Search Results - "Sjögren, Klara"

Effects of the gut microbiota on bone mass by Ohlsson, Claes, Sjögren, Klara

“…Highlights • Studies in germ-free (GF) mice demonstrate that the gut microbiota (GM) is a regulator of bone mass. • The GM affects bone mass via effects on the…”
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Osteomicrobiology: A New Cross-Disciplinary Research Field by Ohlsson, Claes, Sjögren, Klara

“…The mutualistic interaction between the gut microbiota (GM) and its host profoundly shapes many aspects of our physiology. The composition and activity of the…”
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The Role of Liver-Derived Insulin-Like Growth Factor-I by Ohlsson, Claes, Mohan, Subburaman, Sjögren, Klara, Tivesten, Åsa, Isgaard, Jörgen, Isaksson, Olle, Jansson, John-Olov, Svensson, Johan

“…IGF-I is expressed in virtually every tissue of the body, but with much higher expression in the liver than in any other tissue. Studies using mice with…”
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The gut microbiota is a major regulator of androgen metabolism in intestinal contents by Colldén, Hannah, Landin, Andreas, Wallenius, Ville, Elebring, Erik, Fändriks, Lars, Nilsson, Maria E, Ryberg, Henrik, Poutanen, Matti, Sjögren, Klara, Vandenput, Liesbeth, Ohlsson, Claes

“…Androgens exert important effects both in androgen-responsive tissues and in the intestinal tract. To determine the impact of the gut microbiota (GM) on…”
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Probiotics protect mice from ovariectomy-induced cortical bone loss by Ohlsson, Claes, Engdahl, Cecilia, Fåk, Frida, Andersson, Annica, Windahl, Sara H, Farman, Helen H, Movérare-Skrtic, Sofia, Islander, Ulrika, Sjögren, Klara

“…The gut microbiota (GM) modulates the hosts metabolism and immune system. Probiotic bacteria are defined as live microorganisms which when administered in…”
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The gut microbiota regulates bone mass in mice by Sjögren, Klara, Engdahl, Cecilia, Henning, Petra, Lerner, Ulf H, Tremaroli, Valentina, Lagerquist, Marie K, Bäckhed, Fredrik, Ohlsson, Claes

“…The gut microbiota modulates host metabolism and development of immune status. Here we show that the gut microbiota is also a major regulator of bone mass in…”
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Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice by Ohlsson, Claes, Henning, Petra, Nilsson, Karin H, Wu, Jianyao, Gustafsson, Karin L, Sjögren, Klara, Törnqvist, Anna, Koskela, Antti, Zhang, Fu-Ping, Lagerquist, Marie K, Poutanen, Matti, Tuukkanen, Juha, Lerner, Ulf H, Movérare-Skrtic, Sofia

“…Substantial progress has been made in the therapeutic reduction of vertebral fracture risk in patients with osteoporosis, but non-vertebral fracture risk has…”
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Acute fat loss does not affect bone mass by Lagerquist, Marie K., Gustafsson, Karin L., Henning, Petra, Farman, Helen, Wu, Jianyao, Sjögren, Klara, Koskela, Antti, Tuukkanen, Juha, Ohlsson, Claes, Wernstedt Asterholm, Ingrid, Grahnemo, Louise

“…Obesity has previously been thought to protect bone since high body weight and body mass index are associated with high bone mass. However, some more recent…”
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GREM2 inactivation increases trabecular bone mass in mice by Nilsson, Karin H., Henning, Petra, Wu, Jianyao, Sjögren, Klara, Lerner, Ulf H., Ohlsson, Claes, Movérare-Skrtic, Sofia

“…Osteoporosis is a common skeletal disease affecting millions of individuals world-wide, with an increased risk of fracture, and a decreased quality of life…”
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Regulation of bone mass by the gut microbiota is dependent on NOD1 and NOD2 signaling by Ohlsson, Claes, Nigro, Giulia, Boneca, Ivo Gomperts, Bäckhed, Fredrik, Sansonetti, Philippe, Sjögren, Klara

“…•MYD88, NOD1 and NOD2, are involved in bacterial recognition by the immune system.•WT and MYD88 deficient mice have increased bone mass when raised germ free…”
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The androgen receptor is required for maintenance of bone mass in adult male mice by Wu, Jianyao, Henning, Petra, Sjögren, Klara, Koskela, Antti, Tuukkanen, Juha, Movérare-Skrtic, Sofia, Ohlsson, Claes

