Search Results - "Sjogren, HO"

Expression of TGF‐β isoforms, TGF‐β receptors, and SMAD molecules at different stages of human glioma by Kjellman, Christian, Olofsson, Sabine P., Hansson, Oscar, Von Schantz, Torbjörn, Lindvall, Magnus, Nilsson, Ingar, Salford, Leif G., Sjögren, Hans‐Olov, Widegren, Bengt

“…Human gliomas express TGF‐β but, so far the expression of downstream mediators has been investigated in only a few cell lines. We have examined tissue…”
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Nitric oxide synthase inhibitor and IL-18 enhance the anti-tumor immune response of rats carrying an intrahepatic colon carcinoma by HEGARDT, Pontus, WIDEGREN, Bengt, LI LI, SJÖGREN, Barbro, KJELLMAN, Christian, SUR, Inderpreet, SJÖGREN, Hans Olov

“…The role of nitric oxide (NO) produced by adherent spleen cells in the systemic immunosuppression developing in tumor-bearing hosts was investigated. After…”
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Inhibition of the transcription factors AP-1 and NF-κB in CD4 T cells by peroxisome proliferator-activated receptor γ ligands by Wang, Ping, Anderson, Per O., Chen, Shangwu, Paulsson, Kajsa M., Sjögren, Hans-Olov, Li, Suling

“…The peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear hormone receptor superfamily, is essential for adipocyte differentiation and…”
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Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells by Li, S, Chen, S, Xu, X, Sundstedt, A, Paulsson, K M, Anderson, P, Karlsson, S, Sjögren, H O, Wang, P

“…Members of the suppressor of cytokine signaling (SOCS) family were discovered as negative regulators of cytokine signaling by inhibition of the Janus…”
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Cloning and Functional Characterization of a Subunit of the Transporter Associated with Antigen Processing by Li, Suling, Sjogren, Hans-Olov, Hellman, Ulf, Pettersson, Ralf F., Wang, Ping

“…The transporter associated with antigen processing (TAP) is essential for the transport of antigenic peptides across the membrane of the endoplasmic reticulum…”
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Assembly of tapasin-associated MHC class I in the absence of the transporter associated with antigen processing (TAP) by Paulsson, Kajsa M., Anderson, Per O., Chen, Shangwu, Sjögren, Hans-Olov, Ljunggren, Hans-Gustaf, Wang, Ping, Li, Suling

“…The assembly of MHC class I molecules is regulated by a multi-protein complex in the endoplasmic reticules (ER) termed the loading complex. Tapasin is…”
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Association of Tapasin and COPI Provides a Mechanism for the Retrograde Transport of Major Histocompatibility Complex (MHC) Class I Molecules from the Golgi Complex to the Endoplasmic Reticulum by Paulsson, Kajsa M., Kleijmeer, Monique J., Griffith, Janice, Jevon, Marc, Chen, Shangwu, Anderson, Per O., Sjögren, Hans-Olov, Li, Suling, Wang, Ping

“…Tapasin is a subunit of the transporter associated with antigen processing (TAP). It associates with the major histocompatibility complex (MHC) class I. We…”
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HERV-F(XA34) is a full-length human endogenous retrovirus expressed in placental and fetal tissues by Kjellman, Christian, Sjögren, Hans-Olov, Salford, Leif G, Widegren, Bengt

“…The complete sequence of XA34 was identified from a 107 kb genomic clone originating from the human chromosome 7q31.1-q31.3. The 7.1 kb human endogenous…”
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Tapasin Is Required for Efficient Peptide Binding to Transporter Associated with Antigen Processing by Li, Suling, Paulsson, Kajsa M., Chen, Shangwu, Sjögren, Hans-Olov, Wang, Ping

“…The transporter associated with antigen processing (TAP) binds peptides in its cytosolic part and subsequently translocates the peptides into the lumen of the…”
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Computerized Image Analysis as a Tool to Quantify Infiltrating Leukocytes: A Comparison Between High- and Low-magnification Images by Johansson, Anna C, Visse, Edward, Widegren, Bengt, Sjogren, Hans-Olov, Siesjo, Peter

