Search Results - "Skarosi, S."

A vitamin D3 analog induces a G1-phase arrest in CaCo-2 cells by inhibiting cdk2 and cdk6: roles of cyclin E, p21Waf1, and p27Kip1 by Scaglione-Sewell, B A, Bissonnette, M, Skarosi, S, Abraham, C, Brasitus, T A

“…Previous studies by our laboratory have shown that a noncalcemic fluorinated analog of 1alpha,25-dihydroxyvitamin D3,…”
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Decreased PKC-α expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells by SCAGLIONE-SEWELL, B, ABRAHAM, C, BISSONNETTE, M, SKAROSI, S. F, HART, J, DAVIDSON, N. O, WALI, R. K, DAVIS, B. H, SITRIN, M, BRASITUS, T. A

“…Previous studies have shown that PKC-alpha protein expression is decreased in sporadic human colon cancers, as well as in colonic tumors of rats induced by…”
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Protein kinase C α modulates growth and differentiation in Caco-2 cells by Abraham, Clara, Scaglione–Sewell, Beth, Skarosi, Susan F., Qin, Wenying, Bissonnette, Marc, Brasitus, Thomas A.

“…Background & Aims: Caco-2 cells have been used extensively to elucidate events involved in intestinal cell proliferation and differentiation. Because…”
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Tissue-specific, developmental and nutritional regulation of the gene encoding the catalytic subunit of the rat apolipoprotein B mRNA editing enzyme: functional role in the modulation of apoB mRNA editing by Funahashi, T, Giannoni, F, DePaoli, A M, Skarosi, S F, Davidson, N O

“…Apolipoprotein B (apoB) mRNA editing, a posttranscriptional site-specific cytidine deamination reaction, is mediated by a protein complex of which the…”
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1,25 dihydroxyvitamin D3 stimulates phospholipase C-gamma in rat colonocytes: role of c-Src in PLC-gamma activation by Khare, S, Bolt, M J, Wali, R K, Skarosi, S F, Roy, H K, Niedziela, S, Scaglione-Sewell, B, Aquino, B, Abraham, C, Sitrin, M D, Brasitus, T A, Bissonnette, M

“…Our laboratory has previously demonstrated that 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) rapidly stimulated polyphosphoinositide (PI) hydrolysis, raised…”
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Effects of 1,25-dihydroxyvitamin D3 on proliferation and differentiation of Caco-2 cells by Halline, A G, Davidson, N O, Skarosi, S F, Sitrin, M D, Tietze, C, Alpers, D H, Brasitus, T A

“…The effect of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], or calcitriol, on the proliferation and differentiation of Caco-2 cells was studied. Vitamin D receptor…”
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Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein by Hadjiagapiou, Christos, Giannoni, Federico, Funahashi, Toru, Skarosi, Susan F., Davidson, Nicholas O.

“…Mammalian small intestinal apolipoprotein B (apo B) mRNA undergoes posttranscriptional cytidine deamination with the production of an in frame stop codon and…”
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Rapid effects of 1,25(OH)2 vitamin D3 on signal transduction systems in colonic cells by SITRIN, M. D, BISSONNETTE, M, BOLT, M. J. G, WALI, R, KHARE, S, SCAGLIONE-SEWELL, B, SKAROSI, S, BRASITUS, T. A

“…Previous work from our laboratory demonstrated that 1,25(OH)2D3 rapidly stimulated hydrolysis of membrane polyphosphoinositides (PI) in rat colonocytes and in…”
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A Vitamin D3 Analog Induces a G1-Phase Arrest in CaCo-2 Cells by Inhibiting Cdk2 and Cdk6: Roles of Cyclin E, p21Waf1, and p27Kip1This work was supported by National Institutes of Health Grants DK-39573, CA-36745 (to T.A.B. and M.B.) and P30DK42086 (to T.A.B., Digestive Disease Research Core Center) by Scaglione-Sewell, B A, Bissonnette, M, Skarosi, S, Abraham, C, Brasitus, T A

“…Previous studies by our laboratory have shown that a noncalcemic fluorinated analog of 1α,25-dihydroxyvitamin D3,…”
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Developmental regulation of the catalytic subunit of the apolipoprotein B mRNA editing enzyme (APOBEC-1) in human small intestine by Giannoni, F, Chou, S C, Skarosi, S F, Verp, M S, Field, F J, Coleman, R A, Davidson, N O

