Search Results - "Składanowski, Andrzej"

Specific Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration by Koszałka, Patrycja, Gołuńska, Monika, Urban, Aleksandra, Stasiłojć, Grzegorz, Stanisławowski, Marcin, Majewski, Marceli, Składanowski, Andrzej C, Bigda, Jacek

“…CD73 (ecto-5'-nucleotidase), a cell surface enzyme hydrolyzing AMP to adenosine, was lately demonstrated to play a direct role in tumor progression including…”
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CD73 on B16F10 melanoma cells in CD73-deficient mice promotes tumor growth, angiogenesis, neovascularization, macrophage infiltration and metastasis by Koszałka, Patrycja, Gołuńska, Monika, Stanisławowski, Marcin, Urban, Aleksandra, Stasiłojć, Grzegorz, Majewski, Marceli, Wierzbicki, Piotr, Składanowski, Andrzej C., Bigda, Jacek

“…Ecto-5′-nucleotidase (CD73), an enzyme providing interstitial adenosine, mediates diverse physiological and pathological responses. In tumor progression, it…”
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Inhibition of CD73 stimulates the migration and invasion of B16F10 melanoma cells in vitro, but results in impaired angiogenesis and reduced melanoma growth in vivo by KOSZAŁKA, PATRYCJA, PRYSZLAK, ANNA, GOŁUŃSKA, MONIKA, KOLASA, JUSTYNA, STASIŁOJĆ, GRZEGORZ, SKŁADANOWSKI, ANDRZEJ C, BIGDA, JACEK J

“…The role of ecto-5′-nucleotidase (CD73), an enzyme providing interstitial adenosine, was investigated in B16F10 melanoma progression. Chemical inhibition of…”
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Mechanism of cytotoxic action of perfluorinated acids. I. Alteration in plasma membrane potential and intracellular pH level by KLESZCZYNSKI, Konrad, SIŁADANOWSKI, Andrzej C

“…Perfluorinated (aliphatic) acids (PFAs) and congeners have many applications in various industrial fields and household for decades. Years later they have been…”
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Mechanism of cytotoxic action of perfluorinated acids. III. Disturbance in Ca{sup 2+} homeostasis by Kleszczynski, Konrad, Skladanowski, Andrzej C.

“…The global distribution of perfluorinated acids (PFAs) in industry and in household is well known. Their increasing environmental occurrence and…”
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Analysis of structure–cytotoxicity in vitro relationship (SAR) for perfluorinated carboxylic acids by Kleszczyński, Konrad, Gardzielewski, Paweł, Mulkiewicz, Ewa, Stepnowski, Piotr, Składanowski, Andrzej C.

“…Perfluorinated carboxylic acids (PFAs) represent derivatives of naturally occurring compounds and have been widely used in various industrial fields for…”
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Induction of the multixenobiotic/multidrug resistance system in HeLa cells in response to imidazolium ionic liquids by Rusiecka, Izabela, Składanowski, Andrzej C

“…The multixenobiotic/multidrug resistance (MXR/MDR) system controls transport of foreign molecules across the plasma membrane as a preventive measure before…”
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Adenosine as a metabolic regulator of tissue function: production of adenosine by cytoplasmic 5'-nucleotidases by Borowiec, Agnieszka, Lechward, Katarzyna, Tkacz-Stachowska, Kinga, Składanowski, Andrzej C

“…Adenosine is a product of complete dephosphorylation of adenine nucleotides which takes place in various compartments of the cell. This nucleoside is a…”
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Simplex-optimized Chromatographic Resolution of Selected Ionic Liquid Cations Utilizing a Polar Reversed-Phase System by NICHTHAUSER, Joanna, PASZKIEWICZ, Monika, SKLADANOWSKI, Andrzej C., STEPNOWSKI, Piotr

“…This study reports on optimization of the RP-HPLC separation of imidazolium and pyridinium ionic liquid cations using a variable-size simplex algorithm. Under…”
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H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy by Podhorecka, Monika, Skladanowski, Andrzej, Bozko, Przemyslaw

