Search Results - "Skaletskaya, Anna"

SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38+ Hematologic Malignancies by DECKERT, Jutta, WETZEL, Marie-Cécile, DUMONTET, Charles, PLESA, Adriana, CHIRON, Marielle, LEJEUNE, Pascale, CHITTENDEN, Thomas, PARK, Peter U, BLANC, Véronique, BARTLE, Laura M, SKALETSKAYA, Anna, GOLDMACHER, Victor S, VALLEE, François, QING, Zhou-Liu, FERRARI, Paul, POUZIEUX, Stéphanie, LAHOUTE, Charlotte

“…The CD38 cell surface antigen is expressed in diverse hematologic malignancies including multiple myeloma, B-cell non-Hodgkin lymphoma (NHL), B-cell chronic…”
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Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates by Li, Wei, Veale, Karen H, Qiu, Qifeng, Sinkevicius, Kerstin W, Maloney, Erin K, Costoplus, Juliet A, Lau, Janet, Evans, Helen L, Setiady, Yulius, Ab, Olga, Abbott, Stephen M, Lee, Jenny, Wisitpitthaya, Somsinee, Skaletskaya, Anna, Wang, Lintao, Keating, Thomas A, Chari, Ravi V. J, Widdison, Wayne C

“…Antibody–drug conjugates (ADCs) that incorporate the exatecan derivative DXd in their payload are showing promising clinical results in solid tumor…”
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A Cytomegalovirus-Encoded Inhibitor of Apoptosis That Suppresses Caspase-8 Activation by Skaletskaya, Anna, Bartle, Laura M., Chittenden, Thomas, McCormick, A. Louise, Mocarski, Edward S., Goldmacher, Victor S.

“…We have identified a human cytomegalovirus cell-death suppressor, denoted vICA, encoded by the viral UL36 gene. vICA inhibits Fas-mediated apoptosis by binding…”
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Cytomegalovirus Cell Death Suppressor vMIA Blocks Bax- but Not Bak-Mediated Apoptosis by Binding and Sequestering Bax at Mitochondria by Arnoult, Damien, Bartle, Laura M., Skaletskaya, Anna, Poncet, Delphine, Zamzami, Naoufal, Park, Peter U., Sharpe, Juanita, Youle, Richard J., Goldmacher, Victor S., Kieff, Elliott D.

“…We report that the cytomegalovirus-encoded cell death suppressor vMIA binds Bax and prevents Bax-mediated mitochondrial membrane permeabilization by…”
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murine cytomegalovirus cell death suppressor m38.5 binds Bax and blocks Bax-mediated mitochondrial outer membrane permeabilization by Arnoult, Damien, Skaletskaya, Anna, Estaquier, Jérôme, Dufour, Cecilie, Goldmacher, Victor S

“…Apoptosis is increasingly implicated as an early line of defense against viral infections. Viruses have devised numerous strategies to delay apoptosis of…”
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A Cytomegalovirus-Encoded Mitochondria-Localized Inhibitor of Apoptosis Structurally Unrelated to Bcl-2 by Goldmacher, Victor S., Bartle, Laura M., Skaletskaya, Anna, Dionne, Cheryl A., Kedersha, Nancy L., Vater, Carol A., Han, Jia-wen, Lutz, Robert J., Watanabe, Shinya, Ellen D. Cahir Mc Farland, Kieff, Elliott D., Mocarski, Edward S., Chittenden, Thomas

“…Human cytomegalovirus (CMV), a herpesvirus that causes congenital disease and opportunistic infections in immunocompromised individuals, encodes functions that…”
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Differential function and expression of the viral inhibitor of caspase 8-induced apoptosis (vICA) and the viral mitochondria-localized inhibitor of apoptosis (vMIA) cell death suppressors conserved in primate and rodent cytomegaloviruses by McCormick, A.Louise, Skaletskaya, Anna, Barry, Peter A, Mocarski, Edward S, Goldmacher, Victor S

“…Human cytomegalovirus (CMV) genes UL36 and UL37 encode viral inhibitor of caspase-8-induced apoptosis (vICA) and viral mitochondria inhibitor of apoptosis…”
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An Anti-apoptotic Viral Protein That Recruits Bax to Mitochondria by Poncet, Delphine, Larochette, Nathanael, Pauleau, Anne-Laure, Boya, Patricia, Jalil, Abdel-Ali, Cartron, Pierre-Francois, Vallette, Francois, Schnebelen, Céline, Bartle, Laura M, Skaletskaya, Anna, Boutolleau, David, Martinou, Jean-Claude, Goldmacher, Victor S, Kroemer, Guido, Zamzami, Naoufal

