Search Results - "Skarsfeldt, Mark A."

Pharmacological inhibition of SK‐channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events by Linz, Benedikt, Hesselkilde, Eva M., Skarsfeldt, Mark A., Hertel, Julie N., Sattler, Stefan M., Yan, Yannan, Tfelt‐Hansen, Jacob, Diness, Jonas G., Bentzen, Bo H., Linz, Dominik, Jespersen, Thomas

“…Background Obstructive sleep apnea (OSA) creates a complex substrate for atrial fibrillation (AF), which is refractory to many clinically available…”
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Polyunsaturated fatty acid‐derived IKs channel activators shorten the QT interval ex‐vivo and in‐vivo by Skarsfeldt, Mark A., Liin, Sara I., Larsson, Hans P., Bentzen, Bo H.

“…Aim We aimed to assess the ability of natural and modified polyunsaturated fatty acids (PUFAs) to shorten QT interval in ex‐vivo and in‐vivo guinea pig hearts…”
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Polyunsaturated fatty acid-derived I Ks channel activators shorten the QT interval ex-vivo and in-vivo by Skarsfeldt, Mark A, Liin, Sara I, Larsson, Hans P, Bentzen, Bo H

“…We aimed to assess the ability of natural and modified polyunsaturated fatty acids (PUFAs) to shorten QT interval in ex-vivo and in-vivo guinea pig hearts. The…”
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Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval by Hiniesto-Iñigo, Irene, Castro-Gonzalez, Laura M., Corradi, Valentina, Skarsfeldt, Mark A., Yazdi, Samira, Lundholm, Siri, Nikesjö, Johan, Noskov, Sergei Yu, Bentzen, Bo Hjorth, Tieleman, D. Peter, Liin, Sara I.

“…Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown…”
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pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts by Skarsfeldt, Mark A., Jepps, Thomas A., Bomholtz, Sofia H., Abildgaard, Lea, Sørensen, Ulrik S., Gregers, Emilie, Svendsen, Jesper H., Diness, Jonas G., Grunnet, Morten, Schmitt, Nicole, Olesen, Søren-Peter, Bentzen, Bo H.

“…In isolated human atrial cardiomyocytes, inhibition of K 2P 3.1 K + channels results in action potential (action potential duration (APD)) prolongation. It has…”
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Electrophysiologic effects of the IK1 inhibitor PA‐6 are modulated by extracellular potassium in isolated guinea pig hearts by Hoeker, Gregory S., Skarsfeldt, Mark A., Jespersen, Thomas, Poelzing, Steven

“…The pentamidine analog PA‐6 was developed as a specific inward rectifier potassium current (IK1) antagonist, because established inhibitors either lack…”
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Electrophysiologic effects of the I K 1 inhibitor PA-6 are modulated by extracellular potassium in isolated guinea pig hearts by Hoeker, Gregory S., Skarsfeldt, Mark A., Jespersen, Thomas, Poelzing, Steven

“…The pentamidine analog PA‐6 was developed as a specific inward rectifier potassium current (IK1) antagonist, because established inhibitors either lack…”
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Pharmacological inhibition of IK1 by PA‐6 in isolated rat hearts affects ventricular repolarization and refractoriness by Skarsfeldt, Mark A., Carstensen, Helena, Skibsbye, Lasse, Tang, Chuyi, Buhl, Rikke, Bentzen, Bo H., Jespersen, Thomas

“…The inwardly rectifying potassium current (IK1) conducted through Kir2.X channels contribute to repolarization of the cardiac action potential and to…”
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Pharmacological inhibition of I K 1 by PA-6 in isolated rat hearts affects ventricular repolarization and refractoriness by Skarsfeldt, Mark A., Carstensen, Helena, Skibsbye, Lasse, Tang, Chuyi, Buhl, Rikke, Bentzen, Bo H., Jespersen, Thomas

“…The inwardly rectifying potassium current (IK1) conducted through Kir2.X channels contribute to repolarization of the cardiac action potential and to…”
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Polyunsaturated fatty acid-derivedI(Ks)channel activators shorten the QT interval ex-vivo and in-vivo by Skarsfeldt, Mark, Liin, Sara, Larsson, Hans P., Bentzen, Bo H.