“…Double-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to…”
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells by Lica, Jan Jakub, Wieczór, Miłosz, Grabe, Grzegorz Jan, Heldt, Mateusz, Jancz, Marta, Misiak, Majus, Gucwa, Katarzyna, Brankiewicz, Wioletta, Maciejewska, Natalia, Stupak, Anna, Bagiński, Maciej, Rolka, Krzysztof, Hellmann, Andrzej, Składanowski, Andrzej

“…Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this…”
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Mechanism of cytotoxic action of perfluorinated acids by Kleszczynski, K, Skladanowski, A C

“…Perfluorinated (aliphatic) acids (PFAs) and congeners have many applications in various industrial fields and household for decades. Years later they have been…”
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Dual, enzymatic and non-enzymatic, function of ecto-5'-nucleotidase (eN, CD73) in migration and invasion of A375 melanoma cells by Sadej, Rafal, Skladanowski, Andrzej C

“…Ecto-5'-nucleotidase (eN, CD73) mediates extracellular adenosine production from 5'-AMP. Non-enzymatic functions of eN have also been reported. The aim of the…”
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Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: Implications for drug resistance and in vitro drug screening models by Sabisz, Michal, Skladanowski, Andrzej

“…In this study, using an in vitro human tumor model, we show that non-small lung adenocarcinoma A549 cells after treatment with DNA damaging antitumor drugs…”
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FGFR2-Driven Signaling Counteracts Tamoxifen Effect on ERα-Positive Breast Cancer Cells by Turczyk, Lukasz, Kitowska, Kamila, Mieszkowska, Magdalena, Mieczkowski, Kamil, Czaplinska, Dominika, Piasecka, Dominika, Kordek, Radzisław, Skladanowski, Andrzej C., Potemski, Piotr, Romanska, Hanna M., Sadej, Rafal

“…Signaling mediated by growth factors receptors has long been suggested as one of the key factors responsible for failure of endocrine treatment in breast…”
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Mechanism of cytotoxic action of perfluorinated acids. III. Disturbance in Ca2+ homeostasis by KLESZCZYNSKI, Konrad, SKLADANOWSKI, Andrzej C

“…The global distribution of perfluorinated acids (PFAs) in industry and in household is well known. Their increasing environmental occurrence and…”
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Mechanism of cytotoxic action of perfluorinated acids II. Disruption of mitochondrial bioenergetics by KLESZCZYNSKI, Konrad, STEPNOWSKI, Piotr, SKLADANOWSKI, Andrzej C

“…PFAs and derivatives due to perfect technological properties are broadly applied in industry and consumer goods, and in consequence widely disseminated,…”
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Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors by Daśko, Mateusz, Przybyłowska, Maja, Rachon, Janusz, Masłyk, Maciej, Kubiński, Konrad, Misiak, Majus, Składanowski, Andrzej, Demkowicz, Sebastian

“…In the present work, we report convenient methods for the synthesis of 3-(4-aminophenyl)-coumarin-7-O-sulfamate derivatives N-acylated with fluorinated…”
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MET-Pyk2 Axis Mediates Acquired Resistance to FGFR Inhibition in Cancer Cells by Kitowska, Kamila, Gorska-Arcisz, Monika, Antoun, Dima, Zarczynska, Izabela, Czaplinska, Dominika, Szczepaniak, Adrian, Skladanowski, Andrzej C, Wieczorek, Maciej, Stanczak, Aleksandra, Skupinska, Monika, Sadej, Rafal

“…Deregulation of fibroblast growth factor receptors (FGFRs) signaling, as a result of amplification, chromosomal translocation, or mutations, is involved in…”
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Modulation of cellular response to anticancer treatment by caffeine: inhibition of cell cycle checkpoints, DNA repair and more by Sabisz, Michal, Skladanowski, Andrzej

“…Caffeine and other methylxanthines produce multiple physiologic effects throughout the human body, many of these effects could potentially modulate the…”
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