“…The viral mitochondria-localized inhibitor of apoptosis (vMIA), encoded by the UL37 gene of human cytomegalovirus, inhibits apoptosis-associated mitochondrial…”
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The Sequence and Antiapoptotic Functional Domains of the Human Cytomegalovirus UL37 Exon 1 Immediate Early Protein Are Conserved in Multiple Primary Strains by Hayajneh, Wail A., Colberg-Poley, Anamaris M., Skaletskaya, Anna, Bartle, Laura M., Lesperance, Marci M., Contopoulos-Ioannidis, Despina G., Kedersha, Nancy L., Goldmacher, Victor S.

“…The human cytomegalovirus UL37 exon 1 gene encodes the immediate early protein pUL37x1 that has antiapoptotic and regulatory activities. Deletion mutagenesis…”
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ORM-6151: A First-in-Class, Anti-CD33 Antibody-Enabled GSPT1 Degrader for AML by Palacino, James, Lee, Pedro, Jeong, Hangyeol, Kim, Yeonjoon, Song, Yoojin, Permpoon, Uttapol, Wong, Wesley, Bai, Chen, Fishkin, Nathan, Takrouri, Khuloud, Yu, Eunjin, Yi, Yong, Skaletskaya, Anna, Chang, Ki-Hwan, Kim, Min-Soo, Kim, Da-Yeong, Choi, Dong-Ki, Park, Peter U

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Abstract 2186: Peptide-cleavable maytansinoid (ADCs) induce high bystander killing leading to improved anti-tumor activity in vivo by Widdison, Wayne C., Costoplus, Juliet A., Ponte, Jose F., Lanieri, Leanne, Setiady, Yulius, Dong, Ling, Skaletskaya, Anna, Wu, Rui, Qiu, Qifeng, Kovtun, Yelena, Chari, Ravi V.

“…Abstract Antibodies targeting surface antigens on cancer cells typically have progressively lower access to tumor cells that are further removed from blood…”
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A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells by Singh, Rajeeva, Setiady, Yulius Y, Ponte, Jose, Kovtun, Yelena V, Lai, Katharine C, Hong, E Erica, Fishkin, Nathan, Dong, Ling, Jones, Gregory E, Coccia, Jennifer A, Lanieri, Leanne, Veale, Karen, Costoplus, Juliet A, Skaletskaya, Anna, Gabriel, Rabih, Salomon, Paulin, Wu, Rui, Qiu, Qifeng, Erickson, Hans K, Lambert, John M, Chari, Ravi V J, Widdison, Wayne C

“…A triglycyl peptide linker (CX) was designed for use in antibody -: drug conjugates (ADC), aiming to provide efficient release and lysosomal efflux of…”
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Abstract 215: Generation of site-specific DARPin® drug conjugates using EGFR as a model system by Laviolette, Laura A., Guidi, Cynthia J., Reichen, Christian, Qiu, Qifeng, Harris, Luke, Schildknecht, Patricia, Fischer, Stefanie, Arany, Zita, Hospodarsch, Tanja, Skaletskaya, Anna, Fuller, Megan, Abbott, Stephen, McCarthy, Rebecca, Lee, Jenny, Francisco, Katherine, Sinkevicius, Kerstin, Adams, Sharlene, Espelin, Christopher, Reid, Emily, Li, Wei, Marashio, Carla, Donahue, Kerry, Hicks, Stuart, Snell, Dan

“…Abstract DARPin® molecules are small engineered proteins, derived from natural ankyrin repeat proteins that are selected to bind to specific targets with high…”
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Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing by Widdison, Wayne C, Ponte, Jose F, Coccia, Jennifer A, Lanieri, Leanne, Setiady, Yulius, Dong, Ling, Skaletskaya, Anna, Hong, E. Erica, Wu, Rui, Qiu, Qifeng, Singh, Rajeeva, Salomon, Paulin, Fishkin, Nathan, Harris, Luke, Maloney, Erin K, Kovtun, Yelena, Veale, Karen, Wilhelm, Sharon D, Audette, Charlene A, Costoplus, Juliet A, Chari, Ravi V. J

