Search Results - "Sjoerdsma, A"

Eflornithine for African sleeping sickness by Sjoerdsma, Albert, Schechter, Paul J

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Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor by BACCHI, C. J, NATHAN, H. C, YARLETT, N, GOLDBERG, B, MCCANN, P. P, BITONTI, A. J, SJOERDSMA, A

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Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase by Bitonti, A J, Byers, T L, Bush, T L, Casara, P J, Bacchi, C J, Clarkson, Jr, A B, McCann, P P, Sjoerdsma, A

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Polyamine Metabolism: A Potential Therapeutic Target in Trypanosomes by Bacchi, C. J., Nathan, H. C., Hutner, S. H., McCann, P. P., Sjoerdsma, A.

“…α-Difluoromethylornithine (RMI 71, 782), a specific irreversible inhibitor of the first step in polyamine biosynthesis, that is, the formation of putrescine…”
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Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides by BACCHI, C. J, NATHAN, H. C, YARLETT, N, GOLDBERG, B, MCCANN, P. P, SJOERDSMA, A, SARIC, M, CLARKSON, A. B

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Bis(benzyl)polyamine Analogs Inhibit the Growth of Chloroquine-Resistant Human Malaria Parasites (Plasmodium falciparum) in vitro and in Combination with α -difluoromethylornithine Cure Murine Malaria by Bitonti, Alan J., Dumont, Jennifer A., Bush, Tammy L., Edwards, Michael L., Stemerick, David M., McCann, Peter P., Sjoerdsma, Albert

“…A number of bis(benzyl)polyamine analogs were found to be potent inhibitors of both chloroquine-resistant and chloroquine-sensitive strains of the human…”
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Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis by Abeloff, M D, Slavik, M, Luk, G D, Griffin, C A, Hermann, J, Blanc, O, Sjoerdsma, A, Baylin, S B

“…alpha-Difluoromethylornithine (DFMO), an enzyme-activated, irreversible inhibitor of ornithine decarboxylase, blocks polyamine biosynthesis and has antitumor…”
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Methyldopa by Sjoerdsma, A

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Arginine Decarboxylase Inhibitors Reduce the Capacity of Trypanosoma cruzi to Infect and Multiply in Mammalian Host Cells by Kierszenbaum, Felipe, Wirth, Julia J., McCann, Peter P., Sjoerdsma, Albert

“…The capacity of blood (trypomastigote) forms of Trypanosoma cruzi to infect mouse peritoneal macrophages or rat heart myoblasts in vitro was inhibited by…”
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Suppression of both antimony-susceptible and antimony-resistant Leishmania donovani by a bis(benzyl)polyamine analog by BAUMANN, R. J, HANSON, W. L, MCCANN, P. P, SJOERDSMA, A, BITONTI, A. J

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L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis by Fozard, J R, Part, M L, Prakash, N J, Grove, J, Schechter, P J, Sjoerdsma, A, Koch-Weser, J

“…The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in…”
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Antimalarial polyamine analogs by Edwards, Michael L, Stemerick, D. M, Bitonti, A. J, Dumont, J. A, McCann, P. P, Bey, P, Sjoerdsma, A

“…A series of novel tetraamines of the general formula RNH(CH2)xNH(CH2)yNH(CH2)xNHR was synthesized and examined for activity against growth of Plasmodium…”
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Impairment of macrophage function by inhibitors of ornithine decarboxylase activity by KIERSZENBAUM, F, WIRTH, J. J, MCCANN, P. P, SJOERDSMA, A

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Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-alpha-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial by Van Nieuwenhove, S, Schechter, P J, Declercq, J, Boné, G, Burke, J, Sjoerdsma, A

“…Difluoromethylornithine (DFMO), a specific, irreversible inhibitor of polyamine biosynthesis shown to be curative in animal models inoculated with various…”
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Catecholamine-drug interactions in man by Sjoerdsma, A

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The effect of 4-amino hex-5-ynoic acid (gamma-acetylenic GABA, gammma-ethynyl GABA) a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivo by Jung, M J, Lippert, B, Metcalf, B W, Schechter, P J, Böhlen, P, Sjoerdsma, A

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Restriction of bacterial growth by inhibition of polyamine biosynthesis by using monofluoromethylornithine, difluoromethylarginine and dicyclohexylammonium sulphate by Bitonti, A J, McCann, P P, Sjoerdsma, A

“…Bacterial growth was measurably slowed by a combination of drugs which inhibit polyamine-biosynthetic enzymes. Addition of DL-alpha-monofluoromethylornithine,…”
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CHEMOTHERAPY OF HYPERTENSION: YESTERDAY--TODAY--TOMORROW by SJOERDSMA, A

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Antitumor activity of norspermidine, a structural homologue of the natural polyamine spermidine by Prakash, N J, Bowlin, T L, Davis, G F, Sunkara, P S, Sjoerdsma, A

“…The structural specificities of the natural polyamines putrescine (Put), spermidine (Spd) and spermine (Spm) for cell growth are rather stringent, suggesting…”
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Enzyme-activated/mechanism-based inhibitors by Palfreyman, M G, Bey, P, Sjoerdsma, A

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