Search Results - "Siwak, C T"

Effect of age and level of cognitive function on spontaneous and exploratory behaviors in the beagle dog by Siwak, C T, Tapp, P D, Milgram, N W

“…Cognitively characterized young and aged beagle dogs were administered six different spontaneous behavior tests, which provided measures of locomotion,…”
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Behavioral Activating Effects of Adrafinil in Aged Canines by Siwak, C.T, Gruet, P, Woehrlé, F, Schneider, M, Muggenburg, B.A, Murphey, H.L, Callahan, H, Milgram, N.W

“…Adrafinil, a vigilance enhancing pharmaceutical, was administered to aged dogs for 14 consecutive days at doses of 10, 20, 30, or 40 mg/kg using a crossover…”
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Oral Administration of Adrafinil Improves Discrimination Learning in Aged Beagle Dogs by Milgram, Norton W, Siwak, Christina T, Gruet, Philippe, Atkinson, Patricia, Woehrlé, Frédérique, Callahan, Heather

“…Aged beagle dogs were trained on either a size or intensity discrimination task 2 h following treatment with either 20 mg/kg of adrafinil or a placebo control…”
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Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging by Tapp, P Dwight, Siwak, Christina T, Estrada, Jimena, Head, Elizabeth, Muggenburg, Bruce A, Cotman, Carl W, Milgram, Norton W

“…Several studies converge on the idea that executive processes age earlier than other cognitive processes. As part of a larger effort to investigate age-related…”
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Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs by Milgram, Norton W., Head, Elizabeth, Zicker, Steven C., Ikeda-Douglas, Candace, Murphey, Heather, Muggenberg, Bruce A., Siwak, Christina T., Dwight Tapp, P., Lowry, Stephen R., Cotman, Carl W.

“…The effects of long-term treatment with both antioxidants and a program of behavioral enrichment were studied as part of a longitudinal investigation of…”
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Effects of age on measures of complex working memory span in the beagle dog (Canis familiaris) using two versions of a spatial list learning paradigm by Tapp, P Dwight, Siwak, Christina T, Estrada, Jimena, Holowachuk, Daniel, Milgram, Norton W

“…The present study used two versions of a spatial list learning (SLL) paradigm to examine the effects of increased cognitive load on visuospatial working memory…”
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Locomotor Activity Rhythms in Dogs Vary With Age and Cognitive Status by Siwak, Christina T, Tapp, P. Dwight, Zicker, Steven C, Murphey, Heather L, Muggenburg, Bruce A, Head, Elizabeth, Cotman, Carl W, Milgram, Norton W

“…Beagle dogs exhibited diurnal patterns of locomotor activity that varied as a function of age, cognitive status, and housing environment. Aged dogs housed in…”
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Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs by Siwak, Christina T., Tapp, P. Dwight, Head, Elizabeth, Zicker, Steven C., Murphey, Heather L., Muggenburg, Bruce A., Ikeda-Douglas, Candace J., Cotman, Carl W., Milgram, Norton W.

“…The present experiment was part of a 3-year longitudinal study examining the effects of age and antioxidant treatment on cognitive decline in beagles. Two…”
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Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks by Tapp, P.Dwight, Siwak, Christina T, Head, Elizabeth, Cotman, Carl W, Murphey, Heather, Muggenburg, Bruce A, Ikeda-Douglas, Candace, Milgram, Norton W

“…The present study examined the effects of age on concept learning in beagle dogs. In experiment one, subjects were tested on a series of 2-choice size…”
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Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs by Siwak, C T, Gruet, P, Woehrlé, F, Muggenburg, B A, Murphey, H L, Milgram, N W

“…To compare the efficacy of adrafinil, propentofylline, and nicergoline for enhancing behavior of aged dogs. 36 Beagles between 9 and 16 years old. Dogs were…”
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Adrafinil: Effects on behavior and cognition in aged canines by Siwak, Christina T., Callahan, Heather, Norton W, Milgram

“…1. 1. Adrafinil is a novel vigilance promoting agent developed in France by Louis Lafon Laboratories. 2. 2. Adrafinil causes increased locomotion without…”
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Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function by Siwak-Tapp, Christina T., Head, Elizabeth, Muggenburg, Bruce A., Milgram, Norton W., Cotman, Carl W.

“…New neurons are continually produced in the adult mammalian brain from progenitor cells located in specific brain regions, including the subgranular zone (SGZ)…”
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Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging by Tapp, P Dwight, Siwak, Christina T, Gao, Fu Qiang, Chiou, Jr-Yuan, Black, Sandra E, Head, Elizabeth, Muggenburg, Bruce A, Cotman, Carl W, Milgram, Norton W, Su, Min-Ying

“…Application of magnetic resonance imaging (MRI) techniques reveals that human brain aging varies across cortical regions. One area particularly sensitive to…”
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Adrafinil: Effects on behavior and cognition in aged canines: Canine cognition, aging and neuropathology by SIWAK, C. T, CALLAHAN, H, MILGRAM, N. W

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Age-dependent decline in locomotor activity in dogs is environment specific by Siwak, Christina T., Murphey, Heather L., Muggenburg, Bruce A., Milgram, Norton W.

“…A decrease in motor activity is an expected concomitant of normal aging and has been reported in humans and nonhuman mammals. We have previously failed to find…”
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Adrafinil disrupts performance on a delayed nonmatching-to-position task in aged beagle dogs by Siwak, Christina T, Tapp, P.Dwight, Milgram, Norton W

“…Previous studies in humans and dogs have reported beneficial effects of adrafinil on specific cognitive functions. The effects in dogs are limited to a single…”
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