“…Aim We aimed to assess the ability of natural and modified polyunsaturated fatty acids (PUFAs) to shorten QT interval in ex-vivo and in-vivo guinea pig hearts…”
Get full text

N-Arachidonoyl Taurine Rescues Diverse Long QT Syndrome-Associated Mutations in the Cardiac I←Ks Channel by Liin, Sara I., Larsson, Johan E., Barro-Soria, Rene, Skarsfeldt, Mark A., Bentzen, Bo H., Larsson, H Peter

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Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT intervalResearch in context by Irene Hiniesto-Iñigo, Laura M. Castro-Gonzalez, Valentina Corradi, Mark A. Skarsfeldt, Samira Yazdi, Siri Lundholm, Johan Nikesjö, Sergei Yu Noskov, Bo Hjorth Bentzen, D. Peter Tieleman, Sara I. Liin

“…Background: Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with…”
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Electrophysiologic effects of the IK 1 inhibitor PA‐6 are modulated by extracellular potassium in isolated guinea pig hearts by Hoeker, Gregory S., Skarsfeldt, Mark A., Jespersen, Thomas, Poelzing, Steven

“…The pentamidine analog PA ‐6 was developed as a specific inward rectifier potassium current ( I K 1 ) antagonist, because established inhibitors either lack…”
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Endocannabinoids enhance hK V 7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval by Hiniesto-Iñigo, Irene, Castro-Gonzalez, Laura M, Corradi, Valentina, Skarsfeldt, Mark A, Yazdi, Samira, Lundholm, Siri, Nikesjö, Johan, Noskov, Sergei Yu, Bentzen, Bo Hjorth, Tieleman, D Peter, Liin, Sara I

“…Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown…”
Get full text

Electrophysiologic effects of the I sub(K) sub(1) inhibitor PA-6 are modulated by extracellular potassium in isolated guinea pig hearts by Hoeker, Gregory S, Skarsfeldt, Mark A, Jespersen, Thomas, Poelzing, Steven

“…The pentamidine analog PA-6 was developed as a specific inward rectifier potassium current (I sub(K) sub(1) ) antagonist, because established inhibitors either…”
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pH-dependent inhibition of K^sub 2P^3.1 prolongs atrial refractoriness in whole hearts by Skarsfeldt, Mark A, Jepps, Thomas A, Bomholtz, Sofia H, Abildgaard, Lea, Sørensen, Ulrik S, Gregers, Emilie, Svendsen, Jesper H, Diness, Jonas G, Grunnet, Morten, Schmitt, Nicole, Olesen, Søren-peter, Bentzen, Bo H

“…In isolated human atrial cardiomyocytes, inhibition of K^sub 2P^3.1 K^sup +^ channels results in action potential (action potential duration (APD))…”
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Pharmacological inhibition of I sub(K) sub(1) by PA-6 in isolated rat hearts affects ventricular repolarization and refractoriness by Skarsfeldt, Mark A, Carstensen, Helena, Skibsbye, Lasse, Tang, Chuyi, Buhl, Rikke, Bentzen, Bo H, Jespersen, Thomas

“…The inwardly rectifying potassium current (I sub(K) sub(1) ) conducted through K sub(ir)2.X channels contribute to repolarization of the cardiac action…”
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Pharmacological inhibition of IK 1 by PA‐6 in isolated rat hearts affects ventricular repolarization and refractoriness by Skarsfeldt, Mark A., Carstensen, Helena, Skibsbye, Lasse, Tang, Chuyi, Buhl, Rikke, Bentzen, Bo H., Jespersen, Thomas

“…The inwardly rectifying potassium current ( I K 1 ) conducted through K ir 2.X channels contribute to repolarization of the cardiac action potential and to…”
Get full text