Search Results - "Sjövall, J."

Mandibulotomy access to tumour sites: fewer complications for postoperative compared with preoperative radiotherapy by Carlwig, K., Fransson, P., Bengtsson, M., Gebre-Medhin, M., Sjövall, J., Greiff, L.

“…The purpose of this study was to compare complication rates at the mandibulotomy site between patients receiving preoperative radiotherapy (RT) and those…”
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Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers by Knudsen, K, Beckman Suurküla, M, Blomberg, S, Sjövall, J, Edvardsson, N

“…We have compared the incidence of CNS symptoms and changes in echocardiography and electrophysiology during i.v. infusions of ropivacaine, bupivacaine and…”
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Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain by de Urquiza, Alexander Mata, Liu, Suya, Sjöberg, Maria, Zetterström, Rolf H., Griffiths, William, Sjövall, Jan, Perlmann, Thomas

“…The retinoid X receptor (RXR) is a nuclear receptor that functions as a ligand-activated transcription factor. Little is known about the ligands that activate…”
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Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions by Tollin, M, Bergsson, G, Kai-Larsen, Y, Lengqvist, J, Sjövall, J, Griffiths, W, Skúladóttir, G V, Haraldsson, A, Jörnvall, H, Gudmundsson, G H, Agerberth, B

“…Vernix caseosa is a white cream-like substance that covers the skin of the foetus and the newborn baby. Recently, we discovered antimicrobial peptides/proteins…”
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Pharmacokinetics of ropivacaine in patients with chronic renal failure by Pere, P.J., Ekstrand, A., Salonen, M., Honkanen, E., Sjövall, J., Henriksson, J., Rosenberg, P.H.

“…As ropivacaine and its metabolites are excreted by the kidneys, we studied their disposition in subjects with renal dysfunction. Twenty patients with moderate…”
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Fxr[superscript -/-] mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids by Marschall, Hanns-Ulrich, Wagner, Martin, Bodin, Karl, Zollner, Gernot, Fickert, Peter, Gumhold, Judith, Silbert, Dagmar, Fuchsbichler, Andrea, Sjovall, Jan, Trauner, Michael

“…Farnesoid X receptor knockout (Fxr[superscript -/-]) mice cannot upregulate the bile salt export pump in bile acid loading or cholestatic conditions. To…”
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Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain by Liere, Philippe, Pianos, Antoine, Eychenne, Bernard, Cambourg, Annie, Liu, Suya, Griffiths, William, Schumacher, Michael, Sjövall, Jan, Baulieu, Etienne-Emile

“…A new sample preparation method coupled to GC-MS analysis was developed and validated for quantification of sulfate esters of pregnenolone (PREG-S) and…”
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Bile acids: analysis in biological fluids and tissues by Griffiths, W. J., Sjovall, J.

“…The formation of bile acids/bile alcohols is of major importance for the maintenance of cholesterol homeostasis. Besides their functions in lipid absorption,…”
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Population pharmacokinetic analysis of ropivacaine and its metabolite 2′,6′-pipecoloxylidide from pooled data in neonates, infants, and children by Aarons, L., Sadler, B., Pitsiu, M., Sjövall, J., Henriksson, J., Molnár, V.

“…The aim was to characterize ropivacaine and 2′,6′-pipecoloxylidide (PPX) pharmacokinetics and factors affecting them in paediatric anaesthesia. Population…”
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Neurosteroids: 3 alpha-hydroxy-5 alpha-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats by Corpéchot, C, Young, J, Calvel, M, Wehrey, C, Veltz, J N, Touyer, G, Mouren, M, Prasad, V V, Banner, C, Sjövall, J

“…A RIA procedure for measuring progesterone (PROG), 5 alpha-pregnane-3,20-dione (5 alpha-DH PROG), and 3 alpha-hydroxy-5 alpha-pregnan-20-one (3 alpha,5…”
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Fifty years with bile acids and steroids in health and disease by Sjovall, J

“…Cholesterol and its metabolites, e.g., steroid hormones and bile acids, constitute a class of compounds of great biological importance. Their chemistry,…”
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Levels of 7α-hydroxy-4-cholesten-3-one in plasma reflect rates of bile acid synthesis in man by Axelson, M., Aly, A., Sjövall, J.

“…A method for analysis of 7α-hydroxy-4-cholesten-3-one in plasma is described. Following solid-phase extraction/purification the compound is determined by…”
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Potential bile acid precursors in plasma--possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in man by Axelson, M, Sjövall, J

“…The plasma concentrations of 3 beta-hydroxy-5-cholestenoic acid, 3 beta,7 alpha-dihydroxy-5-cholestenoic acid and 7 alpha-hydroxy-3-oxo-4-cholestenoic acid…”
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Increase of deoxycholate in supersaturated bile of patients with cholesterol gallstone disease and its correlation with de novo syntheses of cholesterol and bile acids in liver, gallbladder emptying, and small intestinal transit by Shoda, J, He, B F, Tanaka, N, Matsuzaki, Y, Osuga, T, Yamamori, S, Miyazaki, H, Sjövall, J

“…A total of 100 nonobese and normolipidemic subjects (29 control subjects, 49 patients with cholesterol stones [CSs], and 22 patients with brown pigment stones)…”
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OC-0431 Tumour volume in oropharyngeal cancers – more important than ever by Adrian, G., Carlsson, H., Kjellén, E., Sjövall, J., Zackrisson, B., Nilsson, P., Gebre-Medhin, M.

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A systematic analytical chemistry/cell assay approach to isolate activators of orphan nuclear receptors from biological extracts : characterization of peroxisome proliferator-activated receptor activators in plasma by BANNER, C. D, GÖTTLICHER, M, WIDMARK, E, SJÖVALL, J, RAFTER, J. J, GUSTAFSSON, J.-Å

“…Using a novel combination of analytical chemical and molecular biological techniques, lipophilic components of human plasma separated according to their…”
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Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain by Lengqvist, Johan, Mata De Urquiza, Alexander, Bergman, Ann-Charlotte, Willson, Timothy M, Sjövall, Jan, Perlmann, Thomas, Griffiths, William J

“…Nuclear receptors (NRs) constitute a large and highly conserved family of ligand-activated transcription factors that regulate diverse biological processes…”
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Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy by Reyes, H, Sjövall, J

“…The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) can be related to abnormalities in the metabolism and disposition of sex hormones and/or bile…”
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Cholestatic liver disease in adults may be due to an inherited defect in bile acid biosynthesis by Fischler, B., Bodin, K., Stjernman, H., Olin, M., Hansson, M., Sjövall, J., Björkhem, I.

“… Background.  An increasing number of treatable inborn errors of bile acid synthesis have been described, primarily in infants with severe cholestatic liver…”
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Ring Opening of Benzo[a]pyrene in the Germ-Free Rat Is a Novel Pathway for Formation of Potentially Genotoxic Metabolites by Yang, Griffiths, William J, Nordling, Mirjam, Nygren, Jonas, Möller, Lennart, Bergman, Jan, Liepinsh, Edvards, Otting, Gottfried, Gustafsson, Jan-Åke, Rafter, Joseph, Sjövall, Jan

“…The metabolism of benzo[a]pyrene (BP) is known to lead to a large number of oxygenated compounds, some of which can bind covalently to DNA. We have studied the…”
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