Search Results - "Sixma, J J"

Stability and change in burnout: A 10-year follow-up study among primary care physicians by Schaufeli, Wilmar B., Maassen, Gerard H., Bakker, Arnold B., Sixma, Herman J.

“…The aim of the present study is (1) to investigate the impact of patient demands on primary care physicians’ burnout and (2) to examine the stability and…”
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Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and α-Granules by Heijnen, Harry F.G., Schiel, Anja E., Fijnheer, Rob, Geuze, Hans J., Sixma, Jan J.

“…Platelet activation leads to secretion of granule contents and to the formation of microvesicles by shedding of membranes from the cell surface. Recently, we…”
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The role of collagen in thrombosis and hemostasis by Farndale, R. W., Sixma, J. J., Barnes, M. J., De Groot, P. G.

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Assessing the potential for improvement of primary care in 34 countries: a cross-sectional survey by Schäfer, Willemijn L A, Boerma, Wienke G W, Murante, Anna M, Sixma, Herman J M, Schellevis, François G, Groenewegen, Peter P

“…To investigate patients' perceptions of improvement potential in primary care in 34 countries. We did a cross-sectional survey of 69 201 patients who had just…”
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Functional Self-Association of von Willebrand Factor during Platelet Adhesion under Flow by Savage, Brian, Sixma, Jan J., Ruggeri, Zaverio M.

“…We have used recombinant wild-type human von Willebrand factor (VWF) and deletion mutants lacking the A1 and A3 domains, as well as specific function-blocking…”
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Structures of Glycoprotein Ibα and Its Complex with von Willebrand Factor A1 Domain by Huizinga, Eric G., Tsuji, Shizuko, Roland A. P. Romijn, Schiphorst, Marion E., de Groot, Philip G., Sixma, Jan J., Gros, Piet

“…Transient interactions of platelet-receptor glycoprotein Ibα (GpIbα) and the plasma protein von Willebrand factor (VWF) reduce platelet velocity at sites of…”
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The origin of P-selectin as a circulating plasma protein by Fijnheer, R, Frijns, C J, Korteweg, J, Rommes, H, Peters, J H, Sixma, J J, Nieuwenhuis, H K

“…P-selectin is a 140 kD protein found in the alpha-granules of platelets and the Weibel-Palade bodies of endothelial cells. On cell activation it is expressed…”
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Patient demands, lack of reciprocity, and burnout: a five-year longitudinal study among general practitioners by Bakker, Arnold B., Schaufeli, Wilmar B., Sixma, Herman J., Bosveld, Willem, Van Dierendonck, Dirk

“…This study among a sample of 207 general practitioners (GPs) uses a five-year longitudinal design to test a process model of burnout. On the basis of social…”
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Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women by ROEST, M, VAN DER SCHOUW, Y. T, DE VALK, B, MARX, J. J. M, TEMPELMAN, M. J, DE GROOT, P. G, SIXMA, J. J, BANGA, J. D

“…Background-The genetic background of hereditary hemochromatosis (HH) is homozygosity for a cysteine-to-tyrosine transition at position 282 in the HFE gene…”
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Protein A is the von Willebrand factor binding protein on Staphylococcus aureus by HARTLEIB, Jörg, KÖHLER, Nicola, DICKINSON, Richard B, CHHATWAL, Gursharan S, SIXMA, Jan J, HARTFORD, Orla M, FOSTER, Timothy J, PETERS, Georg, KEHREL, Beate E, HERRMANN, Mathias

“…Endovascular infection is a highly critical complication of invasive Staphylococcus aureus disease. For colonization, staphylococci must first adhere to…”
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Mapping the Collagen-binding Site in the von Willebrand Factor-A3 Domain by Romijn, Roland A., Westein, Erik, Bouma, Barend, Schiphorst, Marion E., Sixma, Jan J., Lenting, Peter J., Huizinga, Eric G.

