Search Results - "Skarbek, Charles"

Camouflaging endovascular stents with an endothelial coat using CD31 domain 1 and 2 mimetic peptides by Sénémaud, Jean, Skarbek, Charles, Hernandez, Belen, Song, Ran, Lefevre, Isabelle, Bianchi, Elisabetta, Castier, Yves, Nicoletti, Antonino, Bureau, Christophe, Caligiuri, Giuseppina

“…Implantation of an endovascular device disrupts the homeostatic CD31:CD31 interactions among quiescent endothelial cells (ECs), platelets, and circulating…”
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Oxazaphosphorines combined with immune checkpoint blockers: dose-dependent tuning between immune and cytotoxic effects by Delahousse, Julia, Skarbek, Charles, Desbois, Mélanie, Perfettini, Jean-Luc, Chaput, Nathalie, Paci, Angelo

“…BackgroundOxazaphosphorines (cyclophosphamide (CPA), ifosfamide (IFO)) are major alkylating agents of polychemotherapy protocols but limiting their toxicity…”
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Between the Devil and the Deep Blue Sea: New Insights into the Effects of Cancer Therapy on Abdominal Aortic Aneurysm Growth by Sénémaud, Jean, Skarbek, Charles

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Anticancer boron-containing prodrugs responsive to oxidative stress from the tumor microenvironment by Maslah, Hichem, Skarbek, Charles, Pethe, Stéphanie, Labruère, Raphaël

“…Boronic acid (and ester) prodrugs targeting the overexpressed level of reactive oxygen species within tumor microenvironment represent a promising area for the…”
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CD31 Coated Surfaces Enhance Endothelialisation and Reduce Platelet Adhesion: A Promising Strategy for Improving Stent Graft Biocompatibility by Senemaud, Jean, Skarbek, Charles, Song, Tina, Pan, Zongcheng, Bureau, Christophe, Caligiuri, Giuseppina

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Synthesis of 6-methylphenanthridines and evaluation against human papillomavirus-related endocervical adenocarcinoma (KB 3.1) cells by Maslah, Hichem, Skarbek, Charles, Labruère, Raphaël

“…This study describes the synthesis of a series of 6-methylphenanthridines and their evaluation as cytotoxic agents. An unprecedented one-pot synthesis…”
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Molecular Imaging of Experimental Abdominal Aortic Aneurysms Targeting Vascular Homeostasis Disruption via CD31 Shedding by Sénémaud, Jean N., Skarbek, Charles, Vigne, Jonathan, Rouzet, Francois, Castier, Yves, Caligiuri, Giuseppina

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In‐Cell Generation of Anticancer Phenanthridine Through Bioorthogonal Cyclization in Antitumor Prodrug Development by Maslah, Hichem, Skarbek, Charles, Gourson, Catherine, Plamont, Marie‐Aude, Pethe, Stéphanie, Jullien, Ludovic, Le Saux, Thomas, Labruère, Raphaël

“…Pharmacological inactivation of antitumor drugs toward healthy cells is a critical factor in prodrug development. Typically, pharmaceutical chemists graft…”
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Arylboronate prodrugs of doxorubicin as promising chemotherapy for pancreatic cancer by Skarbek, Charles, Serra, Silvia, Maslah, Hichem, Rascol, Estelle, Labruère, Raphaël

“…[Display omitted] •Arylboronate-doxorubicin conjugates as anticancer ROS-responsive prodrugs were synthesized.•In vitro cytotoxicity of the prodrugs and…”
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Design and Validation of a Coating Mimicking the Endothelium for an Optimal Integration of Endovascular Devices by Senemaud, Jean, Skarbek, Charles, Hernandez, Belen, Song, Ran, Pan, Zhongcheng, Lefevre, Isabelle, Bianchi, Elisabetta, Nicoletti, Antonino, Bureau, Christophe, Castier, Yves, Caligiuri, Giuseppina

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Re-designing environmentally persistent pharmaceutical pollutant through programmed inactivation: The case of methotrexate by Espinosa, Anaïs, Rascol, Estelle, Abellán Flos, Marta, Skarbek, Charles, Lieben, Pascale, Bannerman, Eva, Martinez, Alba Diez, Pethe, Stéphanie, Benoit, Pierre, Nélieu, Sylvie, Labruère, Raphaël

“…Environmental emission of pharmaceutical pollutants notably causes the contamination of aquatic ecosystems and drinking water. Typically, reduction of these…”
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Photodegradation of methotrexate in aqueous solution: degradation kinetics and identification of transformation products by Espinosa, Anaïs, Nélieu, Sylvie, Lieben, Pascale, Skarbek, Charles, Labruère, Raphaël, Benoit, Pierre

