Search Results - "Skarsfeldt, Mark"

Polyunsaturated fatty acid-derivedI(Ks)channel activators shorten the QT interval ex-vivo and in-vivo by Skarsfeldt, Mark, Liin, Sara, Larsson, Hans P., Bentzen, Bo H.

“…Aim We aimed to assess the ability of natural and modified polyunsaturated fatty acids (PUFAs) to shorten QT interval in ex-vivo and in-vivo guinea pig hearts…”
Get full text

Polyunsaturated fatty acid‐derived IKs channel activators shorten the QT interval ex‐vivo and in‐vivo by Skarsfeldt, Mark A., Liin, Sara I., Larsson, Hans P., Bentzen, Bo H.

“…Aim We aimed to assess the ability of natural and modified polyunsaturated fatty acids (PUFAs) to shorten QT interval in ex‐vivo and in‐vivo guinea pig hearts…”
Get full text

Pharmacological inhibition of SK‐channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events by Linz, Benedikt, Hesselkilde, Eva M., Skarsfeldt, Mark A., Hertel, Julie N., Sattler, Stefan M., Yan, Yannan, Tfelt‐Hansen, Jacob, Diness, Jonas G., Bentzen, Bo H., Linz, Dominik, Jespersen, Thomas

“…Background Obstructive sleep apnea (OSA) creates a complex substrate for atrial fibrillation (AF), which is refractory to many clinically available…”
Get full text

Structure-function analysis of time-resolved immunological phases in metabolic dysfunction-associated fatty liver disease (MASH) comparing the NIF mouse model to human MASH by Schmidt-Christensen, Anja, Eriksson, Gustaw, Laprade, William M., Pirzamanbein, Behnaz, Hörnberg, Maria, Linde, Kajsa, Nilsson, Julia, Skarsfeldt, Mark, Leeming, Diana J., Mokso, Rajmund, Verezhak, Mariana, Dahl, Anders, Dahl, Vedrana, Önnerhag, Kristina, Oghazi, Massoud Rezaee, Mayans, Sofia, Holmberg, Dan

“…Metabolic dysfunction-associated steatohepatitis (MASH) is a common but frequently unrecognized complication of obesity and type 2 diabetes. The association…”
Get full text

Polyunsaturated fatty acid-derived I Ks channel activators shorten the QT interval ex-vivo and in-vivo by Skarsfeldt, Mark A, Liin, Sara I, Larsson, Hans P, Bentzen, Bo H

“…We aimed to assess the ability of natural and modified polyunsaturated fatty acids (PUFAs) to shorten QT interval in ex-vivo and in-vivo guinea pig hearts. The…”
Get full text

Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval by Hiniesto-Iñigo, Irene, Castro-Gonzalez, Laura M., Corradi, Valentina, Skarsfeldt, Mark A., Yazdi, Samira, Lundholm, Siri, Nikesjö, Johan, Noskov, Sergei Yu, Bentzen, Bo Hjorth, Tieleman, D. Peter, Liin, Sara I.

“…Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown…”
Get full text

pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts by Skarsfeldt, Mark A., Jepps, Thomas A., Bomholtz, Sofia H., Abildgaard, Lea, Sørensen, Ulrik S., Gregers, Emilie, Svendsen, Jesper H., Diness, Jonas G., Grunnet, Morten, Schmitt, Nicole, Olesen, Søren-Peter, Bentzen, Bo H.

“…In isolated human atrial cardiomyocytes, inhibition of K 2P 3.1 K + channels results in action potential (action potential duration (APD)) prolongation. It has…”
Get full text

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel by Liin, Sara I, Silverå Ejneby, Malin, Barro-Soria, Rene, Skarsfeldt, Mark Alexander, Larsson, Johan E, Starck Härlin, Frida, Parkkari, Teija, Bentzen, Bo Hjorth, Schmitt, Nicole, Larsson, H Peter, Elinder, Fredrik

“…Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7.1 and the β-subunit KCNE1 form the cardiac IKs channel that is central for cardiac…”
Get full text

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I Ks channel by Liin, Sara I., Silverå Ejneby, Malin, Barro-Soria, Rene, Skarsfeldt, Mark Alexander, Larsson, Johan E., Starck Härlin, Frida, Parkkari, Teija, Bentzen, Bo Hjorth, Schmitt, Nicole, Larsson, H. Peter, Elinder, Fredrik

“…More than 300 mutations in the genes encoding the cardiac I Ks channel have been identified in patients with cardiac arrhythmia. These mutations cause either…”
Get full text

Electrophysiologic effects of the IK1 inhibitor PA‐6 are modulated by extracellular potassium in isolated guinea pig hearts by Hoeker, Gregory S., Skarsfeldt, Mark A., Jespersen, Thomas, Poelzing, Steven

