Search Results - "Skandalis, Spyros S"

A guide to the composition and functions of the extracellular matrix by Karamanos, Nikos K., Theocharis, Achilleas D., Piperigkou, Zoi, Manou, Dimitra, Passi, Alberto, Skandalis, Spyros S., Vynios, Demitrios H., Orian‐Rousseau, Véronique, Ricard‐Blum, Sylvie, Schmelzer, Christian E.H., Duca, Laurent, Durbeej, Madeleine, Afratis, Nikolaos A., Troeberg, Linda, Franchi, Marco, Masola, Valentina, Onisto, Maurizio

“…Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that provides structural support for the cells and tissues. Accumulated…”
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Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production by Heldin, Paraskevi, Lin, Chun-Yu, Kolliopoulos, Constantinos, Chen, Yen-Hsu, Skandalis, Spyros S.

“…The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as well as its role in organizing tissues and cell signaling, is crucial…”
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Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer by Karousou, Evgenia, Misra, Suniti, Ghatak, Shibnath, Dobra, Katalin, Götte, Martin, Vigetti, Davide, Passi, Alberto, Karamanos, Nikos K., Skandalis, Spyros S.

“…Synthesis, deposition, and interactions of hyaluronan (HA) with its cellular receptor CD44 are crucial events that regulate the onset and progression of…”
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Hyaluronan-CD44 interactions as potential targets for cancer therapy by Misra, Suniti, Heldin, Paraskevi, Hascall, Vincent C, Karamanos, Nikos K, Skandalis, Spyros S, Markwald, Roger R, Ghatak, Shibnath

“…It is becoming increasingly clear that signals generated in tumor microenvironments are crucial to tumor cell behavior, such as survival, progression and…”
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Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors by Karalis, Theodoros T., Heldin, Paraskevi, Vynios, Demitrios H., Neill, Thomas, Buraschi, Simone, Iozzo, Renato V., Karamanos, Nikos K., Skandalis, Spyros S.

“…The malignant phenotype of various cancers is linked to enhanced expression of hyaluronan, a pro-angiogenic glycosaminoglycan whose expression is suppressed by…”
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WISP1 and Macrophage Migration Inhibitory Factor in Respiratory Inflammation: Novel Insights and Therapeutic Potentials for Asthma and COPD by Christopoulou, Maria-Elpida, Aletras, Alexios J, Papakonstantinou, Eleni, Stolz, Daiana, Skandalis, Spyros S

“…Recent advancements highlight the intricate interplay between the extracellular matrix (ECM) and immune responses, notably in respiratory diseases such as…”
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Cell–matrix interactions: focus on proteoglycan–proteinase interplay and pharmacological targeting in cancer by Theocharis, Achilleas D, Gialeli, Chrisostomi, Bouris, Panagiotis, Giannopoulou, Efstathia, Skandalis, Spyros S, Aletras, Alexios J, Iozzo, Renato V, Karamanos, Nikos K

“…Proteoglycans are major constituents of extracellular matrices, as well as cell surfaces and basement membranes. They play key roles in supporting the dynamic…”
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Serglycin: at the crossroad of inflammation and malignancy by Korpetinou, Angeliki, Skandalis, Spyros S, Labropoulou, Vassiliki T, Smirlaki, Gianna, Noulas, Argyrios, Karamanos, Nikos K, Theocharis, Achilleas D

“…Serglycin has been initially characterized as an intracellular proteoglycan expressed by hematopoietic cells. All inflammatory cells highly synthesize…”
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Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: Focus on the role and impact of proteoglycans by Skandalis, Spyros S., Afratis, Nikolaos, Smirlaki, Gianna, Nikitovic, Dragana, Theocharis, Achilleas D., Tzanakakis, George N., Karamanos, Nikos K.