“…Methotrexate is an antineoplastic folate analog of high environmental concern, due to its low biodegradability and toxicological properties. This study focused…”
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Structural modification and biological activity studies of tagitinin C and its derivatives by Au, Thi Hang, Skarbek, Charles, Pethe, Stephanie, Labruere, Raphael, Baltaze, Jean-Pierre, Nguyen, Thi Phuong Hoa, Vu, Thi Thu Ha, Vo-Thanh, Giang

“…The Michael addition reaction of amines, phosphonates and thiols to Tagitinin C containing in its structure an α-methylene-γ-lactone motif and two…”
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Development of a clot-adhesive coating to improve the performance of thrombectomy devices by Skarbek, Charles, Anagnostakou, Vania, Procopio, Emanuele, Epshtein, Mark, Raskett, Christopher M, Romagnoli, Romeo, Iviglia, Giorgio, Morra, Marco, Antonucci, Marta, Nicoletti, Antonino, Caligiuri, Giuseppina, Gounis, Matthew J

“…The first-pass complete recanalization by mechanical thrombectomy (MT) for the treatment of stroke remains limited due to the poor integration of the clot…”
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Poly-isoprenylated ifosfamide analogs: Preactivated antitumor agents as free formulation or nanoassemblies by Skarbek, Charles, Delahousse, Julia, Pioche-Durieu, Catherine, Baconnais, Sonia, Deroussent, Alain, Renevret, Patrice, Rivard, Michael, Desmaele, Didier, Martens, Thierry, Le Cam, Eric, Couvreur, Patrick, Paci, Angelo

“…[Display omitted] Oxazaphosphorines including cyclophosphamide, trofosfamide and ifosfamide (IFO) belong to the alkylating agent class and are indicated in the…”
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Abstract 2194: New oxazaphosphorine prodrugs for immunotherapy and nanomedicine against cancer by Skarbek, Charles, Gonde, Henri, Desbois, Mélanie, Delahousse, Julia, Chaput-Gras, Nathalie, Benoit, Jean-Pierre, Roger, Emilie, Paci, Angelo

“…Oxazaphosphorines (Oxaza) are widely used in the treatment of numerous cancers, activity against various tumor types, from soft tissue sarcomas to…”
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Abstract 2195: Combined strategy based on pre-activated analogs of oxazaphosphorines for increased therapeutic index and immune modulation by Delahousse, Julia, Skarbek, Charles, Gauthier, Valentine, Desbois, M, Roger, Emilie, Pioche-Durieu, C., Rivard, M., Desmaële, D., Martens, T., LeCam, E., Benoit, Jean-Pierre, Couvreur, P., Chaput-Gras, Nathalie, Paci, Angelo

“…Oxazaphosphorines (Oxaza) represented by cyclophosphamide (CPA) and ifosfamide (IFO) are still the corner stone of several polychemotherapy protocols as they…”
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In‐Cell Generation of Anticancer Phenanthridine Through Bioorthogonal Cyclization in Antitumor Prodrug Development by Maslah, Hichem, Skarbek, Charles, Gourson, Catherine, Plamont, Marie‐Aude, Pethe, Stéphanie, Jullien, Ludovic, Le Saux, Thomas, Labruère, Raphaël

“…Pharmacological inactivation of antitumor drugs toward healthy cells is a critical factor in prodrug development. Typically, pharmaceutical chemists graft…”
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Abstract 4537: Geranyloxy-ifosfamide: A pre-activated ifosfamide analogue showing an increased therapeutic index by Skarbek, Charles, Desmaele, Didier, Deroussent, Alain, Lesueur, Lea, Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Rivard, Michael, Martens, Thierry, Vassal, Gilles, Couvreur, Patrick, PACI, Angelo

“…Ifosfamide (IFO) is an alkylating agent used in routine clinical practices for treatment of cancer for many years. As a prodrug it requires cytochrome P450…”
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Simultaneous quantification of preactivated ifosfamide derivatives and of 4-hydroxyifosfamide by high performance liquid chromatography–tandem mass spectrometry in mouse plasma and its application to a pharmacokinetic study by Deroussent, Alain, Skarbek, Charles, Maury, Adeline, Chapuis, Hubert, Daudigeos-Dubus, Estelle, Le Dret, Ludivine, Durand, Sylvère, Couvreur, Patrick, Desmaële, Didier, Paci, Angelo

“…•A LC–MS/MS assay for quantification of ifosfamide conjugates and hydroxy metabolite.•The hydroxyifosfamide is stabilized as semicarbazone derivative in…”
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