Search Results - "Sjaarda, Calvin"

Honey glycoproteins containing antimicrobial peptides, Jelleins of the Major Royal Jelly Protein 1, are responsible for the cell wall lytic and bactericidal activities of honey by Brudzynski, Katrina, Sjaarda, Calvin

“…We have recently identified the bacterial cell wall as the cellular target for honey antibacterial compounds; however, the chemical nature of these compounds…”
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Colloidal structure of honey and its influence on antibacterial activity by Brudzynski, Katrina, Sjaarda, Calvin P.

“…Honey colloidal structure emerges as a new trend in research on honey functions since it became recognized as a major factor altering bioactivity of honey…”
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Antibacterial compounds of Canadian honeys target bacterial cell wall inducing phenotype changes, growth inhibition and cell lysis that resemble action of β-lactam antibiotics by Brudzynski, Katrina, Sjaarda, Calvin

“…Honeys show a desirable broad spectrum activity against Gram-positive and negative bacteria making antibacterial activity an intrinsic property of honey and a…”
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Active macromolecules of honey form colloidal particles essential for honey antibacterial activity and hydrogen peroxide production by Brudzynski, Katrina, Miotto, Danielle, Kim, Linda, Sjaarda, Calvin, Maldonado-Alvarez, Liset, Fukś, Henryk

“…Little is known about the global structure of honey and the arrangement of its main macromolecules. We hypothesized that the conditions in ripened honeys…”
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Evaluation of 5 Polymerase Chain Reaction Assays for the Detection of Mpox Virus by Fattouh, Ramzi, Boissinot, Karel, Jeong, Esther, Mendlowitz, Andrew B, Sjaarda, Calvin P, Wong, Henry, Kozak, Robert, Sheth, Prameet M, Matukas, Larissa M

“…In 2022, the global dissemination of mpox virus (MPXV) outside endemic regions prompted the expansion of diagnostic testing worldwide. This study assesses the…”
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Loss-of-function mutations in TDRD7 lead to a rare novel syndrome combining congenital cataract and nonobstructive azoospermia in humans by Tan, Yue-Qiu, Tu, Chaofeng, Meng, Lanlan, Yuan, Shimin, Sjaarda, Calvin, Luo, Aixiang, Du, Juan, Li, Wen, Gong, Fei, Zhong, Changgao, Deng, Han-Xiang, Lu, Guangxiu, Liang, Ping, Lin, Ge

“…Purpose Comorbid familial nonobstructive azoospermia (NOA) and congenital cataract (CC) have not been reported previously, and no single human gene has been…”
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A new look on protein-polyphenol complexation during honey storage: is this a random or organized event with the help of dirigent-like proteins? by Brudzynski, Katrina, Sjaarda, Calvin, Maldonado-Alvarez, Liset

“…Honey storage initiates melanoidin formation that involves a cascade of seemingly unguided redox reactions between amino acids/proteins, reducing sugars and…”
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Emergence of a mutation in the nucleocapsid gene of SARS-CoV-2 interferes with PCR detection in Canada by Isabel, Sandra, Abdulnoor, Mariana, Boissinot, Karel, Isabel, Marc R., de Borja, Richard, Zuzarte, Philip C., Sjaarda, Calvin P., R. Barker, Kevin, Sheth, Prameet M., Matukas, Larissa M., Gubbay, Jonathan B., McGeer, Allison J., Mubareka, Samira, Simpson, Jared T., Fattouh, Ramzi

“…The emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) was met with rapid development of robust molecular-based detection assays. Many…”
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Author Correction: A one-step tRNA-CRISPR system for genome-wide genetic interaction mapping in mammalian cells by Zhao, Yulei, Tyrishkin, Kathrin, Sjaarda, Calvin, Khanal, Prem, Stafford, Jeff, Rauh, Michael, Liu, Xudong, Babak, Tomas, Yang, Xiaolong

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Broad-Spectrum Inhibitor of Bacterial Polyphosphate Homeostasis Attenuates Virulence Factors and Helps Reveal Novel Physiology of Klebsiella pneumoniae and Acinetobacter baumannii by Roberge, Nathan, Neville, Nolan, Douchant, Katya, Noordhof, Curtis, Boev, Nadejda, Sjaarda, Calvin, Sheth, Prameet M., Jia, Zongchao

“…Acinetobacter baumannii and Klebsiella pneumoniae currently rank amongst the most antibiotic-resistant pathogens, responsible for millions of infections each…”
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Exome sequencing identifies de novo splicing variant in XRCC6 in sporadic case of autism by Sjaarda, Calvin P, Wood, Shalandra, McNaughton, Amy J M, Taylor, Sarah, Hudson, Melissa L, Liu, Xudong, Guerin, Andrea, Ayub, Muhammad

“…Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with heterogeneity in presentation, genetic etiology, and clinical outcome. Although…”
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Phylogenomics reveals viral sources, transmission, and potential superinfection in early-stage COVID-19 patients in Ontario, Canada by Sjaarda, Calvin P., Rustom, Nazneen, Evans, Gerald A., Huang, David, Perez-Patrigeon, Santiago, Hudson, Melissa L., Wong, Henry, Sun, Zhengxin, Guan, T. Hugh, Ayub, Muhammad, Soares, Claudio N., Colautti, Robert I., Sheth, Prameet M.

