Evaluation of serial QT dispersion in patients with first non‐Q‐wave myocardial infarction: Relation to the severity of underlying coronary artery disease

Background: Increased QT dispersion (QTD) has been correlated with ventricular arrhythmias. Recent reports suggest that it may serve as a marker of the severity of underlying coronary artery disease (CAD). Hypothesis: The aim of this study was to examine in‐hospital changes of QTD and their possible...

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Published in:	Clinical cardiology (Mahwah, N.J.) Vol. 26; no. 4; pp. 189 - 195
Main Authors:	Lyras, T. G., Papapanagiotou, V. A., Foukarakis, M. G., Panou, F. K., Skampas, N. D., Lakoumentas, J. A., Priftis, C. V., Zacharoulis, A. A.
Format:	Journal Article
Language:	English
Published:	New York Wiley Periodicals, Inc 01-04-2003 Wiley
Subjects:	Biological and medical sciences Clinical Investigation Clinical Investigations Coronary Angiography coronary artery disease Coronary Disease - diagnosis Coronary Disease - physiopathology Electrocardiography Electrocardiography. Vectocardiography Electrodiagnosis. Electric activity recording Female Heart Rate Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Myocardial Infarction - physiopathology non‐Q wave myocardial infarction QT dispersion Regression Analysis Severity of Illness Index Time Factors Human coronary artery disease QT interval Infarct Pathophysiology Cardiovascular disease Exploration Myocardial disease Coronary heart disease Dispersion QT dispersion non-Q wave myocardial infarction Electrodiagnosis Electrocardiography Myocardium Severity score
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Summary:	Background: Increased QT dispersion (QTD) has been correlated with ventricular arrhythmias. Recent reports suggest that it may serve as a marker of the severity of underlying coronary artery disease (CAD). Hypothesis: The aim of this study was to examine in‐hospital changes of QTD and their possible correlation with the severity of underlying CAD in patients with first non‐Q‐wave myocardial infarction. Methods: In 62 patients we estimated QTD, precordial QTD, as well as their values corrected for heart rate on Days 3 and 7 after admission. The severity of underlying ischemic burden was estimated by means of the number of diseased vessels as well as by the jeopardy score. Results: On Day 3, patients with jeopardy score ≥ 6 exhibited greater QTD, corrected QTD, precordial QTD, and corrected precordial QTD (p = 0.001, p = 0.003, p = 0.02, p = 0.036, respectively); patients with multivessel disease had greater QTD (p = 0.007). On Day 7, patients with jeopardy score ≥6 and multivessel disease exhibited greater QTD, corrected QTD, precordial QTD, and corrected precordial QTD (p < 0.001 for all). Multiple regression analysis revealed a jeopardy score of ≥ 6 as the most significant independent predictor for QTD variables. From Days 3 to 7, only patients with none or one diseased vessel or jeopardy score < 6 had shortened QTD (p = 0.01 and p = 0.015, respectively) and corrected QTD (p < 0.001 for both). Conclusions: In patients with first non‐Q‐wave myocardial infarction, QTD variables and their in‐hospital changes reflect the severity of underlying CAD.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0160-9289 1932-8737
DOI:	10.1002/clc.4960260409