Search Results - "Skarpen, E."

Enhanced targeting of triple-negative breast carcinoma and malignant melanoma by photochemical internalization of CSPG4-targeting immunotoxins by Eng, M S, Kaur, J, Prasmickaite, L, Engesæter, B Ø, Weyergang, A, Skarpen, E, Berg, K, Rosenblum, M G, Mælandsmo, G M, Høgset, A, Ferrone, S, Selbo, P K

“…Triple-negative breast cancer (TNBC) and malignant melanoma are highly aggressive cancers that widely express the cell surface chondroitin sulfate proteoglycan…”
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Activation of the p53-p21 pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytes by Wierød, L, Rosseland, C M, Lindeman, B, Oksvold, M P, Grøsvik, H, Skarpen, E, Huitfeldt, H S

“…p53 plays a major role in the prevention of tumor development. It responds to a range of potentially oncogenic stresses by activating protective mechanisms,…”
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Altered regulation of EGF receptor signaling following a partial hepatectomy by Skarpen, E., Oksvold, M.P., Grøsvik, H., Widnes, C., Huitfeldt, H.S.

“…We have studied epidermal growth factor receptor (EGFR) phosphorylation and localization in the pre‐replicative phase of liver regeneration induced by a 70%…”
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CDK2 regulation through PI3K and CDK4 is necessary for cell cycle progression of primary rat hepatocytes by Wierød, L., Rosseland, C. M., Lindeman, B., Oksvold, M. P., Grøsvik, H., Skarpen, E., Huitfeldt, H. S.

“…  Introduction/Objectives: Cell cycle progression is driven by the coordinated regulation of cyclin‐dependent kinases (CDKs). In response to mitogenic…”
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Remodeling of secretory lysosomes during education tunes functional potential in NK cells by Goodridge, Jodie P., Jacobs, Benedikt, Saetersmoen, Michelle L., Clement, Dennis, Hammer, Quirin, Clancy, Trevor, Skarpen, Ellen, Brech, Andreas, Landskron, Johannes, Grimm, Christian, Pfefferle, Aline, Meza-Zepeda, Leonardo, Lorenz, Susanne, Wiiger, Merete Thune, Louch, William E., Ask, Eivind Heggernes, Liu, Lisa L., Oei, Vincent Yi Sheng, Kjällquist, Una, Linnarsson, Sten, Patel, Sandip, Taskén, Kjetil, Stenmark, Harald, Malmberg, Karl-Johan

“…Inhibitory signaling during natural killer (NK) cell education translates into increased responsiveness to activation; however, the intracellular mechanism for…”
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The tankyrase inhibitor G007-LK inhibits small intestine LGR5 + stem cell proliferation without altering tissue morphology by Norum, Jens Henrik, Skarpen, Ellen, Brech, Andreas, Kuiper, Raoul, Waaler, Jo, Krauss, Stefan, Sørlie, Therese

“…The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for…”
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CELL-SPECIFIC EXPRESSION OF CCAAT/ENHANCER-BINDING PROTEIN delta (C/EBPdelta) IN EPITHELIAL LUNG CELLS by Lag, M., Skarpen, E., Van Rozendaal, B. A. W. M., Haagsman, H. P., Huitfeldt, H. S., Thrane, E. V.

“…CCAAT/enhancer-binding proteins (C/EBP) constitute a family of transcription factors that are involved in regulation of proliferation and differentiation in…”
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Localization of cAMP-dependent signal transducers in early rat liver carcinogenesis by Skarpen, E, Thoresen, G H, Taskén, K, Samuelsen, J T, Jahnsen, T, Schwarze, P E, Huitfeldt, H S

“…Cyclic AMP (cAMP) is an important regulator of liver growth and differentiation. The main intracellular cAMP receptor, cAMP-dependent protein kinase (PKA),…”
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Role of the mucolipin Ca 2+ -channel family in lysosome homeostasis and Natural Killer Cell function by Clement, D, Krokeide, SZ, Skarpen, E, Goodridge, J, Malmberg, KJ

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Gene Activation Studied by Immunological Methods by Huitfeldt, Henrik S., Heyden, Anders, Skarpen, Ellen, Thrane, E. Vibeke, Schwarze, Per E.

“…Gene activation can be studied at several levels: transcription (mRNA), translation (proteins), or phenotypical alterations (functional activity or…”
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The tankyrase inhibitor G007-LK inhibits small intestine Lgr5+stem cell proliferation without altering tissue morphology by Norum, JH, Skarpen, E, Brech, A, Kuiper, R, Waaler, J, Krauss, S, Sorlie, T

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NK cell receptor inhibition determines NK cell cytolytic potential through accumulated granular load by Goodridge, J, Clancy, T, Jacobs, B, Pfefferle, A, Brech, A, Skarpen, E, Stenmark, H, Malmberg, KJ

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Cytoplasmic retention of peroxide-activated ERK provides survival in primary cultures of rat hepatocytes by ROSSELAND, Carola M, WIERØD, Lene, OKSVOLD, Morten P, WERNER, Heidi, ØSTVOLD, Anne Carine, THORESEN, G. Hege, PAULSEN, Ragnhild E, HUITFELDT, Henrik S, SKARPEN, Ellen

“…Reactive oxygen species (ROS) are implicated in tissue damage causing primary hepatic dysfunction following ischemia/reperfusion injury and during inflammatory…”
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Activation of the p53-[p21.sub.Cip1] pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytes by Wierod, L, Rooseland, C.M, Linderman, B, Oksvold, M.P, Grosvik, H, Skarpen, E, Huitfeldt, H.S

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The effect of a tankyrase inhibitor on the small intestine tissue homeostasis by Norum, JH, Skarpen, E, Brech, A, Kuiper, R, Waaler, J, Krauss, S, Sorlie, T

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Activation of the p53-p21 super(Cip1) pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytes by Wieroed, L, Rosseland, C M, Lindeman, B, Oksvold, M P, Groesvik, H, Skarpen, E, Huitfeldt, H S

“…p53 plays a major role in the prevention of tumor development. It responds to a range of potentially oncogenic stresses by activating protective mechanisms,…”
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Activation of the p53–p21Cip1 pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytes by Wierød, L, Rosseland, C M, Lindeman, B, Oksvold, M P, Grøsvik, H, Skarpen, E, Huitfeldt, H S

“…p53 plays a major role in the prevention of tumor development. It responds to a range of potentially oncogenic stresses by activating protective mechanisms,…”
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Early cellular alterations in chemical liver carcinogenesis as addressed by immunohistochemical and molecular biological techniques by Huitfeldt, H S, Skarpen, E, Lindeman, B, van Gijssel, H E, Nyhus, P A, Leyshon-Sørland, K

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UV induces tyrosine kinase-independent internalisation and endosome arrest of the EGF receptor by Oksvold, Morten P, Huitfeldt, Henrik S, Østvold, Anne Carine, Skarpen, Ellen

“…We have compared the activation and trafficking of epidermal growth factor receptor (EGFR) induced by UV light and EGF. Tyrosine phosphorylation of EGFR was…”
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Re-localization of activated EGF receptor and its signal transducers to multivesicular compartments downstream of early endosomes in response to EGF by Oksvold, Morten P., Skarpen, Ellen, Wierød, Lene, Paulsen, Ragnhild E., Huitfeldt, Henrik S.

“…The rapid internalization of receptor tyrosine kinases after ligand binding has been assumed to be a negative modulation of signal transduction. However,…”
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