Search Results - "Skala, C."

Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines by Capowski, Elizabeth E, Samimi, Kayvan, Mayerl, Steven J, Phillips, M Joseph, Pinilla, Isabel, Howden, Sara E, Saha, Jishnu, Jansen, Alex D, Edwards, Kimberly L, Jager, Lindsey D, Barlow, Katherine, Valiauga, Rasa, Erlichman, Zachary, Hagstrom, Anna, Sinha, Divya, Sluch, Valentin M, Chamling, Xitiz, Zack, Donald J, Skala, Melissa C, Gamm, David M

“…Numerous protocols have been described for producing neural retina from human pluripotent stem cells (hPSCs), many of which are based on the culture of 3D…”
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Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer by Nagathihalli, Nagaraj S, Castellanos, Jason A, Shi, Chanjuan, Beesetty, Yugandhar, Reyzer, Michelle L, Caprioli, Richard, Chen, Xi, Walsh, Alex J, Skala, Melissa C, Moses, Harold L, Merchant, Nipun B

“…Background & Aims A hallmark of pancreatic ductal adenocarcinoma (PDAC) is the presence of a dense desmoplastic reaction (stroma) that impedes drug delivery to…”
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Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation by Pasch, Cheri A, Favreau, Peter F, Yueh, Alexander E, Babiarz, Christopher P, Gillette, Amani A, Sharick, Joe T, Karim, Mohammad Rezaul, Nickel, Kwangok P, DeZeeuw, Alyssa K, Sprackling, Carley M, Emmerich, Philip B, DeStefanis, Rebecca A, Pitera, Rosabella T, Payne, Susan N, Korkos, Demetra P, Clipson, Linda, Walsh, Christine M, Miller, Devon, Carchman, Evie H, Burkard, Mark E, Lemmon, Kayla K, Matkowskyj, Kristina A, Newton, Michael A, Ong, Irene M, Bassetti, Michael F, Kimple, Randall J, Skala, Melissa C, Deming, Dustin A

“…Cancer treatment is limited by inaccurate predictors of patient-specific therapeutic response. Therefore, some patients are exposed to unnecessary side effects…”
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Metabolic Imaging of Head and Neck Cancer Organoids by Shah, Amy T, Heaster, Tiffany M, Skala, Melissa C

“…Head and neck cancer patients suffer from toxicities, morbidities, and mortalities, and these ailments could be minimized through improved therapies. Drug…”
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In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia by Skala, Melissa C, Riching, Kristin M, Gendron-Fitzpatrick, Annette, Eickhoff, Jens, Eliceiri, Kevin W, White, John G, Ramanujam, Nirmala

“…Metabolic imaging of the relative amounts of reduced NADH and FAD and the microenvironment of these metabolic electron carriers can be used to noninvasively…”
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Imaging retinal melanin: a review of current technologies by Lapierre-Landry, Maryse, Carroll, Joseph, Skala, Melissa C

“…The retinal pigment epithelium (RPE) is essential to the health of the retina and the proper functioning of the photoreceptors. The RPE is rich in melanosomes,…”
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Label-free imaging for quality control of cardiomyocyte differentiation by Qian, Tongcheng, Heaster, Tiffany M., Houghtaling, Angela R., Sun, Kexin, Samimi, Kayvan, Skala, Melissa C.

“…Human pluripotent stem cell (hPSC)-derived cardiomyocytes provide a promising regenerative cell therapy for cardiovascular patients and an important model…”
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Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response by Walsh, Alex J, Castellanos, Jason A, Nagathihalli, Nagaraj S, Merchant, Nipun B, Skala, Melissa C

“…Three-dimensional organoids derived from primary pancreatic ductal adenocarcinomas are an attractive platform for testing potential anticancer drugs on…”
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In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye by Lapierre-Landry, Maryse, Gordon, Andrew Y., Penn, John S., Skala, Melissa C.

“…Optical coherence tomography (OCT) has become a standard-of-care in retinal imaging. OCT allows non-invasive imaging of the tissue structure but lacks…”
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Cellular Metabolic Heterogeneity In Vivo Is Recapitulated in Tumor Organoids by Sharick, Joe T., Jeffery, Justin J., Karim, Mohammad R., Walsh, Christine M., Esbona, Karla, Cook, Rebecca S., Skala, Melissa C.

