Search Results - "Skaer, Helen"

Bringing together components of the fly renal system by Denholm, Barry, Skaer, Helen

“…The function of all animal excretory systems is to rid the body of toxins and to maintain homeostatic balance. Although excretory organs in diverse animal…”
Get full text

Developmental, Molecular, and Transport Biology of Malpighian Tubules by Beyenbach, Klaus W, Skaer, Helen, Dow, Julian A.T

“…Molecular biology is reaching new depths in our understanding of the development and physiology of Malpighian tubules. In Diptera, Malpighian tubules derive…”
Get full text

Epidermal growth factor signalling controls myosin II planar polarity to orchestrate convergent extension movements during Drosophila tubulogenesis by Saxena, Aditya, Denholm, Barry, Bunt, Stephanie, Bischoff, Marcus, VijayRaghavan, Krishnaswamy, Skaer, Helen

“…Most epithelial tubes arise as small buds and elongate by regulated morphogenetic processes including oriented cell division, cell rearrangements, and changes…”
Get full text

The tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila by Denholm, Barry, Hu, Nan, Fauquier, Teddy, Caubit, Xavier, Fasano, Laurent, Skaer, Helen

“…The physiological activities of organs are underpinned by an interplay between the distinct cell types they contain. However, little is known about the genetic…”
Get full text

Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4 by Caubit, Xavier, Lye, Claire M, Martin, Elise, Coré, Nathalie, Long, David A, Vola, Christine, Jenkins, Dagan, Garratt, Alistair N, Skaer, Helen, Woolf, Adrian S, Fasano, Laurent

“…Ureteric contractions propel foetal urine from the kidney to the urinary bladder. Here, we show that mouse ureteric smooth muscle cell (SMC) precursors express…”
Get full text

Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesis by Simões, Sérgio, Denholm, Barry, Azevedo, Dulce, Sotillos, Sol, Martin, Paul, Skaer, Helen, Hombría, James Castelli-Gair, Jacinto, António

“…During development, small RhoGTPases control the precise cell shape changes and movements that underlie morphogenesis. Their activity must be tightly regulated…”
Get full text

crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis by Denholm, Barry, Brown, Stephen, Ray, Robert P, Ruiz-Gómez, Mar, Skaer, Helen, Hombría, James Castelli-Gair

“…Members of the Rho family of small GTPases are required for many of the morphogenetic processes required to shape the animal body. The activity of this family…”
Get full text

Myoblast Diversification and Ectodermal Signaling in Drosophila by Sudarsan, Vikram, Anant, Sumita, Guptan, Preeta, VijayRaghavan, K., Skaer, Helen

“…The flight muscles of Drosophila derive from myoblasts found on the third instar disc. We demonstrate that these myoblasts already show distinctive properties…”
Get full text

The Drosophila genes crumbs and stardust are involved in the biogenesis of adherens junctions by Grawe, F, Wodarz, A, Lee, B, Knust, E, Skaer, H

“…Morphogenetic movements of epithelia during development underlie the normal elaboration of the final body plan. The tissue integrity critical for these…”
Get full text

Tip Cells Act as Dynamic Cellular Anchors in the Morphogenesis of Looped Renal Tubules in Drosophila by Weavers, Helen, Skaer, Helen

“…Tissue morphogenesis involves both the sculpting of tissue shape and the positioning of tissues relative to one another in the body. Using the renal tubules of…”
Get full text

Coordinating cell fate and morphogenesis in Drosophila renal tubules by Ainsworth, Claire, Wan, Susan, Skaer, Helen

“…as an example, we explore how cell specification leads to the morphogenetic movements that underlie the generation of tissue architecture. Taking two stages of…”
Get full text

A genetic hierarchy establishes mitogenic signalling and mitotic competence in the renal tubules of Drosophila by Sudarsan, V, Pasalodos-Sanchez, S, Wan, S, Gampel, A, Skaer, H

“…Cell proliferation in the developing renal tubules of Drosophila is strikingly patterned, occurring in two phases to generate a consistent number of tubule…”
Get full text

Tip cells: Master regulators of tubulogenesis? by Weavers, Helen, Skaer, Helen

“…•Single tip cells or groups of leading cells develop at the forefront of growing tissues.•Tip cells regulate tubule growth and morphogenesis.•Tip cells develop…”
Get full text

Crumbs stabilises epithelial polarity during tissue remodelling by Campbell, Kyra, Knust, Elisabeth, Skaer, Helen

“…The apicobasal polarity of epithelia depends on the integrated activity of apical and basolateral proteins, and is essential for tissue integrity and body…”
Get full text

Simon Hugh Piper Maddrell, ScD, FRS, 1937–2020 by Skaer, Helen, O'Donnell, Michael J., Dow, Julian A. T.

Get full text

Hemocyte-Secreted Type IV Collagen Enhances BMP Signaling to Guide Renal Tubule Morphogenesis in Drosophila by Bunt, Stephanie, Hooley, Clare, Hu, Nan, Scahill, Catherine, Weavers, Helen, Skaer, Helen

“…Details of the mechanisms that determine the shape and positioning of organs in the body cavity remain largely obscure. We show that stereotypic positioning of…”
Get full text

insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm by Weavers, Helen, Prieto-Sanchez, Silvia, Grawe, Ferdinand, Garcia-Lopez, Amparo, Artero, Ruben, Wilsch-Brauninger, Michaela, Ruiz-Gomez, Mar, Skaer, Helen, Denholm, Barry

“…The nephron is the basic structural and functional unit of the vertebrate kidney. It is composed of a glomerulus, the site of ultrafiltration, and a renal…”
Get full text

Dual Origin of the Renal Tubules in Drosophila by Denholm, Barry, Sudarsan, Vikram, Pasalodos-Sanchez, Sara, Artero, Ruben, Lawrence, Peter, Maddrell, Simon, Baylies, Mary, Skaer, Helen

Get full text

Networks that link cytoskeletal regulators and diaphragm proteins underpin filtration function in Drosophila nephrocytes by Muraleedharan, Simi, Sam, Aksah, Skaer, Helen, Inamdar, Maneesha S.

“…Insect nephrocytes provide a valuable model for kidney disease, as they are structurally and functionally homologous to mammalian kidney podocytes. They…”
Get full text

Interdependence of macrophage migration and ventral nerve cord development in Drosophila embryos by Evans, Iwan R, Hu, Nan, Skaer, Helen, Wood, Will

“…During embryonic development, Drosophila macrophages (haemocytes) undergo a series of stereotypical migrations to disperse throughout the embryo. One major…”
Get full text