“…Previous studies evaluating the role of the androgen receptor (AR) for bone mass have used mouse models with global or tissue-specific lifelong inactivation of…”
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A probiotic mix partially protects against castration-induced bone loss in male mice by Lawenius, Lina, Colldén, Hannah, Horkeby, Karin, Wu, Jianyao, Grahnemo, Louise, Vandenput, Liesbeth, Ohlsson, Claes, Sjögren, Klara

“…Studies in postmenopausal women and ovariectomized mice show that the probiotic mix Lacticaseibacillus paracasei DSM13434, Lactiplantibacillus plantarum DSM…”
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Mild stimulatory effect of a probiotic mix on bone mass when treatment is initiated 1.5 weeks after ovariectomy in mice by Ohlsson, Claes, Lawenius, Lina, Andersson, Annica, Gustafsson, Karin, Wu, Jianyao, Lagerquist, Marie, Movérare-Skrtic, Sofia, Islander, Ulrika, Sjögren, Klara

“…Studies in humans and rodents show that probiotic bacteria can protect from bone loss caused by sex steroid deficiency. We showed earlier that a mixture of…”
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Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment in male mice by Horkeby, Karin, Farman, Helen H., Movérare-Skrtic, Sofia, Lionikaite, Vikte, Wu, Jianyao, Henning, Petra, Windahl, Sara, Sjögren, Klara, Ohlsson, Claes, Lagerquist, Marie K.

“…Estrogen receptor alpha (ERα) signaling has beneficial skeletal effects in males. ERα signaling also affects other tissues, and to find bone-specific…”
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estrogen receptor antagonist ICI 182,780 can act both as an agonist and an inverse agonist when estrogen receptor α AF-2 is modified by Movérare-Skrtic, Sofia, Börjesson, Anna E., Farman, Helen H., Sjögren, Klara, Windahl, Sara H., Lagerquist, Marie K., Andersson, Annica, Stubelius, Alexandra, Carlsten, Hans, Gustafsson, Jan-Åke, Ohlsson, Claes

“…The bone-sparing effect of estrogen is primarily mediated via estrogen receptor (ER) α, which stimulates target gene transcription through two activation…”
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Liver-derived IGF-I regulates mean life span in mice by Svensson, Johan, Sjögren, Klara, Fäldt, Jenny, Andersson, Niklas, Isaksson, Olle, Jansson, John-Olov, Ohlsson, Claes

“…Transgenic mice with low levels of global insulin-like growth factor-I (IGF-I) throughout their life span, including pre- and postnatal development, have…”
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Transplantation of gut microbiota from old mice into young healthy mice reduces lean mass but not bone mass by Lawenius, Lina, Cowardin, Carrie, Grahnemo, Louise, Scheffler, Julia M., Horkeby, Karin, Engdahl, Cecilia, Wu, Jianyao, Vandenput, Liesbeth, Koskela, Antti, Tuukkanen, Juha, Coward, Eivind, Hveem, Kristian, Langhammer, Arnulf, Abrahamsson, Sanna, Gordon, Jeffrey I., Sjögren, Klara, Ohlsson, Claes

“…Aging is associated with low bone and lean mass as well as alterations in the gut microbiota (GM). In this study, we determined whether the reduced bone mass…”
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Liver-derived IGF-I regulates cortical bone mass but is dispensable for the osteogenic response to mechanical loading in female mice by Svensson, Johan, Windahl, Sara H, Saxon, Leanne, Sjögren, Klara, Koskela, Antti, Tuukkanen, Juha, Ohlsson, Claes

“…Low circulating IGF-I is associated with increased fracture risk. Conditional depletion of IGF-I produced in osteoblasts or osteocytes inhibits the bone…”
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Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated mice by Windahl, Sara H, Andersson, Niklas, Börjesson, Anna E, Swanson, Charlotte, Svensson, Johan, Movérare-Skrtic, Sofia, Sjögren, Klara, Shao, Ruijin, Lagerquist, Marie K, Ohlsson, Claes

“…Androgens are important regulators of bone mass but the relative importance of testosterone (T) versus dihydrotestosterone (DHT) for the activation of the…”
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Liver-Derived Insulin-Like Growth Factor I (IGF-I) Is the Principal Source of IGF-I in Blood but Is Not Required for Postnatal Body Growth in Mice by Sjögren, Klara, Liu, Jun-Li, Blad, Kristina, Skrtic, Stanko, Vidal, Olle, Wallenius, Ville, LeRoith, Derek, Törnell, Jan, Olle G. P. Isaksson, Jansson, John-Olov, Ohlsson, Claes

“…The body growth of animals is regulated by growth hormone and IGF-I. The classical theory of this regulation is that most IGF-I in the blood originates in the…”
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