Search Results - "Sjöblom, M"

Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations by Dahlgren, D., Sjöblom, M., Lennernäs, H.

“…[Display omitted] Pharmaceutical excipients in drug products are defined as pharmacologically inactive and are integral constituents of all types of oral…”
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Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport by Dahlgren, D., Roos, C., Lundqvist, A., Tannergren, C., Sjöblom, M., Sjögren, E., Lennernäs, H.

“…[Display omitted] The small intestine mucosal barrier is physiologically regulated by the luminal conditions, where intestinal factors, such as diet and…”
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The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs by Dahlgren, D., Roos, C., Johansson, P., Tannergren, C., Lundqvist, A., Langguth, P., Sjöblom, M., Sjögren, E., Lennernäs, H.

“…[Display omitted] Pharmaceutical excipients that may affect gastrointestinal (GI) drug absorption are called critical pharmaceutical excipients, or…”
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Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model by Dahlgren, D., Roos, C., Peters, K., Lundqvist, A., Tannergren, C., Sjögren, E., Sjöblom, M., Lennernäs, H.

“…[Display omitted] The rat single-pass intestinal perfusion (SPIP) model is commonly used to investigate gastrointestinal physiology and membrane drug…”
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Long-term outcomes of extracapsular tonsillectomy in the treatment of obstructive sleep apnoea in adults by Knubb, Jenny, Sjöblom, Henrik M, Ikonen, Ella, Suomela, Miika, Piitulainen, Jaakko M

“…Tonsillectomy is an effective treatment option for obstructive sleep apnoea in selected adult patients, but there has been a lack of long-term follow-up data…”
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Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer by Roos, C., Dahlgren, D., Sjögren, E., Sjöblom, M., Hedeland, M., Lennernäs, H.

“…[Display omitted] The number of highly lipophilic active pharmaceutical ingredients (APIs) in pharmaceutical development has been constantly increasing over…”
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The progression of doxorubicin-induced intestinal mucositis in rats by Kullenberg, F., Peters, K., Luna-Marco, C., Salomonsson, A., Kopsida, M., Degerstedt, O., Sjöblom, M., Hellström, P. M., Heindryckx, F., Dahlgren, D., Lennernäs, H.

“…Chemotherapy-induced intestinal mucositis is a severe side effect contributing to reduced quality of life and premature death in cancer patients. Despite a…”
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Time-dependent effects on small intestinal transport by absorption-modifying excipients by Dahlgren, D., Roos, C., Lundqvist, A., Tannergren, C., Sjöblom, M., Sjögren, E., Lennernäs, H.

“…[Display omitted] The relevance of the rat single-pass intestinal perfusion model for investigating in vivo time-dependent effects of absorption-modifying…”
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Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions by Roos, C., Dahlgren, D., Sjögren, E., Sjöblom, M., Hedeland, M., Lennernäs, H.

“…[Display omitted] Oral administration of drug products is the preferred administration route. In recent decades there has been an increase in drug candidates…”
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Intracapsular tonsillectomy in the treatment of recurrent and chronic tonsillitis in adults: a protocol of a prospective, single-blinded, randomised study with a 5-year follow-up (the FINITE trial) by Piitulainen, Jaakko Matias, Uusitalo, Tapani, Sjöblom, Henrik M, Ivaska, Lotta E, Jegoroff, Henri, Kauko, Tommi, Kokki, Hannu, Kytö, Eero, Mansikka, Iisa, Ylikoski, Jenni, Jero, Jussi

“…IntroductionThe standard surgical treatment for recurrent or chronic tonsillitis is extracapsular tonsillectomy. Recent studies show that intracapsular…”
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Long-term oral melatonin administration reduces ethanol-induced increases in duodenal mucosal permeability and motility in rats by Sommansson, A., Yamskova, O., Schiöth, H. B., Nylander, O., Sjöblom, M.

“…Aim Increased intestinal epithelial permeability is associated with intestinal inflammation and dysfunction. The aim of the present study was to investigate…”
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Treatment of sleep apnoea with tonsillectomy: a retrospective analysis using long-term follow-up data by Sjöblom, Henrik M., Nahkuri, Max, Suomela, Miika, Jero, Jussi, Piitulainen, Jaakko M.

“…Purpose This single-group, retrospective, pre-test–post-test study was performed to examine clinical outcomes in treating obstructive sleep apnoea (OSA) with…”
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The selective cyclooxygenase-2 inhibitor parecoxib markedly improves the ability of the duodenum to regulate luminal hypertonicity in anaesthetized rats by Sedin, J., Sjöblom, M., Nylander, O.

“…Aim: To examine whether the prevention of post‐operative duodenal ileus by treatment with parecoxib, a selective cyclooxygenase‐2 (COX‐2) inhibitor, affects…”
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Patient injuries from tonsil and adenoid surgery in Finland by Sjöblom, Henrik M., Timgren, Jaakko M., Piitulainen, Jaakko M., Jero, Jussi

“…Objectives The aims of this national register‐based study were to examine patient injury claims related to tonsil and adenoid surgery injuries and to compare…”
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Prevention of duodenal ileus reveals functional differences in the duodenal response to luminal hypertonicity in Sprague-Dawley and Dark Agouti rats by Sedin, J., Sjöblom, M., Nylander, O.

“…Aim The mechanism by which the duodenum adjusts the luminal osmolality remains unclear. The aim was to compare the duodenal osmoregulation in response to…”
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Duodenal epithelial sensing of luminal acid: role of carbonic anhydrases by Sjöblom, M.

“…Sensing the luminal contents is a prerequisite to activate appropriate gastrointestinal functions. A major task of the duodenal epithelium is to resist the…”
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Apelin stimulation of duodenal bicarbonate secretion: feeding-dependent and mediated via apelin-induced release of enteric cholecystokinin by Flemström, G., Mäkelä, K., Purhonen, A. K., Sjöblom, M., Jedstedt, G., Walkowiak, J., Herzig, K. H.

“…Aims:  Apelin peptides are the endogenous ligand of the G protein‐coupled receptor APJ. Proposed actions include involvement in control of cardiovascular…”
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Screening of lactic acid bacteria from fermented vegetables by carbohydrate profiling and PCR–ELISA by Tamminen, M., Joutsjoki, T., Sjöblom, M., Joutsen, M., Palva, A., Ryhänen, E.‐L., Joutsjoki, V.

“…Aims:  The aim of this study was to identify potential souring agents, isolated from fermented plant material, by API 50 CHL assay and a molecular method based…”
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Modulation of mucosal permeability by vasoactive intestinal peptide or lidocaine affects the adjustment of luminal hypotonicity in rat duodenum by Nylander, O., Sjöblom, M.

“…Aims:  To examine whether modulation of paracellular solute permeability affects the capability of the duodenum to adjust luminal osmolality. Methods: …”
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Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion by Sjöblom, M, Jedstedt, G, Flemström, G

“…Melatonin is released from intestinal enterochromaffin cells and from the pineal gland, but its role in gastrointestinal function is largely unknown. Our aim…”
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