Distinct from the "Adaptive Response" and Cannot Be Explained by a Subpopulation of Sensitive Cells by Wouters, Bradly G., Skarsgard, Lloyd D.

“…Several reports using two different improved assays of clonogenicity have indicated the presence of a hypersensitive region in the radiation survival response…”
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The cytotoxicity of melphalan and its relationship to pH, hypoxia and drug uptake by Skarsgard, L D, Skwarchuk, M W, Vinczan, A, Kristl, J, Chaplin, D J

“…In the present in vitro studies we examined the effect of hypoxia and acidic pH, two important consequences of reduced blood flow in vivo, on the cytotoxicity…”
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Cell-age heterogeneity and deviations from the LQ model in the radiation survival responses of human tumour cells by HILL, A. A, SKARSGARD, L. D

“…Purpose: To determine whether some of the deviations from the simple linear-quadratic (LQ) theory in the radiation dose-survival responses of asynchronous…”
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Substructure in the cell survival response at low radiation dose: effect of different subpopulations by SKARSGARD, L. D, WOUTERS, B. G

“…In order to obtain more accurate measurements of cell survival after low doses of radiation, we have used the cell sorter assay, in which a cell sorter is used…”
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Lack of correlation between G1 arrest and radiation age-response in three synchronized human tumour cell lines by HILL, A. A, WAN, F, ACHESON, D. K, SKARSGARD, L. D

“…Purpose: To determine radiosensitivity as a function of cell age (the age-response) in three human tumour cell lines, and investigate the dependence of the…”
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Dose Dependence of the Oxygen Enhancement Ratio (OER) in Radiation Inactivation of Chinese Hamster V79-171 Cells by Skarsgard, L. D., Harrison, I.

“…The dose dependence of the oxygen enhancement ratio (OER) has been examined through multiple measurements of the response of Chinese hamster V79-171 cells to…”
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Reduced Oxygen Enhancement Ratio at Low Doses of Ionizing Radiation by Palcic, B., Skarsgard, L. D.

“…A decreased oxygen enhancement ratio (OER) at lower radiation doses has been previously reported (B. Palcic, J. W. Brosing, and L. D. Skarsgard, Br. J. Cancer…”
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The Radiation Response of Asynchronous Cells at Low Dose: Evidence of Substructure by Skarsgard, Lloyd D., Harrison, Isabel, Durand, Ralph E.

“…Flow cytometry and cell sorting techniques have been used together with repeated measurement in an attempt to define better the radiation survival response of…”
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Substructure in the Radiation Survival Response at Low Dose in Cells of Human Tumor Cell Lines by Skarsgard, Lloyd D., Skwarchuk, Mark W., Wouters, Bradly G., Durand, Ralph E.

“…In earlier studies using asynchronously growing Chinese hamster cells, we observed substructure in the survival response at low doses. The substructure…”
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The Survival of Asynchronous V79 Cells at Low Radiation Doses: Modeling the Response of Mixed Cell Populations by Skarsgard, L. D., Skwarchuk, M. W., Wouters, B. G.

“…We have observed that when a single linear-quadratic (LQ) function is used to fit the radiation survival response of an asynchronously dividing population of…”
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Hypoxic cell sensitization: low-dose intrinsic radiosensitivity is predictive for etanidazole efficacy in a panel of human tumour cell lines by Wouters, B G, Sy, A M, Skarsgard, L D

“…We used a cell sorter assay to evaluate the efficacy of the hypoxic cell sensitizer etanidazole over 3-4 logs of cell inactivation, with particular attention…”
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Survival at Low Dose in Asynchronous and Partially Synchronized Chinese Hamster V79-171 Cells by Skarsgard, Lloyd D., Wilson, Douglas J., Durand, Ralph E.

“…In an earlier study using cell sorting techniques to define the radiation survival response of asynchronous Chinese hamster V79-171 cells more accurately, we…”
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The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells by SKARSGARD, L. D, SKWARCHUK, M. W, VINCZAN, A, CHAPLIN, D. J

“…We have observed that low pH can substantially potentiate the cytotoxic effect of the bioreductive drug SR4233 in aerobic HT-29 human tumour cells. No such…”
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Cytotoxic effect of RB 6145 in human tumour cell lines: dependence on hypoxia, extra- and intracellular pH and drug uptake by SKARSGARD, L. D, ACHESON, D. K, VINCZAN, A, WOUTERS, B. G, HEINRICHS, B. E, LOBLAW, D. A, MINCHINTON, A. I, CHAPLIN, D. J

“…Low pH and hypoxia are a common feature of many solid tumours. This study examined the effect of these two conditions on the cytotoxic properties of the…”
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Substructure in the radiation survival response at low dose: asynchronous and partially synchronized V79-WNRE cells by Skwarchuk, M W, Wouters, B G, Skarsgard, L D

“…The radiation survival response of asynchronously-dividing populations of the cell line V79-WNRE indicates substructure in the low dose region that can be…”
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A general cavity theory by Haider, J A, Skarsgard, L D, Lam, G K

“…A cavity theory is used to relate the dose deposited in the cavity (sensitive volume of the detector) to that in the surrounding medium which may be of…”
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