“…Antibody anilino maytansinoid conjugates (AaMCs) have been prepared in which a maytansinoid bearing an aniline group was linked through the aniline amine to a…”
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Abstract 71: Bystander activity and in vivo efficacy of a folate receptor α (FRα)-targeting antibody-drug conjugate with a novel peptide linker by Qiu, Qifeng, Wu, Rui, Lanieri, Leanne, Maloney, Erin, Skaletskaya, Anna, Jin, Shan, Wang, Lintao, Ab, Olga, Ponte, Joe, Setiady, Yulius, Widdison, Wayne, Keating, Thomas, Chari, Ravi, Gregory, Richard, Hong, Erica

“…Abstract Folate receptor α (FRα) is an antigen that is overexpressed on the cell surface of solid tumors including ovarian cancer. The differential expression…”
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Abstract 2700: ORM-6151: A first-in-class CD33-antibody enabled GSPT1 degrader for AML by Palacino, James, Lee, Pedro, Jeong, Hangyeol, Kim, Yeonjoon, Song, Yoojin, Permpoon, Uttapol, Wong, Wesley, Bai, Chen, Fishkin, Nathan, Takouri, Khuloud, Yu, Eunjun, Yi, Yong, Skaletskaya, Anna, Kim, Min-Soo, Kim, Da-Yeong, Choi, Dong-Ki, Park, Peter U.

“…Abstract Targeted protein degraders (TPDs) have expanded the breadth of therapeutic options through both their catalytic mechanism of action and ability to…”
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Abstract 2118: Development of RNAscope multiplex-based assay for exploratory pharmacodynamic biomarkers assessment in breast cancer patients from Phase I clinical trial of ORM-5029, a potent GSPT1 degrader by Saini, Shikha, Kim, Yeonjoon, Wong, Wesley, Karunaratne, Tina, Christensen, Olaf, Dutta, Sujoy, Bhar, Palash, Takrouri, Khuloud, Fishkin, Nathan, Choi, Dong-Ki, Kim, Min-Soo, Lim, Joanne, Skaletskaya, Anna, Palacino, James, Park, Peter

“…Abstract Breast cancer is the most common invasive cancer in women worldwide and remains a clinical challenge. Addressing the unmet need for better…”
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Abstract 4436: A novel antibody-enabled dual precision targeted protein stabilization (TPS2) that augments anti-tumor immune response by targeting CBL-B inhibitor to exhausted T cells while blocking checkpoint molecule, PD-1 by Lim, Joanne, Skaletskaya, Anna, Permpoon, Uttapol, Kim, Yeonjoon, Saini, Shikha, Takrouri, Khuloud, Ribkovskaia, Zinaida, Bhar, Palash, Fishkin, Nathan, Choi, Dong-Ki, Park, Ji Hyun, Palacino, James, Park, Peter U.

“…Abstract It is well-established that T cells play a key role in the success of cancer immunotherapies. The goals of T cell-targeting therapies have been to…”
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Abstract 4513: IMGN289, an EGFR-targeting antibody-drug conjugate, is effective against tumor cells that are resistant to EGFR tyrosine kinase inhibitors by Setiady, Yulius Y., Dong, Ling, Skaletskaya, Anna, Pinkas, Jan, Lutz, Robert J., Lambert, John M., Chittenden, Thomas

“…Abstract EGFR is one of the oncogenic drivers in non-small-cell lung adenocarcinoma (NSCLC AC). EGFR tyrosine kinase inhibitors (TKIs), such as erlotinib,…”
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Peptide-Cleavable Self-immolative Maytansinoid Antibody–Drug Conjugates Designed To Provide Improved Bystander Killing by Costoplus, Juliet A, Veale, Karen H, Qiu, Qifeng, Ponte, Jose F, Lanieri, Leanne, Setiady, Yulius, Dong, Ling, Skaletskaya, Anna, Bartle, Laura M, Salomon, Paulin, Wu, Rui, Maloney, Erin K, Kovtun, Yelena V, Ab, Olga, Lai, Kate, Chari, Ravi V. J, Widdison, Wayne C

“…A new type of antibody–drug conjugate (ADC) has been prepared that contains a sulfur-bearing maytansinoid attached to an antibody via a highly stable…”
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