“…The multimeric glycoprotein von Willebrand factor (VWF) mediates platelet adhesion to collagen at sites of vascular damage. The binding site for collagen types…”
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Measuring Relatives' Perspectives on the Quality of Palliative Care: The Consumer Quality Index Palliative Care by Claessen, Susanne J.J., MD, Francke, Anneke L., RN, PhD, Sixma, Herman J., PhD, de Veer, Anke J.E., PhD, Deliens, Luc, PhD

“…Abstract Context A Consumer Quality Index (CQ-index) is a questionnaire assessing the actual care experiences and how important the recipient finds certain…”
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Excessive urinary albumin levels are associated with future cardiovascular mortality in postmenopausal women by ROEST, Mark, BANGA, Jan Dirk, JANSSEN, Wilbert M. T, GROBBEE, Diederick E, SIXMA, Jan J, DE JONG, Paul E, DE ZEEUW, Dick, VAN DER SCHOUW, Yvonne T

“…Microalbuminuria is an early predictor of cardiovascular morbidity and mortality, in both diabetic patients and hypertensive patients. Little is known about…”
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Thrombospondin‐1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb): an alternative/backup mechanism to von Willebrand factor by Jurk, Kerstin, Clemetson, Kenneth J., Groot, Philip G., Brodde, Martin F., Steiner, Michael, Savion, Naphtali, Varon, David, Sixma, Jan J., Van Aken, Hugo, Kehrel, Beate E.

“…ABSTRACT Acute thrombotic arterial occlusion is the leading cause of morbidity and mortality in the Western world. Von Willebrand factor is thought to be the…”
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Platelet associated fibrinogen and ICAM-2 induce firm adhesion of neutrophils under flow conditions by Kuijper, P H, Gallardo Tores, H I, Lammers, J W, Sixma, J J, Koenderman, L, Zwaginga, J J

“…Surface-bound platelets support selectin-mediated rolling and beta2-integrin-mediated firm adhesion of neutrophils (PMN) under flow conditions. We examined…”
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Multivesicular Bodies Are an Intermediate Stage in the Formation of Platelet α-Granules by Heijnen, Harry F.G., Debili, Najet, Vainchencker, William, Breton-Gorius, Janine, Geuze, Hans J., Sixma, Jan J.

“…We have used ultrathin cryosectioning and immunogold cytochemistry to study the position of α-granules in the endocytic and biosynthetic pathways in…”
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Nitric oxide functions as an inhibitor of platelet adhesion under flow conditions by de Graaf, J C, Banga, J D, Moncada, S, Palmer, R M, de Groot, P G, Sixma, J J

“…Nitric oxide (NO) has been identified as endothelium-derived relaxing factor (EDRF), which, in addition to its relaxant effects on vascular smooth muscle…”
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Identification of the Collagen-binding Site of the von Willebrand Factor A3-domain by Romijn, Roland A.P., Bouma, Barend, Wuyster, Winnifred, Gros, Piet, Kroon, Jan, Sixma, Jan J., Huizinga, Eric G.

“…Von Willebrand factor (vWF) is a multimeric glycoprotein that mediates platelet adhesion and thrombus formation at sites of vascular injury. vWF functions as a…”
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Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding by Huizinga, Eric G, Plas, R Martijn van der, Kroon, Jan, Sixma, Jan J, Gros, Piet

“…Background: Bleeding from a damaged blood vessel is stopped by the formation of a platelet plug. The multimeric plasma glycoprotein, von Willebrand factor…”
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Soluble adhesion molecules reflect endothelial cell activation in ischemic stroke and in carotid atherosclerosis by FRIJNS, C. J. M, KAPPELLE, L. J, VAN GIJN, J, NIEUWENHUIS, H. K, SIXMA, J. J, FIJNHEER, R

“…Activation of endothelial cells and platelets plays an important role in the development of atherosclerosis and thrombotic disorders. Soluble adhesion…”
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