“…The purpose of the present study was to establish a rapid and reproducible method for quantification of tissue-infiltrating leukocytes using computerized image…”
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Blood Pharmacokinetics of Various Monoclonal Antibodies Labeled with a New Trifunctional Chelating Reagent for Simultaneous Conjugation with 1,4,7,10-Tetraazacyclododecane-N,N′,N″,N‴-Tetraacetic Acid and Biotin before Radiolabeling by ZHONGMIN WANG, MARTENSSON, Linda, NILSSON, Rune, BENDAHL, Par-Ola, LINDGREN, Lars, OHLSSON, Tomas, SJÖGREN, Hans-Olov, STRAND, Sven-Erik, TENNVALL, Jan

“…Purpose: Knowledge of the blood pharmacokinetics of monoclonal antibodies is crucial in deciding the optimal time for starting the administration of a…”
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Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats by SJÖGREN, H. O, ISAKSSON, M, WILLNER, D, HELLSTRÖM, I, HELLSTRÖM, K. E, TRAIL, P. A

“…The internalizing monoclonal antibody BR96 was conjugated to the anticancer drug doxorubicin (DOX) using an acid-labile hydrazone bond to DOX and a thioether…”
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Transforming growth factor- beta 1, a strong costimulator of rat T-cell activation promoting a shift towards a Th2-like cytokine profile by Schiott, A, Widegren, B, Sjogren, HO, Lindvall, M

“…TGF- beta is a known regulator of hematopoietic cells. In this study we suggest a major role of adherent spleen cells (adh-splc), to convert an inhibitory…”
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Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma, interleukin-7, or B7-1-transfected tumor cells by Visse, E, Siesjö, P, Widegren, B, Sjögren, H O

“…Progress in the definition of the roles of various costimulators and cytokines in determining the type and height of immune responses has made it important to…”
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Nitric-Oxide-Dependent Systemic Immunosuppression in Animals with Progressively Growing Malignant Gliomas by Hegardt, Pontus, Widegren, Bengt, Sjögren, Hans-Olov

“…The role of nitric oxide (NO) and adherent spleen cells in systemic immunosuppression developing in animals carrying malignant glioma isografts was analyzed…”
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Binding of staphylococcal enterotoxin A to accessory cells is a requirement for its ability to activate human T cells by Carlsson, R, Fischer, H, Sjogren, HO

“…Staphylococcal enterotoxin A (SEA) activates human T cells at extremely low concentrations corresponding to 1 to 5 molecules/T cell. SEA, in contrast to other…”
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T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles by Wingren, A G, Parra, E, Varga, M, Kalland, T, Sjögren, H O, Hedlund, G, Dohlsten, M

“…Two signals are required for induction of cell proliferation and cytokine production in resting T cells. Occupancy of the T cell receptor by antigen/MHC…”
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Peptide-bound Major Histocompatibility Complex Class I Molecules Associate with Tapasin before Dissociation from Transporter Associated with Antigen Processing by Li, S, Paulsson, K M, Sjögren, H O, Wang, P

“…Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8 T cells. The peptides are generated in the cytosol, then…”
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Association of decreased phosphorylation of ERK-2 with costimulation of rat T cell activation by MEK-1 inhibitors and TGF- beta 1 by Schiott, A, Sjogren, HO, Lindvall, M

“…Transforming growth factor- beta (TGF- beta ) is usually known as an immunosuppressive cytokine, but we and others have shown stimulatory effects of TGF- beta…”
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Vaccination with B16 melanoma cells expressing a secreted form of interleukin-1β induces tumor growth inhibition and an enhanced immunity against the wild-type B16 tumor by Björkdahl, Olle, Dohlsten, Mikael, Sjögren, Hans-Olov

“…We have demonstrated previously that gene transfer of the mature human interleukin-1β (IL-1β) gene, fused to a signal sequence (ss), into mouse B16 melanoma…”
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