“…Heterogeneous populations within a tumor have varying metabolic profiles, which can muddle the interpretation of bulk tumor imaging studies of treatment…”
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Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model by Ayuso, Jose M., Truttschel, Regan, Gong, Max M., Humayun, Mouhita, Virumbrales-Munoz, Maria, Vitek, Ross, Felder, Mildred, Gillies, Stephen D., Sondel, Paul, Wisinski, Kari B., Patankar, Manish, Beebe, David J., Skala, Melissa C.

“…Immunotherapies against solid tumors face additional challenges compared with hematological cancers. In solid tumors, immune cells and antibodies need to…”
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In Vivo Autofluorescence Imaging of Tumor Heterogeneity in Response to Treatment by Shah, Amy T, Diggins, Kirsten E, Walsh, Alex J, Irish, Jonathan M, Skala, Melissa C

“…Abstract Subpopulations of cells that escape anti-cancer treatment can cause relapse in cancer patients. Therefore, measurements of cellular-level tumor…”
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Drug response in organoids generated from frozen primary tumor tissues by Walsh, Alex J., Cook, Rebecca S., Sanders, Melinda E., Arteaga, Carlos L., Skala, Melissa C.

“…Primary tumor organoids grown in three-dimensional culture provide an excellent platform for studying tumor progression, invasion and drug response. However,…”
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Does vaginal bacterial colonization contribute to preterm birth in women with asymptomatic shortened cervix? by Steetskamp, J., Zander, M., Laufs, V., Elger, T., Hasenburg, A., Skala, C.

“…Purpose The aim of this study is to describe the typical microbial spectrum and the influence of distinct vaginal infections on preterm birth in pregnancies…”
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Quality of life in menopausal women in the workplace - a systematic review by Theis, S., Baumgartner, S. J., Janka, H., Kolokythas, A., Skala, C., Stute, P.

“…Menopausal women are a large and economically relevant group in the workforce. Yet their quality of life (QoL) and needs in the workplace have been neglected…”
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Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment by Sharick, Joe T., Walsh, Christine M., Sprackling, Carley M., Pasch, Cheri A., Pham, Dan L., Esbona, Karla, Choudhary, Alka, Garcia-Valera, Rebeca, Burkard, Mark E., McGregor, Stephanie M., Matkowskyj, Kristina A., Parikh, Alexander A., Meszoely, Ingrid M., Kelley, Mark C., Tsai, Susan, Deming, Dustin A., Skala, Melissa C.

“…New tools are needed to match cancer patients with effective treatments. Patient-derived organoids offer a high-throughput platform to personalize treatments…”
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Optical metabolic imaging of treatment response in human head and neck squamous cell carcinoma by Shah, Amy T, Demory Beckler, Michelle, Walsh, Alex J, Jones, William P, Pohlmann, Paula R, Skala, Melissa C

“…Optical metabolic imaging measures fluorescence intensity and lifetimes from metabolic cofactors nicotinamide adenine dinucleotide (NADH) and flavin adenine…”
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Photothermal Optical Coherence Tomography of Epidermal Growth Factor Receptor in Live Cells Using Immunotargeted Gold Nanospheres by Skala, Melissa C, Crow, Matthew J, Wax, Adam, Izatt, Joseph A

“…Molecular imaging is a powerful tool for investigating disease processes and potential therapies in both in vivo and in vitro systems. However, high resolution…”
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Metabolic changes in Toxoplasma gondii -infected host cells measured by autofluorescence imaging by Gallego-López, Gina M, Contreras Guzman, Emmanuel, Desa, Danielle E, Knoll, Laura J, Skala, Melissa C

“…the causative agent of toxoplasmosis, is an obligate intracellular parasite that infects warm-blooded vertebrates across the world. In humans, seropositivity…”
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Quantitative Spatial Analysis of Metabolic Heterogeneity Across in vivo and in vitro Tumor Models by Heaster, Tiffany M, Landman, Bennett A, Skala, Melissa C

“…Metabolic preferences of tumor cells vary within a single tumor, contributing to tumor heterogeneity, drug resistance, and patient relapse. However, the…”
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