“…Apolipoprotein (apo) B mRNA editing is a site-specific cytidine deamination reaction responsible for the production of apoB-48 in mammalian small intestine…”
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Expression of a recombinant apolipoprotein(a) in HepG2 cells. Evidence for intracellular assembly of lipoprotein(a) by Bonen, D K, Hausman, A M, Hadjiagapiou, C, Skarosi, S F, Davidson, N O

“…Apolipoprotein(a) (apo(a)), a large glycoprotein with extensive homology to plasminogen, forms a complex with apolipoprotein B100 (apoB100), which circulates…”
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Tissue and cell-specific patterns of expression of rat liver and intestinal fatty acid binding protein during development and in experimental colonic and small intestinal adenocarcinomas by Davidson, N O, Ifkovits, C A, Skarosi, S F, Hausman, A M, Llor, X, Sitrin, M D, Montag, A, Brasitus, T A

“…Mammalian small intestinal and colonic epithelium express members of a multigene family of hydrophobic ligand binding proteins of which liver and intestinal…”
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A Vitamin D 3 Analog Induces a G1-Phase Arrest in CaCo-2 Cells by Inhibiting Cdk2 and Cdk6: Roles of Cyclin E, p21 Waf1 , and p27 Kip1 1 by Scaglione-Sewell, B. A., Bissonnette, M., Skarosi, S., Abraham, C., Brasitus, T. A.

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A Vitamin D3 Analog Induces a G1-Phase Arrest in CaCo-2 Cells by Inhibiting Cdk2 and Cdk6: Roles of Cyclin E, p21Waf1, and p27Kip11 by Scaglione-Sewell, B. A, Bissonnette, M, Skarosi, S, Abraham, C, Brasitus, T. A

“…Previous studies by our laboratory have shown that a noncalcemic fluorinated analog of 1α,25-dihydroxyvitamin D3,…”
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Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats by Wali, R K, Skarosi, S, Hart, J, Zhang, Y, Dolan, M E, Moschel, R C, Nguyen, L, Mustafi, R, Brasitus, T A, Bissonnette, M

“…Azoxymethane (AOM) causes O(6)-methylguanine adduct formation which leads to G-->A transitions. Their repair is carried out by O(6)-methylguanine-DNA…”
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Mutational and Nonmutational Activation of p21 super(ras) in Rat Colonic Azoxymethane-induced Tumors: Effects on Mitogen-activated Protein Kinase, Cyclooxygenase-2, and Cyclin D1 by Bissonnette, M, Khare, S, Von Lintig, FC, Wali, R K, Nguyen, L, Zhang, Yingchun, Hart, J, Skarosi, S, Varki, N, Boss, G R, Brasitus, T A

“…Azoxymethane (AOM)-induced colonic carcinogenesis involves a number of mutations, including those in the K-ras gene and CTNNB1, that codes for beta -catenin…”
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1,25-Dihydroxyvitamin D3 targets PKC-betaII but not PKC-alpha to the basolateral plasma membranes of rat colonocytes by Wali, R K, Bissonnette, M, Skarosi, S, Khare, S, Sitrin, M, Brasitus, T A

“…Prior studies by our laboratory have shown that 1, 25-dihydroxyvitamin D3 activated PKC-alpha, but not PKC-delta, -epsilon, or -zeta, in normal rat…”
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1,25-Dihydroxyvitamin D Targets PKC- beta II but Not PKC- alpha to the Basolateral Plasma Membranes of Rat Colonocytes by Wali, R K, Bissonnette, M, Skarosi, S, Khare, S, Sitrin, M, Brasitus, T A

“…Prior studies by our laboratory have shown that 1,25-dihydroxyvitamin D sub(3) activated PKC- alpha , but not PKC- delta , - upsilon , or - zeta , in normal…”
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Ursodeoxycholate and a fluorinated analogue of 1,25-dihydroxyvitamin D3 inhibit aberrant crypt formation in the azoxymethane model of rat colonic carcinogenesis by Wali, R., Skarosi, S., Hart, J., Bissonnette, M., Sitrin, M., Brasitus, T.

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A fluorinated synthetic analog of vitamin D3 induces G0/G1 arrest in Caco-2 cells and increases expression of p21Wafl and p27Kipi by Scaglione-Sewell, B.A., Skarosi, S., Bissonnette, M., Sitrin, M., Brasitus, T.A.

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