“…The pentamidine analog PA‐6 was developed as a specific inward rectifier potassium current (IK1) antagonist, because established inhibitors either lack…”
Get full text

Electrophysiologic effects of the I K 1 inhibitor PA-6 are modulated by extracellular potassium in isolated guinea pig hearts by Hoeker, Gregory S., Skarsfeldt, Mark A., Jespersen, Thomas, Poelzing, Steven

“…The pentamidine analog PA‐6 was developed as a specific inward rectifier potassium current (IK1) antagonist, because established inhibitors either lack…”
Get full text

Pharmacological inhibition of IK1 by PA‐6 in isolated rat hearts affects ventricular repolarization and refractoriness by Skarsfeldt, Mark A., Carstensen, Helena, Skibsbye, Lasse, Tang, Chuyi, Buhl, Rikke, Bentzen, Bo H., Jespersen, Thomas

“…The inwardly rectifying potassium current (IK1) conducted through Kir2.X channels contribute to repolarization of the cardiac action potential and to…”
Get full text

Small conductance calcium activated K+ channel inhibitor decreases stretch induced vulnerability to atrial fibrillation by Yan, Yannan, Skarsfeldt, Mark Alexander, Diness, Jonas Goldin, Bentzen, Bo Hjorth

“…Atrial dilation is an important risk factor for atrial fibrillation (AF) and animal studies have found that acute atrial dilation shortens the atrial effective…”
Get full text

Pharmacological inhibition of I K 1 by PA-6 in isolated rat hearts affects ventricular repolarization and refractoriness by Skarsfeldt, Mark A., Carstensen, Helena, Skibsbye, Lasse, Tang, Chuyi, Buhl, Rikke, Bentzen, Bo H., Jespersen, Thomas

“…The inwardly rectifying potassium current (IK1) conducted through Kir2.X channels contribute to repolarization of the cardiac action potential and to…”
Get full text

Inhibition of KCa2 Channels Decreased the Risk of Ventricular Arrhythmia in the Guinea Pig Heart During Induced Hypokalemia by Diness, Jonas Goldin, Abildgaard, Lea, Bomholtz, Sofia Hammami, Skarsfeldt, Mark Alexander, Edvardsson, Nils, Sørensen, Ulrik S., Grunnet, Morten, Bentzen, Bo Hjorth

“…BACKGROUNDHypokalemia reduces the cardiac repolarization reserve. This prolongs the QT-interval and increases the risk of ventricular arrhythmia; a risk that…”
Get full text

The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts by Kirchhoff, Jeppe Egedal, Skarsfeldt, Mark Alexander, Muthukumarasamy, Kalai Mangai, Simó-Vicens, Rafel, Bomholtz, Sofia Hammami, Abildgaard, Lea, Jespersen, Thomas, Sørensen, Ulrik S., Grunnet, Morten, Bentzen, Bo Hjorth, Diness, Jonas Goldin

“…Background and Purpose: Prolongation of cardiac action potentials is considered antiarrhythmic in the atria but can be proarrhythmic in ventricles if the…”
Get full text

Magnetocardiography on an isolated animal heart with a room-temperature optically pumped magnetometer by Jensen, Kasper, Skarsfeldt, Mark Alexander, Stærkind, Hans, Arnbak, Jens, Balabas, Mikhail V., Olesen, Søren-Peter, Bentzen, Bo Hjorth, Polzik, Eugene S.

“…Optically pumped magnetometers are becoming a promising alternative to cryogenically-cooled superconducting magnetometers for detecting and imaging biomagnetic…”
Get full text

N-Arachidonoyl Taurine Rescues Diverse Long QT Syndrome-Associated Mutations in the Cardiac I←Ks Channel by Liin, Sara I., Larsson, Johan E., Barro-Soria, Rene, Skarsfeldt, Mark A., Bentzen, Bo H., Larsson, H Peter

Get full text

Electrophysiologic effects of the IK 1 inhibitor PA‐6 are modulated by extracellular potassium in isolated guinea pig hearts by Hoeker, Gregory S., Skarsfeldt, Mark A., Jespersen, Thomas, Poelzing, Steven

“…The pentamidine analog PA ‐6 was developed as a specific inward rectifier potassium current ( I K 1 ) antagonist, because established inhibitors either lack…”
Get full text

Inhibition of K Ca 2 Channels Decreased the Risk of Ventricular Arrhythmia in the Guinea Pig Heart During Induced Hypokalemia by Diness, Jonas Goldin, Abildgaard, Lea, Bomholtz, Sofia Hammami, Skarsfeldt, Mark Alexander, Edvardsson, Nils, Sørensen, Ulrik S, Grunnet, Morten, Bentzen, Bo Hjorth

“…Hypokalemia reduces the cardiac repolarization reserve. This prolongs the QT-interval and increases the risk of ventricular arrhythmia; a risk that is…”
Get full text