“…In hormone-dependent breast cancer, estrogen receptors are the principal signaling molecules that regulate several cell functions either by the genomic pathway…”
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Cold Atmospheric Plasma Attenuates Breast Cancer Cell Growth Through Regulation of Cell Microenvironment Effectors by Aggelopoulos, Christos A, Christodoulou, Anna-Maria, Tachliabouri, Myrsini, Meropoulis, Stauros, Christopoulou, Maria-Elpida, Karalis, Theodoros T, Chatzopoulos, Athanasios, Skandalis, Spyros S

“…Breast cancer exists in multiple subtypes some of which still lack a targeted and effective therapy. Cold atmospheric plasma (CAP) has been proposed as an…”
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Serglycin is implicated in the promotion of aggressive phenotype of breast cancer cells by Korpetinou, Angeliki, Skandalis, Spyros S, Moustakas, Aristidis, Happonen, Kaisa E, Tveit, Heidi, Prydz, Kristian, Labropoulou, Vassiliki T, Giannopoulou, Efstathia, Kalofonos, Haralambos P, Blom, Anna M, Karamanos, Nikos K, Theocharis, Achilleas D

“…Serglycin is a proteoglycan expressed by some malignant cells. It promotes metastasis and protects some tumor cells from complement system attack. In the…”
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The Activity of Hyaluronan Synthase 2 Is Regulated by Dimerization and Ubiquitination by Karousou, Eugenia, Kamiryo, Masaru, Skandalis, Spyros S., Ruusala, Aino, Asteriou, Trias, Passi, Alberto, Yamashita, Hidetoshi, Hellman, Ulf, Heldin, Carl-Henrik, Heldin, Paraskevi

“…Hyaluronan is a component of the extracellular matrix, which affects tissue homeostasis. In this study, we investigated the regulatory mechanisms of one of the…”
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Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells by Karalis, Theodoros, Shiau, Andrew K, Gahman, Timothy C, Skandalis, Spyros S, Heldin, Carl-Henrik, Heldin, Paraskevi

“…Breast cancer is a common cancer in women. Breast cancer cells synthesize large amounts of hyaluronan to assist their proliferation, survival, migration and…”
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Extracellular matrix structure by Theocharis, Achilleas D., Skandalis, Spyros S., Gialeli, Chrysostomi, Karamanos, Nikos K.

“…Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network composed of collagens, proteoglycans/glycosaminoglycans, elastin,…”
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Intracellular hyaluronan: Importance for cellular functions by Skandalis, Spyros S., Karalis, Theodoros, Heldin, Paraskevi

“…Hyaluronan-rich matrices are abundant in ECM and are involved in biological processes, such as cell growth and migration. Hyaluronan is synthesized by the…”
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Advances and Advantages of Nanomedicine in the Pharmacological Targeting of Hyaluronan-CD44 Interactions and Signaling in Cancer by Skandalis, Spyros S., Gialeli, Chrisostomi, Theocharis, Achilleas D., Karamanos, Nikos K.

“…Extensive experimental evidence in cell and animal tumor models show that hyaluronan–CD44 interactions are crucial in both malignancy and resistance to cancer…”
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CD44 Intracellular Domain: A Long Tale of a Short Tail by Skandalis, Spyros S

“…CD44 is a single-chain transmembrane receptor that exists in multiple forms due to alternative mRNA splicing and post-translational modifications. CD44 is the…”
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Salicylate suppresses the oncogenic hyaluronan network in metastatic breast cancer cells by Karalis, Theodoros T., Chatzopoulos, Athanasios, Kondyli, Aikaterini, Aletras, Alexios J., Karamanos, Nikos K., Heldin, Paraskevi, Skandalis, Spyros S.

“…The oncogenic role of hyaluronan in several aspects of tumor biology has been well established. Recent studies by us and others suggest that inhibition of…”
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Hyaluronan-CD44 axis orchestrates cancer stem cell functions by Skandalis, Spyros S., Karalis, Theodoros T., Chatzopoulos, Athanasios, Karamanos, Nikos K.

“…The prominent role of CD44 in tumor cell signaling together with its establishment as a cancer stem cell (CSC) marker for various tumor entities imply a key…”
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Proteomic identification of CD44 interacting proteins by Skandalis, Spyros S., Kozlova, Inna, Engström, Ulla, Hellman, Ulf, Heldin, Paraskevi

“…CD44 is a cell surface receptor for hyaluronan which affects cell adhesion and migration, and has been implicated in chronic inflammation and in tumorigenesis…”
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