“…The emergence and rapid global spread of SARS-CoV-2 demonstrates the importance of infectious disease surveillance, particularly during the early stages. Viral…”
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Interplay between maternal Slc6a4 mutation and prenatal stress: a possible mechanism for autistic behavior development by Sjaarda, Calvin P., Hecht, Patrick, McNaughton, Amy J. M., Zhou, Audrina, Hudson, Melissa L., Will, Matt J., Smith, Garth, Ayub, Muhammad, Liang, Ping, Chen, Nansheng, Beversdorf, David, Liu, Xudong

“…The low activity allele of the maternal polymorphism, 5HTTLPR, in the serotonin transporter, SLC6A4 , coupled with prenatal stress is reported to increase the…”
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Author Correction: Emergence of a mutation in the nucleocapsid gene of SARS-CoV-2 interferes with PCR detection in Canada by Isabel, Sandra, Abdulnoor, Mariana, Boissinot, Karel, Isabel, Marc R., de Borja, Richard, Zuzarte, Philip C., Sjaarda, Calvin P., Barker, Kevin R., Sheth, Prameet M., Matukas, Larissa M., Gubbay, Jonathan B., McGeer, Allison J., Mubareka, Samira, Simpson, Jared T., Fattouh, Ramzi

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Small-molecule metabolome identifies potential therapeutic targets against COVID-19 by Bennet, Sean, Kaufmann, Martin, Takami, Kaede, Sjaarda, Calvin, Douchant, Katya, Moslinger, Emily, Wong, Henry, Reed, David E., Ellis, Anne K., Vanner, Stephen, Colautti, Robert I., Sheth, Prameet M.

“…Respiratory viruses are transmitted and acquired via the nasal mucosa, and thereby may influence the nasal metabolome composed of biochemical products produced…”
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Previous infection with seasonal coronaviruses does not protect male Syrian hamsters from challenge with SARS-CoV-2 by Francis, Magen E., Jansen, Ethan B., Yourkowski, Anthony, Selim, Alaa, Swan, Cynthia L., MacPhee, Brian K., Thivierge, Brittany, Buchanan, Rachelle, Lavender, Kerry J., Darbellay, Joseph, Rogers, Matthew B., Lew, Jocelyne, Gerdts, Volker, Falzarano, Darryl, Skowronski, Danuta M., Sjaarda, Calvin, Kelvin, Alyson A.

“…SARS-CoV-2 variants and seasonal coronaviruses continue to cause disease and coronaviruses in the animal reservoir pose a constant spillover threat…”
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P656: Improved diagnostic paradigm using optical genome mapping (OGM) for cytogenomic testing for recurrent pregnancy loss and infertility by Crocker, Susan, Guerin, Andrea, Wong, Henry, Sjaarda, Calvin, Velez, Maria, Argiropoulos, Bob, Alliston, Kate

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Induction of lcc2 expression and activity by Agaricus bisporus provides defence against Trichoderma aggressivum toxic extracts by Sjaarda, Calvin P., Abubaker, Kamal S., Castle, Alan J.

“…Summary Laccases are used by fungi for several functions including defence responses to stresses associated with attack by other fungi. Laccase activity…”
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Comparison of SARS-CoV-2 Viral Loads in the Nasal Mucosa of Patients Infected With BA.1, BA.2, or BA.5 Omicron Lineages by Tozer, Kyla, Sjaarda, Calvin P, Moslinger, Emily, Wong, Henry, Mubareka, Samira, Maguire, Finlay, Fattouh, Ramzi, Brabant-Kirwan, Danielle, Kozak, Robert, Sheth, Prameet M

“…Abstract Lower viral loads were observed in the upper respiratory tract of patients infected with BA.1, whereas patients infected with BA.2 and BA.5 had…”
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Prevalence of Low-Frequency, Antiviral Resistance Variants in SARS-CoV-2 Isolates in Ontario, Canada, 2020-2023 by Sjaarda, Calvin P, Lau, Lynette, Simpson, Jared T, Fattouh, Ramzi, Biondi, Mia J, Maguire, Finlay, Campigotto, Aaron, Feng, Yujia, Tozer, Kyla, Wong, Henry, Sung, Wilson W L, Kim, Sean, Marshall, Christian R, Sheth, Prameet M, Kozak, Robert

“…Nirmatrelvir-ritonavir is an oral antiviral medication that improves outcomes in SARS-CoV-2 infections. However, there is concern that antiviral resistance…”
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